(data stored in SCRATCH zone)

SWISSPROT: B1VKL3_STRGG

ID   B1VKL3_STRGG            Unreviewed;       489 AA.
AC   B1VKL3;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   07-JUN-2017, entry version 65.
DE   RecName: Full=DNA helicase {ECO:0000256|SAAS:SAAS00745194};
DE            EC=3.6.4.12 {ECO:0000256|SAAS:SAAS00745194};
GN   OrderedLocusNames=SGR_15t {ECO:0000313|EMBL:BAG16844.1}, SGR_7124t
GN   {ECO:0000313|EMBL:BAG23951.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG16844.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG16844.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685}, and
RC   NBRC 13350 {ECO:0000313|EMBL:BAG16844.1};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
RN   [2] {ECO:0000313|EMBL:BAG16844.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NBRC 13350 {ECO:0000313|EMBL:BAG16844.1};
RX   PubMed=18364359; DOI=10.1074/jbc.M710461200;
RA   Funabashi M., Funa N., Horinouchi S.;
RT   "Phenolic lipids synthesized by type III polyketide synthase confer
RT   penicillin resistance on Streptomyces griseus.";
RL   J. Biol. Chem. 283:13983-13991(2008).
RN   [3] {ECO:0000313|EMBL:BAG16844.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NBRC 13350 {ECO:0000313|EMBL:BAG16844.1};
RA   Hirano S., Tanaka K., Ohnishi Y., Horinouchi S.;
RT   "Conditionally positive effect of the TetR-family transcriptional
RT   regulator AtrA on streptomycin production by Streptomyces griseus.";
RL   Microbiology (Mosc.) 154:905-914(2008).
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC       {ECO:0000256|SAAS:SAAS00745240}.
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|SAAS:SAAS00597767}.
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DR   EMBL; AP009493; BAG16844.1; -; Genomic_DNA.
DR   EMBL; AP009493; BAG23951.1; -; Genomic_DNA.
DR   RefSeq; WP_012377431.1; NC_010572.1.
DR   ProteinModelPortal; B1VKL3; -.
DR   STRING; 455632.SGR_7124t; -.
DR   EnsemblBacteria; BAG16844; BAG16844; SGR_15t.
DR   EnsemblBacteria; BAG23951; BAG23951; SGR_7124t.
DR   GeneID; 6213241; -.
DR   KEGG; sgr:SGR_15t; -.
DR   KEGG; sgr:SGR_7124t; -.
DR   PATRIC; fig|455632.4.peg.14; -.
DR   eggNOG; ENOG4106SE9; Bacteria.
DR   eggNOG; COG0210; LUCA.
DR   HOGENOM; HOG000040837; -.
DR   OMA; ITHDFYL; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1VKL3.
DR   SWISS-2DPAGE; B1VKL3.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00745276};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00627189};
KW   Helicase {ECO:0000256|SAAS:SAAS00493105, ECO:0000313|EMBL:BAG16844.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00745169};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00745105};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001685}.
FT   DOMAIN        4    279       UvrD-like helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51198}.
SQ   SEQUENCE   489 AA;  53587 MW;  852C4C37222909B5 CRC64;
     MPAPTDEQTA AADRFHAGDH LALQAGAGTG KTSTLALLAH STRRRGRYIA YNKAIAQEAA
     TRFPSTVTCK TAHALAYAAV GHRYRTRLNS PRQPSWKTGH HLGITKTLRI GDRDLSPRAL
     SYATLRTLTR FCHSADPALT DHHVPRLRNL EDAGHHRELT ALVMPFARTA WADLQNPDAG
     AVRFDHDHYL KIWALTEPAI PADFFLLDEA QDTNPVVEQV FNAQRNHAQL VMVGDSAQAI
     YQWRGARDVM TAFRGTGLTL SRSFRFGPDL AAEANRWLSI ATAPLRLAGT DTIPTTLGPV
     DQPDAILCRT NVGAMREVMQ LLDTGHRVAL TGGGESLQAL TRAADDLRAG RRTFHPELLL
     FSTWGDLQDY AANDPAGRDL QPLVDLVDTH GTEAILNAVH RLDPESTADV TVSTAHKSKG
     REWASVKIAD DFTPPRDTDK KDDHGRPIPG RVDEAEARLA YVAVTRARHR LDLGGLSWIN
     DHPDGTPPA
//

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