(data stored in SCRATCH zone)

SWISSPROT: B1VNQ2_STRGG

ID   B1VNQ2_STRGG            Unreviewed;       508 AA.
AC   B1VNQ2;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   08-MAY-2019, entry version 78.
DE   SubName: Full=Putative two-component system sensor kinase {ECO:0000313|EMBL:BAG17075.1};
GN   OrderedLocusNames=SGR_246 {ECO:0000313|EMBL:BAG17075.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17075.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17075.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; AP009493; BAG17075.1; -; Genomic_DNA.
DR   RefSeq; WP_012377645.1; NC_010572.1.
DR   STRING; 455632.SGR_246; -.
DR   EnsemblBacteria; BAG17075; BAG17075; SGR_246.
DR   GeneID; 6211487; -.
DR   KEGG; sgr:SGR_246; -.
DR   PATRIC; fig|455632.4.peg.225; -.
DR   eggNOG; ENOG41065SU; Bacteria.
DR   eggNOG; COG0642; LUCA.
DR   HOGENOM; HOG000223177; -.
DR   KO; K07654; -.
DR   OMA; MAADLIF; -.
DR   OrthoDB; 1827824at2; -.
DR   BioCyc; SGRI455632:G1G2X-243-MONOMER; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; B1VNQ2.
DR   SWISS-2DPAGE; B1VNQ2.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:BAG17075.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     16     36       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      201    253       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      268    477       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   508 AA;  53819 MW;  C2DB06140018C372 CRC64;
     MKIPGASAAF GVRTRLVLAF LLVAAVSAVT TAALTYREAR SAVLERAQDT AVASFREEVE
     RFVPGLPLDL EAVRWELYDI AARSKPHPWI VFAEYGSTRV SSGDRPVSGV LTEDLRRAAR
     TAPHGSFQRV VKDGKAYLTI GMPVMTRVVA GGGAVPSGLI LFAVMPMTNE ETDIDALVTA
     ARDGALPGLA VALVPALFAA RSVLRPVREL RRAADSMGGG RLDARIAVRG RDEMADLART
     FNSSAARLEH SVQELRDAGA RARRFASDVS HELRTPLAGM LAVTDVLDEE AATLDPDTAR
     AVRLISAETG KLAVLVEDLM EMSRFDARAA ELTTDEVDAA EAVRRSLSGR KWQDRVRAEL
     PEGIRIRLDP RRFDVIVANL VGNALHHGAE PVTVRLSSRA GSLITEVRDS GPGIAPDALP
     HVFDRFYKAD AARSRSSGSG LGLAITQENV RLHGGTIRAQ NAPGGGALFT VELPFDGPAS
     GHGAPDGPAT AHGEGPGTGP HTSTEAGA
//

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