(data stored in SCRATCH zone)

SWISSPROT: B1VNQ5_STRGG

ID   B1VNQ5_STRGG            Unreviewed;       272 AA.
AC   B1VNQ5;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   07-JUN-2017, entry version 53.
DE   SubName: Full=Streptomycin 6-phosphotransferase {ECO:0000313|EMBL:BAG17078.1};
GN   Name=aphE {ECO:0000313|EMBL:BAG17078.1};
GN   OrderedLocusNames=SGR_249 {ECO:0000313|EMBL:BAG17078.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17078.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17078.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase
CC       family. {ECO:0000256|PIRNR:PIRNR000706}.
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DR   EMBL; AP009493; BAG17078.1; -; Genomic_DNA.
DR   RefSeq; WP_012377648.1; NG_047411.1.
DR   ProteinModelPortal; B1VNQ5; -.
DR   STRING; 455632.SGR_249; -.
DR   EnsemblBacteria; BAG17078; BAG17078; SGR_249.
DR   GeneID; 6212328; -.
DR   KEGG; sgr:SGR_249; -.
DR   PATRIC; fig|455632.4.peg.229; -.
DR   eggNOG; ENOG4108R0M; Bacteria.
DR   eggNOG; COG3231; LUCA.
DR   HOGENOM; HOG000233068; -.
DR   KO; K10673; -.
DR   OMA; ADTVVCH; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd05150; APH; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR024165; Kan/Strep_kinase.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   Pfam; PF01636; APH; 1.
DR   PIRSF; PIRSF000706; Kanamycin_kin; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1VNQ5.
DR   SWISS-2DPAGE; B1VNQ5.
KW   Antibiotic resistance {ECO:0000256|PIRNR:PIRNR000706};
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR000706};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Kinase {ECO:0000256|PIRNR:PIRNR000706};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000706};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001685};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000706,
KW   ECO:0000313|EMBL:BAG17078.1}.
FT   DOMAIN       24    263       APH. {ECO:0000259|Pfam:PF01636}.
FT   ACT_SITE    190    190       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000706-1}.
SQ   SEQUENCE   272 AA;  29032 MW;  1F3197786B7B9700 CRC64;
     MSDHPGPGAV TPELFGVGGD WLAVTAGESG ASVFRAADAT RYAKCVPAAD AAGLEAERDR
     IAWLSGQGVP GPRVLDWYAG DAGACLVTRA VPGVPADRVG ADDLRTAWGA VADAVRRLHE
     VPVASCPFRR GLDSVVDAAR DVVARGAVHP EFLPVEQRLA PPAELLARLT GELARRRDQE
     AADTVVCHGD LCLPNIVLHP ETLEVSGFID LGRLGAADRH ADLALLLANA RETWVDEERA
     RFADAAFAER YGIAPDPERL RFYLHLDPLT WG
//

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