(data stored in ACNUC8465 zone)

SWISSPROT: B0W7R1_CULQU

ID   B0W7R1_CULQU            Unreviewed;       339 AA.
AC   B0W7R1;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   11-DEC-2019, entry version 68.
DE   SubName: Full=Dual specificity mitogen-activated protein kinase kinase 3 {ECO:0000313|EMBL:EDS38205.1, ECO:0000313|VectorBase:CPIJ003157-PA};
GN   Name=6034427 {ECO:0000313|VectorBase:CPIJ003157-PA};
GN   ORFNames=CpipJ_CPIJ003157 {ECO:0000313|EMBL:EDS38205.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Holometabola; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176 {ECO:0000313|Proteomes:UP000002320};
RN   [1] {ECO:0000313|Proteomes:UP000002320, ECO:0000313|VectorBase:CPIJ003157-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|Proteomes:UP000002320,
RC   ECO:0000313|VectorBase:CPIJ003157-PA};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EDS38205.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS38205.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|VectorBase:CPIJ003157-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|VectorBase:CPIJ003157-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC       {ECO:0000256|RuleBase:RU000304}.
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DR   EMBL; DS231855; EDS38205.1; -; Genomic_DNA.
DR   RefSeq; XP_001844745.1; XM_001844693.1.
DR   STRING; 7176.CPIJ003157-PA; -.
DR   EnsemblMetazoa; CPIJ003157-RA; CPIJ003157-PA; CPIJ003157.
DR   GeneID; 6034427; -.
DR   KEGG; cqu:CpipJ_CPIJ003157; -.
DR   VectorBase; CPIJ003157-RA; CPIJ003157-PA; CPIJ003157.
DR   eggNOG; KOG0984; Eukaryota.
DR   eggNOG; ENOG410XT3F; LUCA.
DR   HOGENOM; HOG000234206; -.
DR   InParanoid; B0W7R1; -.
DR   KO; K04432; -.
DR   OMA; WGTPFEQ; -.
DR   OrthoDB; 688282at2759; -.
DR   PhylomeDB; B0W7R1; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
DR   PRODOM; B0W7R1.
DR   SWISS-2DPAGE; B0W7R1.
KW   ATP-binding {ECO:0000256|RuleBase:RU000304};
KW   Kinase {ECO:0000313|EMBL:EDS38205.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000304};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
KW   Transferase {ECO:0000313|EMBL:EDS38205.1}.
FT   DOMAIN          49..310
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..27
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   339 AA;  38091 MW;  20CA8227065C9ADD CRC64;
     MSRRPKGPGL KINVTEATNS TPMTPPRNLD KTATITIGSN TFVVEADNLE KICDLGRGAY
     GIVEKMRHKQ TNTIMAVKRI TATGQTQEQK RLLMDLDISM RASDCQYTVH FYGALFREGD
     VWICMEVMDT SIDKFYPIVF KNGRKMPEDI LGKIAVAVVN ALNYLYTKLR VIHRDVKPSN
     ILINRQGDVK ICDFGISGYL VDSVAKTIDA GCKPYMAPER IDPQGNPGEY NIKSDVWSLG
     ISLIEMATGN FPYSTWGSPF EQLKQVVKDD PPRLRSDDFG DVFKNLIIAC LQKNFQNRYN
     YEQLLNHPFI QEHTEKTTDV ATFVSEILDL AAGPPPPTN
//

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