(data stored in SCRATCH zone)

SWISSPROT: B1VQ44_STRGG

ID   B1VQ44_STRGG            Unreviewed;       602 AA.
AC   B1VQ44;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   05-JUL-2017, entry version 67.
DE   RecName: Full=Cytochrome c oxidase subunit 1 {ECO:0000256|RuleBase:RU363061};
DE            EC=1.9.3.1 {ECO:0000256|RuleBase:RU363061};
GN   OrderedLocusNames=SGR_316 {ECO:0000313|EMBL:BAG17145.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17145.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17145.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. CO I is the
CC       catalytic subunit of the enzyme. Electrons originating in
CC       cytochrome c are transferred via the copper A center of subunit 2
CC       and heme A of subunit 1 to the bimetallic center formed by heme A3
CC       and copper B. {ECO:0000256|RuleBase:RU363061}.
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O. {ECO:0000256|RuleBase:RU363061}.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC       {ECO:0000256|RuleBase:RU363061}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU363061}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU363061}.
CC   -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
CC       {ECO:0000256|RuleBase:RU363061}.
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DR   EMBL; AP009493; BAG17145.1; -; Genomic_DNA.
DR   ProteinModelPortal; B1VQ44; -.
DR   STRING; 455632.SGR_316; -.
DR   EnsemblBacteria; BAG17145; BAG17145; SGR_316.
DR   KEGG; sgr:SGR_316; -.
DR   eggNOG; ENOG4105BZ9; Bacteria.
DR   eggNOG; COG0843; LUCA.
DR   HOGENOM; HOG000085274; -.
DR   KO; K02274; -.
DR   OMA; QMITFTE; -.
DR   UniPathway; UPA00705; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.210.10; -; 1.
DR   InterPro; IPR023616; Cyt_c_oxase-like_su1_dom.
DR   InterPro; IPR000883; Cyt_C_Oxase_1.
DR   InterPro; IPR023615; Cyt_c_Oxase_su1_BS.
DR   InterPro; IPR014241; Cyt_c_oxidase_su1_bac.
DR   PANTHER; PTHR10422; PTHR10422; 1.
DR   Pfam; PF00115; COX1; 1.
DR   PRINTS; PR01165; CYCOXIDASEI.
DR   SUPFAM; SSF81442; SSF81442; 1.
DR   TIGRFAMs; TIGR02891; CtaD_CoxA; 1.
DR   PROSITE; PS50855; COX1; 1.
DR   PROSITE; PS00077; COX1_CUB; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1VQ44.
DR   SWISS-2DPAGE; B1VQ44.
KW   Cell membrane {ECO:0000256|RuleBase:RU363061};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Copper {ECO:0000256|RuleBase:RU363061};
KW   Electron transport {ECO:0000256|RuleBase:RU363061};
KW   Heme {ECO:0000256|RuleBase:RU363061};
KW   Iron {ECO:0000256|RuleBase:RU363061};
KW   Membrane {ECO:0000256|RuleBase:RU363061};
KW   Metal-binding {ECO:0000256|RuleBase:RU363061};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU363061};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001685};
KW   Respiratory chain {ECO:0000256|RuleBase:RU363061};
KW   Transmembrane {ECO:0000256|RuleBase:RU363061};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363061};
KW   Transport {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM     69     91       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    111    132       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    153    171       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    200    225       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    237    263       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    283    307       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    319    340       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    346    368       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    389    409       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    421    447       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    459    481       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    501    525       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   DOMAIN       60    566       COX1. {ECO:0000259|PROSITE:PS50855}.
SQ   SEQUENCE   602 AA;  66950 MW;  5C781878F507C9B6 CRC64;
     MSHRTDLRGS ILVAESTRAV DRRSVVVTTR GISQSVETDT ADQDEMPVRR GEPGNVVVKW
     MTTTDHKTIG TLYLVTSFAF FCVGGLMALV MRAELARPGI QLISNEQFNQ AFTMHGTIML
     LMFATPLFAG FANWIMPLQI GAPDVAFPRL NMFAYWLYLF GSLIAVAGFL TPQGAADFGW
     FAYSPLNDAV RSPGIGADMW IMGLAFSGFG TILGSVNFIT TIICMRAPGM TMFRMPIFVW
     NVLLTGVLVL LAFPVLAAAL LALEADRKFG AHVFDAANGG ALLWQHLFWF FGHPEVYIIA
     LPFFGIVTEI LPVFSRKPVF GYIGLVAATI AIAGLSATVW AHHMFVTGGV LLPFFSFMTF
     LIAVPTGVKF FNWIGTMWKG SLSLETPMLW SVGFLVTFLF GGLTGIILAS PPLDFHVSDS
     YFVVAHFHYV VFGTVVFAMF AGFHFWWPKF TGKMLDERLG KMTFWTLFVG FHGTFLVQHW
     LGAEGMPRRY ADYLEADGFT ALNTISTISS FLLGLSILPF FYNIWKTAKY GRKIEVDDPW
     GYGRSLEWAT SCPPPRHNFV TLPRIRSESP AFDLHHPDVR SLEQVTNRPQ NSTIVAPGDQ
     HE
//

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