(data stored in SCRATCH zone)

SWISSPROT: B1K387_BURCC

ID   B1K387_BURCC            Unreviewed;       433 AA.
AC   B1K387;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   08-MAY-2019, entry version 82.
DE   RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003370};
GN   OrderedLocusNames=Bcenmc03_3589 {ECO:0000313|EMBL:ACA92741.1};
OS   Burkholderia cenocepacia (strain MC0-3).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=406425 {ECO:0000313|EMBL:ACA92741.1, ECO:0000313|Proteomes:UP000002169};
RN   [1] {ECO:0000313|Proteomes:UP000002169}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC0-3 {ECO:0000313|Proteomes:UP000002169};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 2 of Burkholderia cenocepacia MC0-
RT   3.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16;
CC         Evidence={ECO:0000256|RuleBase:RU003370};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       isocitrate from oxaloacetate: step 1/2.
CC       {ECO:0000256|RuleBase:RU003370}.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003406}.
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DR   EMBL; CP000959; ACA92741.1; -; Genomic_DNA.
DR   RefSeq; WP_011355741.1; NC_010515.1.
DR   EnsemblBacteria; ACA92741; ACA92741; Bcenmc03_3589.
DR   KEGG; bcm:Bcenmc03_3589; -.
DR   HOGENOM; HOG000021224; -.
DR   KO; K01647; -.
DR   OMA; TVGWCAQ; -.
DR   BioCyc; BCEN406425:G1GBC-3811-MONOMER; -.
DR   UniPathway; UPA00223; UER00717.
DR   Proteomes; UP000002169; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.230.10; -; 1.
DR   Gene3D; 1.10.580.10; -; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   InterPro; IPR010953; Citrate_synthase_typ-I.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; SSF48256; 1.
DR   TIGRFAMs; TIGR01798; cit_synth_I; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1K387.
DR   SWISS-2DPAGE; B1K387.
KW   Acyltransferase {ECO:0000313|EMBL:ACA92741.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002169};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001369,
KW   ECO:0000256|RuleBase:RU003370, ECO:0000313|EMBL:ACA92741.1};
KW   Tricarboxylic acid cycle {ECO:0000256|RuleBase:RU003370}.
FT   ACT_SITE    310    310       {ECO:0000256|PIRSR:PIRSR001369-1}.
FT   ACT_SITE    368    368       {ECO:0000256|PIRSR:PIRSR001369-1}.
SQ   SEQUENCE   433 AA;  48411 MW;  6717D029E3D57CD8 CRC64;
     MTPSDVKATL SFSDNSPSVE LPIYKGTMGP DVIDIRKLYG QTGKFTYDPG FMSTAACNSA
     ITYIDGDKGE LLYRGYPIDN LAQNADFLES CYLLLKGELP NAAQKKEFVD TVTKHTMVHE
     QMHFFFRGFR RDAHPMAILV AAVGALSAFY HDSLDINDPR HREVSAIRMI AKLPTLVAMA
     YKYSIGQPFV YPKNSLSYSA NFMHMMFSNP CEEYKVNDVL VRALDRILIL HADHEQNAST
     STVRLAGSSG ANPFACIAAG IACLWGPAHG GANEAALNML EQIGSPDNIP EFIKQVKDKN
     SGVKLMGFGH RVYKNYDPRA KLMRETCYEV LNELGLHDDP LFKLAMQLEK IALEDEYFVS
     RKLYPNVDFY SGIVQRALGI PTSMFTCIFA MARTVGWIAQ WNEMIGDPEQ KIGRPRQLFI
     GDTPREAKPL NAR
//

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