(data stored in SCRATCH zone)

SWISSPROT: B1VQH8_STRGG

ID   B1VQH8_STRGG            Unreviewed;      5808 AA.
AC   B1VQH8;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   30-AUG-2017, entry version 65.
DE   SubName: Full=Putative NRPS {ECO:0000313|EMBL:BAG17279.1};
GN   OrderedLocusNames=SGR_450 {ECO:0000313|EMBL:BAG17279.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17279.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17279.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00258}.
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DR   EMBL; AP009493; BAG17279.1; -; Genomic_DNA.
DR   ProteinModelPortal; B1VQH8; -.
DR   STRING; 455632.SGR_450; -.
DR   EnsemblBacteria; BAG17279; BAG17279; SGR_450.
DR   KEGG; sgr:SGR_450; -.
DR   eggNOG; COG1020; LUCA.
DR   HOGENOM; HOG000229991; -.
DR   OMA; NEVRRWV; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 5.
DR   Pfam; PF13193; AMP-binding_C; 5.
DR   Pfam; PF00668; Condensation; 7.
DR   Pfam; PF00550; PP-binding; 5.
DR   SMART; SM00823; PKS_PP; 5.
DR   SUPFAM; SSF47336; SSF47336; 5.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 5.
DR   PROSITE; PS50075; ACP_DOMAIN; 5.
DR   PROSITE; PS00455; AMP_BINDING; 5.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE   4: Predicted;
DR   PRODOM; B1VQH8.
DR   SWISS-2DPAGE; B1VQH8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001685}.
FT   DOMAIN     1000   1067       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     2072   2139       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     3128   3195       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     4182   4248       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     5230   5296       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   MOD_RES    1032   1032       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
SQ   SEQUENCE   5808 AA;  614941 MW;  D2AD93197652A655 CRC64;
     MRMSTHRERL PLTEAQLGLW SAQRIDPASP VYLTAEYVEL TGPLDERAFV AAVTRAVGEA
     DGLSVRFTAD GDDVHQETGA IPPTGPGLHD LRTAEDPGTA ALDWMEEERT APVDMEHGAL
     YRHALLRTGD ERWLWYHRCH HILLDAYGYA RVAERVAELY GHACAGTEPP ASPFAPLRDA
     VQEDRRYTDS EQHAADARFW QDLLADRPHP PTPARTAPTR VAPRSLRSRR TLGAADAERL
     AAFAQRSRAT WPEAVTAAWA LYLTRLTGTP EAVIGLPVSN RTGSVLARTP VTAVNVVPLR
     VAVDEREPVG DLLRRVTATL RRQRRHQRYR GERLRRDLQL FGHGRRLVGP QLNIKPFATD
     LAFGDCAGTV HSLAAGAVED LNVTVGGRGG PDGLTGLDLV LDGNPDLYGP AELDAHLHRF
     ATLLDRLSRA EPDLPGARVG LLDEPERLRV LEEFNAPDDG DAEAAPAPDL VEGFTDQARR
     TPHAVALRCG DAHLTYAELA DRAGRLASAL TARGAGRGSL IAVALPRGEA LLVALLAVAS
     AGAAYVPLDP RYPADRLRHM LADSRPLLLV TDRAHPWGAD LPRLTVALDG TLPDATPGAG
     TESLSAPADG VPAGPPRSGD PADRRPGDPA YVIYTSGSTG RPKGVVVPRP ALANLLAAMG
     RLLDLSGEDR LLAVTTVSFD IAALELFVPL LAGATVVLAA DDDVSDPFAL SALIRSSAPT
     VMQATPSLWR VLAEAAPDAL GGLRALSGGE PLPADLADVL SRHANGLVNL YGPTETTIWS
     TAAVLHRGTP PHVGRPVRRT RAHVLDRTLA PAPVGVTGEL HLAGDGVADG YLGRPALTAT
     RFVADPFGAP GARMYRTGDL ARYRDDGTLE VLGRADSQVK IRGHRVEPGE VEAALLAHPS
     VAEAAVAAVP APGGDLTLAA YCVLTRTGKE PGAGAAGEGD WADPLRHALA ERLPEHLVPG
     HFVALERLPL TPNGKTDRAA LPAVAPAAAP GAGRAPRAGA EALLCDLFAA VLGRSEASPD
     DDFFLLGGHS LSAARLVTAL RSRTGVELPV RALFDHPTPA RLADALERVG GLEGPGRTAG
     APPLVRRPRP ARPPLSFGQR RLWFLARSQG EDGSYNIPLA IDVAARLDPA ALRRALGDVA
     ARHEILRTVL PVEDGEAWQQ VLDITAAEPG LAEAHVREAR LGERVRAEAA RPFDVERETP
     LRAVLFTVEP DPAEPGSAEP GPCGAETVAP VRQTLLLVLH HIAADEWSLP LLLDDLAAAY
     AARLDGSDPH PPRLPVDHID FTLWQQDLVT ARQEADAQFW RTRMRGAPEQ LTLPWARPRP
     ARTGGPARTH DFGIDAELHQ RVKALARRTR TTTFMVLHAA FAATLSQLGC GDDLVIGTPV
     AGRDDEALRG SVGFLINTLP LRTRLDATTG FLDLLERTRD DDLAALAHRS LPLERIVAEV
     NPPRLPGVSP LFQVLFAVRE EFPDRAVLPG QTGRPRLVAT GAAKFDLQCT VSEDPATGAT
     GQLEYRTELW DAAAADRFAR ALLHVLDQLT AHPERPVATT PTGAGGAVAA PEPHPVPATS
     LAELCAAQAA RTPGRTALVS GADEITHADL DARSARLARL LADRGAGPGA LVGVSLPRGA
     DLLVTLLAVA RTGAAHLPVD PGFPAERIRM LLADAAPALL VTDRATARTL DADPRSVLLL
     DDPATVRAAA GAAPLAPRAA HGDAPAYVIH TSGSTGRPKG VVVTRAAVVN FLLCLADTLR
     FHGRERLLAV TTVGFDIAVL ELFLPLVTGA TVILADREQV RDPALLAELI DTARPTAMQA
     TPSLWRALLD TAPDAVRGLL ALAGGEALAP DLARRLVAHG ADLVNLYGPT ETTIWSTAGR
     LDATDAEAPH VGTPLWNTRA LVLGRGLVPL PVGVTGELYL AGDGLAQGYL GRPGQTAERF
     TADPCGPPGS RMYRTGDLAR LRADGALEIV GRADHQVKIR GHRVEPAEVA AALRAHPAVE
     DAAVVAHRGP ADPAPRLIAH LTGLTGSPEA RTATAARIRE ELRAVLPGHL VPDLCLPLDA
     LPLTPNGKLD RAALPAPRPA AAPVGRAPAG QGEELLAALF ADLLGLEQVG AEADFFALGG
     HSLLAARLAV RAAEALGRPL SVRQIFDTPT VAALAARPAA PETALPALEP VPHEGPLPLS
     PAQARLWFLS RLQPGTAYHL PFVLTLTGDV DHDALAAAVG DLAERHAVLR TVFPAADGAP
     VQHILDRPEP VRRRTARSAE EAEELLGALS AEPFDLAAEP PFRATVLAEP DRTRVLLLIH
     HIAADEWSVE PLLTDLSAAY RTRLAGGPPG LPPLGVAYTD YAHWQHALLD GGHLDGQAGF
     WRRTLRGAPA VLDLPTDRPR PETPTGRGGF VPFALPDEVA SGLRALAADA AVTPFMVTQA
     ALCALLAGLG AGDDIPLGVP TAGRGERRTE ELIGFFVNTL VLRTDLSGDP TFRELLARVR
     AVDLDAFDHA ELPFERVVEE LNPERGPANP LFQVMLTYQN RTSVPFTAPG VDAAFTLRET
     DTAKFDLIVG FTDHLADGSV DGAINYSADL FDATTVRALA DRLVAFLARA VARPDTRIGS
     IGLLTAGEED TLLRRWNPAG DHRGAPPVLD RFARAAADHP AAPALTDGGD TLTYAELDAR
     TNALARLLMS YGVGPEDRVA LLLPRSATLV EAVLAVAKTG AAYVPVDPAH PRDRIAWTLR
     DAAPALVVTD SATAGRTPAT CTAPVIVLDE EPHAGSRLRQ PDGPVADAER TGPQRQDNAA
     YLIYTSGSTG RPKGVVVTGR NLARLFDATA EDAFGPDDVW TLFHSYAFDF SVWEMWGALL
     HGGRLVIVPG AVTRSPDEFL ELLHHEGVTV LNQTPSACYQ LTEALTAPGS PGLPPALRLV
     VLGGEALDPA RLAPWLRDPE GPRLVNMYGI TETTVHVTTH DLAPGTPAPG ASPVGRAIDD
     LRVYVLDRRL RPVPPGVGGE LYVAGAGLSR GYRGRHPLTA ERFVADPFGA PGTRMYRSGD
     LARWSADGVL HYLGRADSQV SLRGFRVETA EIETVLRDPG GARSAAVLLR EDLPTGPGLV
     AYTTGGTPAD ALRAACAARL PAYMVPTAFV ALDRLPLTNN GKLDRAALPL PDTAPDGPPT
     GRAPRTPHEH LVARLYGEVL GRAPVAADED FFALGGHSLL VTRLAGRVRA ELGLDVPVRT
     LFEAPTVAAL AARLTGLTRT QDARVPGPAP AAVRPERLPL SPAQARLWFL HRLGGSALTY
     AVPLLLRLRG PLDESALGRA LAALARRHEI LRTCYPEHEG RPVQQVLPEA APVPLASALL
     DGESAQDAAR RLAAEPFDLA DRPPLRAHLL TGPGDERSLL LLVHHIAYDE ASTGPLVRDL
     ARLYAAELDP DHGAPEPPAL QYADYTLWHR EATAAREDGL LAYWRTALAG APEETSLPLD
     RPRPAEVDEH GDSVEFTVPA DLHRAAARLA RDNGATLFMV LQSALAVLLT GHGAGHDLPI
     GTLLSGRGER ALEELPGLIA NTVVLRTDTS GSPTFTELLA RVRAVDLDAF DHGDLPFERL
     VDALAPQRSL SRHPIFQVAL IHQNAPHRTL PFGPATVEAE LVETRAAKFD LTLAVVEEPG
     TDGLRAALNY RTALFDRPTV EALAHRLTTL LHRLCTHPGL PVDQVPVLDE AEARRVLTAS
     AGPHVPLPGR TLVDLVREQA ARSPAAEALR DGTRSWSYRE FDTEADRLAG LLAEHGVRRG
     DTVVVAVPRS AELVLAVHAV QRAGAAYLPV DPAQPAARVS SQLQDAEAVL LITDPAAALP
     GEAVGGLPVL DVTADEVPRF TTVLDGPRPA DPAYLLFTSG STGRPKGVRV PHDAVANRLR
     WAQDAYRLTE EDRVLLKTPA TFDVSVWELF WPLLAGATLV TAGPDDHRDP VAIARLLREH
     RVTTVHFVPS MLAAFTGTAA PADCATLRRV LASGETLTPA AAAGLLRLAP GAELHNLYGP
     TEAAVDVTAH PVTAADIASG RLPIGRPVWN TTTLVLDARL RPAPPGAAGE LYLAGAQLAY
     GYHRRAALTA TRFVADPYGP PGSRLYRTGD LARLRADGAL EHLGRVDDQI KLRGQRVEPG
     EIRAVLDAHH GIAAAAVVAH EDTATGVTHL IGYVVPRTGE GAALPAGLAE HLAARLPAHL
     VPTALIPLPA LPVTANGKLD RAALPAPRLT SPETRTAPRT DEELRLAALF AELLRTEHIG
     VDDSFFALGG DSILSIQLVA AARKAGLHFT PQDVFRHRTV AGLLAVAEPT TPAAPPRALP
     AAPDDGAPGR PTPLQEGLLF LSQYDGPGST GAGDPLDVYH VQVAIRLTGD LDTDRLRTAL
     RTVVRRHAPL RTAFTGDGNG WTQRVHTDPE PEFAVLDLRR RKPREQERRA ARRADDERRR
     RFDLSAPPLL RATLVRRPET CELVLTGHHL VLDGWSLPLL VRELLHTYAE RELPEPPDYV
     LHRAWLDARD EQSAAEAWRD ALDGVTEPTR LVPDDPGEQE LPDQQTVWVD AELTERIAAF
     GRERELTLST LTQAAWGLVL SAHTGRRDVV FGTVVSGRPA EVPGATEMIG LFVNTVPVRV
     TVRPQETLAA LAARLQDEFT ALLPHHHLGL AAIQRAAGHG VLFDTLTALE NYPADGIPAL
     AGATGLGLEE ITGRDATHYP LTFAAVPGER LALRVTHRPA AVTPARAREL AGRVEHLLRV
     LVTAPDTRVA ALDALTAAEH AELTADRAGP PAPAPRTWAR LVAEQRDRRP DAVAVDAPDG
     SLTYAQLDLR ARESAGTLRA AGIRPGQLVA VILPRSVDLV VAQLAVQQAG AAHLPIDPDY
     PEDRIAAMLQ DARPAGILTH RALADRYPTA LYTDAPPPAA AEASAATAPH PRHAPATDVT
     PDHPAYVIFT SGSTGRPKGV VTPHRGLTAL AAAQAERLGI DDGSRVLQLA SPSFDASVME
     TLMALATGAT LVVPEPGPLA GPLLGETIAR RRVSHALIPP TALTGLEPDG LDHLRTLIVG
     GEACTAPLTA RWAPGRRMIN AYGPTEATAC VTMSAPLAPG ATPPIGTPLH GVRVHVLDTL
     LRPVPPGGTG ELYVAGPGVA QGYLGRPRLT AERFTAEPGG PRGSRMYRTG DLVSRTPEGS
     LLYHGRADDQ VKIRGFRVEP GEIVAALQAR PEIRAAAVVL RQDDPAGPRR LVAYLVPAAP
     SGGSRPEAGR LDTAALRTAL ARVLPDHMVP SAFVGVPGLP VTANGKLDRD ALPAPDFGAA
     AGDTAPEGPA EETLAAIFAE VLGIPSVGAE DSFFTLGGDS ILSMRLVARA RAAGLRLTPR
     EVFELTSVRA LAALASGREP DPAAGPAASA LPDSGPAPLT PIMRWIAERP GPTGRFSQSM
     LLTLPPGITP AATAEVLGAV LRHHAVLRAR IDLDAGTFVV PEPADGPAPA LDEGPSATGA
     DPGALAREVD ELATGLDPSQ GLMVRARSYP GNAGEPGRLL LVVHHLAVDG VSWRILLDDL
     AQAWGDVSRG RAPHLPPATT SFRSWAHALG RQASARAGEL PVWQGILAAP DRLPAPASGR
     AEPPALGTVA DARHLVRTLD GAHTRTLLTG AAEHRGARVQ DLMLTALARA VREWSGRERV
     DFAAHVEGHG REQQIEDGAD LSRTVGWFTS LYPVRLAATA AEPPGDTLAR TRDHLARLPD
     SGIGYGLLRY AAQPPAGLRP EETDGPGAPL IAFNYLGRFG TAPTGGGAAW APAPGAGVLG
     GAVDAGLTMA HAVEINALTR DTPEGPLLDT RLTWAPAALD DRAAHALADC WQRALTALAA
     DAPPPPGPEP TTGPADPSAA RPTDRPAHGL SPLSPEQTAK LEAQWRNR
//

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