(data stored in SCRATCH zone)

SWISSPROT: B1K4D7_BURCC

ID   B1K4D7_BURCC            Unreviewed;       470 AA.
AC   B1K4D7;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   08-MAY-2019, entry version 59.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   OrderedLocusNames=Bcenmc03_3703 {ECO:0000313|EMBL:ACA92855.1};
OS   Burkholderia cenocepacia (strain MC0-3).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=406425 {ECO:0000313|EMBL:ACA92855.1, ECO:0000313|Proteomes:UP000002169};
RN   [1] {ECO:0000313|Proteomes:UP000002169}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC0-3 {ECO:0000313|Proteomes:UP000002169};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 2 of Burkholderia cenocepacia MC0-
RT   3.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; CP000959; ACA92855.1; -; Genomic_DNA.
DR   RefSeq; WP_006479486.1; NC_010515.1.
DR   EnsemblBacteria; ACA92855; ACA92855; Bcenmc03_3703.
DR   KEGG; bcm:Bcenmc03_3703; -.
DR   HOGENOM; HOG000153773; -.
DR   KO; K00012; -.
DR   OMA; LCTEWDE; -.
DR   BioCyc; BCEN406425:G1GBC-3931-MONOMER; -.
DR   Proteomes; UP000002169; Chromosome 2.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1K4D7.
DR   SWISS-2DPAGE; B1K4D7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002169};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124,
KW   ECO:0000313|EMBL:ACA92855.1}.
FT   DOMAIN      324    436       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    270    270       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      86     86       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     121    121       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     158    158       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     273    273       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     338    338       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   470 AA;  51228 MW;  A79249123E5E4DEA CRC64;
     MNLTIIGSGY VGLVTGACLA DIGHDVFCLD VDQAKIDILN NGGVPIHEPG LKEVIARNRS
     AGRLRFSTDI EAAVAHGDVQ FIAVGTPPDE DGSADLQYVL AAARNIGRYM TGFKVIVDKS
     TVPVGTAERV RAAVAEELAK RGGDQMFSVV SNPEFLKEGA AVDDFTRPDR IVIGCDDDVP
     GERARELMKK LYAPFNRNHE RTLYMDVRSA EFTKYAANAM LATRISFMNE LANLADRFGA
     DIEAVRRGIG SDPRIGYHFL YAGCGYGGSC FPKDVEALIR TADEHGQSLQ ILKAVSSVNA
     TQKRVLAEKI VARFGEDLSG RTFALWGLAF KPNTDDMREA PSRELIAELL SRGARVAAYD
     PVAQQEARRV IALDLADHPS WLERLSFVDD EAQAARDADA LVIVTEWKAF KSPDFVALGR
     LWKTPVIFDG RNLYEPETMS EQGIEYHPIG RPGSRQAVAA RVPGAARASA
//

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