(data stored in SCRATCH zone)

SWISSPROT: B1K4W9_BURCC

ID   B1K4W9_BURCC            Unreviewed;       546 AA.
AC   B1K4W9;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   08-MAY-2019, entry version 59.
DE   SubName: Full=Thiamine pyrophosphate protein domain protein TPP-binding {ECO:0000313|EMBL:ACA92893.1};
GN   OrderedLocusNames=Bcenmc03_3741 {ECO:0000313|EMBL:ACA92893.1};
OS   Burkholderia cenocepacia (strain MC0-3).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=406425 {ECO:0000313|EMBL:ACA92893.1, ECO:0000313|Proteomes:UP000002169};
RN   [1] {ECO:0000313|Proteomes:UP000002169}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC0-3 {ECO:0000313|Proteomes:UP000002169};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 2 of Burkholderia cenocepacia MC0-
RT   3.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; CP000959; ACA92893.1; -; Genomic_DNA.
DR   RefSeq; WP_011548230.1; NC_010515.1.
DR   EnsemblBacteria; ACA92893; ACA92893; Bcenmc03_3741.
DR   KEGG; bcm:Bcenmc03_3741; -.
DR   HOGENOM; HOG000258447; -.
DR   KO; K01652; -.
DR   OMA; IRWKQAV; -.
DR   BioCyc; BCEN406425:G1GBC-3972-MONOMER; -.
DR   Proteomes; UP000002169; Chromosome 2.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1K4W9.
DR   SWISS-2DPAGE; B1K4W9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002169};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN        1    167       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      186    318       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      378    524       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
SQ   SEQUENCE   546 AA;  60815 MW;  619E456E7F7AAFDA CRC64;
     MKASDLFVKA LEAEGVEYVF GIPGEENLDL LESLRRSKIK LVLTRHEQAA GFMAATYGRL
     TGRTGVCLAT LGPGATNFVT AAAYAQLGGM PMLMITGQKP IKSSKQGHFQ IVDVVDMMQP
     LTKFTRQIVS IGNIPSAVRE AFRRAEEERP GAAHLELPED IAHEEGDGKP IPRSYSRRPV
     AEEKAVAHAV DAIQAARHPL LMIGAGGNRK TTCKMLLEFV DKTGIPFFTT QMGKGVIDET
     HPLWLGNATL SDGDFVHRAI EQADCIINVG HDVIEKPPFF MRTDDKTVIH VNFLGAQVDP
     VYFPQIEVVG DIANAVWQMK EALTPQSHWD FERFKMIKAH FDAHLEKGQH DPRFPMYPVR
     IVNDLYNALP VDGIVCLDNG MYKIWFARYW RAHEPNSLLL DNALASMGAG LPSAIATKIV
     HPQRKVIAVC GDGGFMMNSQ ELETAVRLKL DIVVMILRDD AFGMIRWKQE NMNFPDFAMT
     LQNPDFVSYA QSYGAHGHRV ESADDLEPLL RECFSSPGVH VIDVPIDYSD NERVLNREIK
     RLSAQL
//

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