(data stored in SCRATCH zone)

SWISSPROT: B1VQH7_STRGG

ID   B1VQH7_STRGG            Unreviewed;      5193 AA.
AC   B1VQH7;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   30-AUG-2017, entry version 63.
DE   SubName: Full=Putative NRPS {ECO:0000313|EMBL:BAG17278.1};
GN   OrderedLocusNames=SGR_449 {ECO:0000313|EMBL:BAG17278.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17278.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17278.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00258}.
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DR   EMBL; AP009493; BAG17278.1; -; Genomic_DNA.
DR   RefSeq; WP_012377803.1; NC_010572.1.
DR   ProteinModelPortal; B1VQH7; -.
DR   STRING; 455632.SGR_449; -.
DR   EnsemblBacteria; BAG17278; BAG17278; SGR_449.
DR   GeneID; 6211823; -.
DR   KEGG; sgr:SGR_449; -.
DR   PATRIC; fig|455632.4.peg.426; -.
DR   eggNOG; COG1020; LUCA.
DR   HOGENOM; HOG000229991; -.
DR   OMA; RELSACY; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 4.
DR   Pfam; PF13193; AMP-binding_C; 4.
DR   Pfam; PF00668; Condensation; 6.
DR   Pfam; PF00550; PP-binding; 4.
DR   SMART; SM00823; PKS_PP; 4.
DR   SUPFAM; SSF47336; SSF47336; 4.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 4.
DR   TIGRFAMs; TIGR01720; NRPS-para261; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 4.
DR   PROSITE; PS00455; AMP_BINDING; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
DR   PRODOM; B1VQH7.
DR   SWISS-2DPAGE; B1VQH7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001685}.
FT   DOMAIN     1006   1073       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     2065   2132       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     3572   3639       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     4636   4702       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   MOD_RES    2098   2098       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
FT   MOD_RES    3604   3604       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
SQ   SEQUENCE   5193 AA;  550177 MW;  DD829E2B2EAA3787 CRC64;
     MSADHGLEDI LPLAPLQEGL LFHADLSHAP GGPGATGGLD VYTMRLVFRL DGDLDTTALR
     RAADTVLDRH PHLRAAFLQE GLDRPVQAIP RTAEVPWRAI DLRDAHPDRQ RAEEQRILDE
     ERAHRFDLTR PPLLRLTLLR HGDQDHTLVL TAHHILLDGW SVPLLGKELF TAYAQHAKAP
     AAPALPAVRP YRDFLAWLAA QDRPAAESAW REALAPLAAP TLLAPATAGA AVPEPPVQLD
     LRLSAATGEA LGAFAAARQL TTATAHQAAW GITLARLTGR ADVAFGTTVS GRPADLDGAE
     SMIGLFINTL PVVVHAPARA PLADVAAALQ ADRAKLLGHE HLGLPDLQRL AGTGELFDTL
     LVVENFGVDT RGLADAQAAG GLTVRSVRGE DATHYPVTVV VHPGPETRIA LRYRPDLVTA
     DRARALGTAY VRILEALAAT PTAPVGAVGL LTAQDRRRVL DDGEAALAPG TEERTGTLPD
     RFARAVALEP DATAVTDGDR ALSYRELDAL SDRVAHLLSA HGAGPGTCVA LSLEPSAEQI
     GAILGVLKTG AAYLPLPADA PADRIRPQLA SARPATGLTA SARRRDGLPA TDGSADRPGA
     GWLTLDDLPP ADPGVTPYTV PGISPADAAY VIHTSGSTGR PKGVVVEHRN VLRLLDATDD
     DFGFGRDDVW TLFHSYAFDF SVWEIFGALL YGGRLVVVDH ATTRAPEEFA ALLRREHVTV
     LNQTPSAFHQ LADVLLGREA GNGGELALRT VVFGGEALDP GRLAGWFERY GDDGPELVNM
     YGITETTVHV THRTLEAADT DATAVPTSPV GRPLDDLGVR LLDAALHPVA PGATGELYVA
     GPGLARGYLG RHALTATRFV ADPYGPPGTR MYRTGDLARW TADGELDHLG RADEQVQIRG
     FRVEPGEARA ALAALDEVAD AVVLARPAPG GGTRLLAYAT PAAGPLAPER LRRALRERLP
     DYLVPAAVIP VDHWPLTVNG KLDRNALPEP EAAAATPGGR APATPQEEIV AHLFADILER
     ERVAADDDFF ALGGHSLLAT RLASRIRAAL DVSLSVRDVF EAATVAALAR RVQHAGRAPE
     PLRPRPRPAD LPLSPAQTRL WFLQQLHGVG ADYNIPFAAR LTGPLDLPAL RAAVTDVMTR
     HESLRTVFPA TDGRPRQHVV EESDLPAPLT VTDATGADGE LRRYIEETAA TPFDVERDVP
     LRAGLLRLAP DQHLIVLVVH HIAADQWSAR PLLTDLATAY AARTGGAAPA WPPLPVQYAD
     FTLWQREALG WDDDAPAADG PAAAQLDHWR TTLSDLPAEL PLPTDRPRPP VPSHRGGFVR
     FTVPPGVHTA MRALARTEST SLFMVAHAAL AALLARTGSG RDIVIGTPVA GRHDTALDDL
     VGFFVNNLVL RTDLSGDPSF RDLLRRVREA DLAAYAHADI PFEHLVDALA PHRSLARHPI
     FQVMLAYENR RTGEIGLPGL TTTTVPAYGR SAKFDLTFTL AERDGADGIE GVLEYAEDLF
     EPATARALAD RLVRLLTEAV TAPATLLHRL EVLGPAERAE LLGRPDGLGA PHGDSSTTLP
     GLFDAVAAAH PDAPAVAGPD LATGDRTELD YRGLDTAANA LAHDLIAHGV RPQDRVAVML
     PRTVEAVVAL LAVAKTGAVY LPVDPDYPAE RIAHMLTDAA PTLVLTTPGT PASDGVPRLE
     TDGALRTRSA DDPGLWRTQR PDAAAYIIYT SGSTGRPKGV AVTHTGLPAL ARTLADAFGA
     GQGDRVLQFA SLSFDTSVWE IVMALFSGAA LEIVPADRRL GEPLAAFLAE HRVTHLTVPP
     AVLAALPEDA VAPGTTLIVA GEACTPALVR AWAGRTRMFN SYGPTETTVD ATLWRCDPDR
     LRADDNSPVP VGAAVAETAA LVLDAALRPV PPGTPGELYV AGSGLARGYL GRPGLTATRF
     VADPYGAPGT RMYRTGDLAR RRFDGELEYL GRADHQVKLR GFRIELGEIE SALTALPGVR
     QAAAVLREDR PGSRLLAGYA VPRTGADLDP GRLRTALART LPDYAVPATV TVLPALPLGP
     TGKVDRAALP APATTTADDA PPTGAAAALA GLFADVLRLD APPGGDDSFF ALGGDSISSI
     QLVSRARQSG LVVSARQIFE HPTPRALAEV VAPHAPAGPR PAASGRDVPA AFTPLMHWLR
     RSPDHWGAFH QSMLVTVAST LTEGRLRTAI GHLLATHDLL RARVTTDHPD GRPRLTPLGP
     APDPATLLTV APVTGDDTEL RRAVDAQSRA RAGELDPEQG PLIRAVWFPR GPGRDGRLLL
     LVHHLAVDGV SWRILLPDLA HAVATGTPPA RPGTSFAHWA DALYGDPGRF AAERAHWDGV
     LADRPAPLVP PDAAGTPHTP GELRTELAPE LTAPLLTATA AAFHARPDEL LLAALVHAVG
     GDRPVLVDLE SHGRHEELVP GADLSRTVGW FTTQYPVRLE PGTGGVGQDV KHVRERLAAV
     PGRGAGYGAL HQQAPSGAQI AFNYLGRFTA DTPHGHWAPA PESDAVHPGP QPVLLGGHVL
     DLNASTLDGP RGPVLTVRWT YAADLIGPDR IRAVADRFTA ALTELVRRRD EPGFAGHSAA
     DFPVPLDQHE ITELETAVPA LDGVLPLTPL QHGLAYHALT EEAGTDPYVV QLELEITGPL
     DPDRLRAAAR DVMDRHANLR AGFRRLATGR LVQFTTADAP PQWTEHDLRA LPDAHPGRTA
     LVVDDRARPF APDRPPLLRF TLIRTAEDRW RLLFTSHHLL LDGWSTPLLL TDLFDAYAGL
     PPVRRRPYAD YARWLAGRDR PAAEAAWRAA LDGVTEPTLI APSGGPSTAL VPEETATVLD
     PALTAALQDR ARATGTTLNT LVQTGWGLVL SRITGRDDVV FASAVSGRPA ELDGVEGMLG
     LFVNTLPTRV RTAPARTLGE ALTDLHERQV ALLDHQHLGL ADIQGILGMP TLLDTMTVFE
     NYPFDDDALS RSESAAGLDV RGVGGRDATH YPLTLAITLQ GDRLRLVLKH RPDRYDTPAA
     RAVLDRLTRA LEHLAHRPDL PAGRLDLAPE TSAGLTGQPG APAALGCAGT VAAVAARTPD
     AIAVRPLDGG RPVTYAELVA RAARFADRLR DAGAGPEQVV ALLLPRSVDL VVAELAAAWT
     GAAYLPLHPD WPAERVRTVL GAAGAVALVA GPGGATAAYG PQPVLHPPAD HAPAGPPGVP
     PATAAPHRLA YVMYTSGSTG EPKGVAVPEA AVLALASDSR FAGDAHRRVL VHSPHSFDAA
     THEIWGTLLR GGELLLAPDA PLDPARWRSL LTGEEAAGPT ARRAAGKAAV AGAGSAWFTA
     GLFALLAQDA PETFTALREV WTGGDVVAPG AVAAAHAAAP GLRVVNGYGP TETTTFATAH
     PLDPEAPHAG PLPIGAPLDG TTLRVLDTAL RPSLPGVPGE LYIGGAGLAR GYHGRPAPTA
     ARFVADPHGR PGERLYRTGD LVRVRPDGAL DFLGRTDDQI KLRGHRVEPG ETEAALLAEA
     GVAGAAVVLR TDLPGGPALV AYAVPAPDTA LDTDALRARL AARLPDYQLP AHLVAVAVLP
     LTENGKLDRA ALPAPRTAEP AGPGHLPPHD QRTELLCRIF ADALGLPGFG PHEDFFERGG
     HSLSAMSLVG RARTLLDTEL SVGDLFTART PAATAALLRG ARGSARSPEP AHLPRPAEPP
     LSAAQQRLWF LHRLEEEPTA AYNVPIALRL TGTLDERALE QALADLTARH EVLRTVFPER
     EGRAVQRVLA PDDAPAPLTV RTTTPDALDA ALAGAATLPF ALERETPLRA ALFRVAPEGG
     AGPRHDVLLL VLHHIAGDEW SVRPLLDDLA TALAARSDGS APRWAALPLQ YADHTLRQRT
     LLGDEADEES EISRQVRYWR DQLAGLPAEL PLPVDRPRRP DTGHDGGIVE FALSAEVSAG
     LRRLASRTGA TPFMVAHAAL AVLLHRIGGT DDIPVGTLVA GRDDAAVHDL VGFFVNTLVL
     RTDVGGDPTP AQLVARARAA TLDALDHADV PFERLVDLLD VERSLERHPL FQVMLNYQTR
     TAEGPELGGL GSTPVAVHTH TAKFDLTVTL VQEPGADGVL NGGITYRTGL FDEATVRGIA
     DWYERVLAAF AERPERPVGG IRLLTEDQRH RLLDSWNSAE EPVRVLSVAR EFAERAALEP
     DAPAVIDGDR TVPYGELLRD ARSLAAPLRA HGVRRGEPVA VLLPRSAGLV TAAHAVLQAG
     GAYLPLDPDH PAARLSAMLD ANPPAVLLTD RAHRDLLPDG FDRPVLLLDD PRPPAPAGPA
     PAAPHPAQPA YILHTSGSTG RPKAVVVPHG ALANRLAWTQ RRFPLGPGDR MLAKAAPGFD
     VSVWELTGPL LAGAAVVVAG PDGHRDPACL VRLIREHGVH AVHFVPSMLA LFAAEPDAAH
     CTSLRWIFSG GEALTDTLVR RCAEVFAAPV VNQYGPTEAA VDVTARPAVP GEGPLVPLGA
     PGAGTRAYVL DAALRPVPPG VSGELYLGGA QLALGYSGRS AGTAERFVAD PFGAPGERLY
     RTGDLARWNG RGELEYLRRA DDQVKLRGVR IEPAEVRTAL LGHPDVRDAL VLVRDDLPSG
     AARLVGYVTP GDPAAPPLPA DLLAHGAKLL PAALVPSDVV VLDRFPLTVS GKVDRSALPA
     PAVADPAAGE RPKDPAEELL AELIADLLKL PAVGRESSFF ALGGDSITSI VLVSAARRRG
     LVISPRDVFE QRTVSALARV ARREEAAALV HDPGAGAVPL TPVMHALRRR GGDHRTYHQS
     LLVTTPPGLT AELLRRALGR LVAHHPVLAA RLDGAEDGTW TLRVPEDPAL ADDALTTVGS
     ASLADAITAA SRTAVGELDP YSGRMLRATL FDPGDGGPGR LLLVAHHLVV DAVSWRILLP
     DLAQLCAGPG ASLPPVETSF RTWSRALTAT AADRRAELPY WSEVLGGAGP APYGREPDPA
     TDTPDTVHRL ITTVPADLAE PALTEVTAAF HCTEQDVLLT AFVLAHSRWR NEESTLVLLE
     GHGRDAALPE VAAPARTVGW FTSQYPFRGR LTEAGPDTTI ADPNAAGRLL KQIKEQLRAV
     PDHGIGYGQL RHLDAASGAA LADRTEPLTG FNYLGRYDVG EADAAAPEPW TPSPESAAVW
     RPAPALGVHT AVDLDLTALR RPSGTELSVS WHHASRLVSD EEITVLDRWW RTALETLVAA
     ARTQAAGHTP SDLGLLTLSQ DEIDEFEDEW RTT
//

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