(data stored in SCRATCH zone)

SWISSPROT: B1VRR4_STRGG

ID   B1VRR4_STRGG            Unreviewed;      3477 AA.
AC   B1VRR4;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   30-AUG-2017, entry version 64.
DE   SubName: Full=Putative NRPS {ECO:0000313|EMBL:BAG17482.1};
GN   OrderedLocusNames=SGR_653 {ECO:0000313|EMBL:BAG17482.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17482.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17482.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00258}.
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DR   EMBL; AP009493; BAG17482.1; -; Genomic_DNA.
DR   RefSeq; WP_012377959.1; NC_010572.1.
DR   ProteinModelPortal; B1VRR4; -.
DR   STRING; 455632.SGR_653; -.
DR   EnsemblBacteria; BAG17482; BAG17482; SGR_653.
DR   GeneID; 6210296; -.
DR   KEGG; sgr:SGR_653; -.
DR   PATRIC; fig|455632.4.peg.636; -.
DR   eggNOG; ENOG4105C0W; Bacteria.
DR   eggNOG; COG1020; LUCA.
DR   HOGENOM; HOG000229991; -.
DR   OMA; RTLKVHW; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   Pfam; PF00501; AMP-binding; 3.
DR   Pfam; PF13193; AMP-binding_C; 3.
DR   Pfam; PF00668; Condensation; 3.
DR   Pfam; PF00550; PP-binding; 3.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 3.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF47336; SSF47336; 3.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 3.
DR   PROSITE; PS50075; ACP_DOMAIN; 3.
DR   PROSITE; PS00455; AMP_BINDING; 3.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   4: Predicted;
DR   PRODOM; B1VRR4.
DR   SWISS-2DPAGE; B1VRR4.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001685}.
FT   DOMAIN      977   1044       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     2044   2111       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     3133   3200       Carrier. {ECO:0000259|PROSITE:PS50075}.
SQ   SEQUENCE   3477 AA;  371232 MW;  7E0EADC25C6CBF01 CRC64;
     MTDVPHNGTP AGTVRLTAAQ RGVWFAQRLA PSDPSYNIAE YADIKGPVDA GLLSRAVNRT
     AREMEALRST FGELNGVPFQ RVEERAALTV PLVDLSDEED PYGEALRRMR LCLAEPADLS
     AGPLVRVTLY RLSPSHHLFH QQVHHVALDG YAAVLALSRI AEVYTALALT PGTLPEHRPA
     ASLATIIEEE DAYLASEQAV EDERFWTAHL AGAHPPEAPA GAGDGKTYGT VSVRRVYSRV
     ETDRLKAAAK RAGTGWPTFV MAALALCLHR EKGLGEVVLG LPVTGRRTPA ARSTPTMLSS
     ILPMRLSVSP SDRVSDLARR ASAEARSVLR HQRRPAEALR HQSGLTGTRA PLTGPSVNIL
     AFDDTLRFGA HRATLHNLSI GPVEDLAVAV HASFGDGGLD IDLLGNAQLY GRQDLVGPHE
     RLCRVLDAFV ADPERSIGAL SPVDEDEQRQ VLGLGAARPS SDDAAIPAPL SELFDRQARE
     TPHRTAVVCD GATLTFDELN RRVKALAAEL SARRARPGTR VAVGLPRSID LVVAILAVMR
     TGAAYLPLDP SYPVDRLAFM IEDSQPVALV ATASSAHTID PHASIPRVDP GTVQLGTVEP
     VGVPGPELHD AAYVIYTSGS TGRPKGVVVE HRSLSNLLEH HRREAHHLAE EALERRLRVA
     LSAATSFDAS WDPVLWMVAG HELHVIADDV RRDPQALVRY LVDHRIDAIE TTPTYLRQMM
     TAGLLASGTH RPRVIALGGE PVDEGLWEEL AADPDLLVFN FYGPTETTVN AVTARITGRS
     PVIGRPVAGA GAYVLDPSLH PLPRGSVGEL YLAGEGLARG YAGRPGLTAE RFMPDPFGVP
     GARMYRTGDL ARWDADGSLE FLGRSDRQIK VRGVRVETGE IEAALRSLPG VDDAAVALTT
     APDGPERLAA FLVAGPDAPA HAQARDTVAA LLPGPLVPTA WATVERLPLT PNGKLDVAAL
     PPAVPVASDG GTPRSAQEAR MCAVFAACLG VTRVGRDDDF FTLGGHSLLA MLLIGRIRGE
     FGVEIPISAL FAAPTPAGLV AALGEAGAAR RPVAAFVPRP ERIPLSFGQQ RLWLLESLGD
     AGTSYHLPVA LRLRGPLDRD ALELALRDIV ERHEALRTVV TAAPEGPHQR ILPPQRIPRP
     LLRVMPAGEP AAPDGVPFDL EREIPLRARL FSVNAEDHVL VVTLHHIAAD GWSMGPLMRD
     LSAAYGARRA GRTPGWDRLP LQYADFALWQ RDLLGAPDAP DSLARRQLSA WADSLAGLPE
     ESVFPADRPR PERPSGRGGA VPVQITPDVH RMLVELARVS EASSFMALHA ALAGLMSRLG
     AGEDIAIGTP IAGRTDEALG ELVGFFVNTL VLRADVSGAP SFRTLVGRVS ESDLAAYAHQ
     DIPFERIVEE LAPPRSLARH PLFQVMLSLN NTPGPRPHLD GLSVSRAMSV GRTGSKFDLS
     WDLSEQHDEE GRPQGITGEL EYDEDLFDKA TAERFVEHFT RLLSALLSEP DRPVADLDFL
     TPAQRAAALD ELPRTTTRPL SATTVAVGGD WTVLDVLATR AAVQPDRTAV VADDSRLTFG
     ELRLRTDRLA ASLVDRGVGP GDRVAVALPR TSLAVVALLG ILRAGAVYVP LDTAQPAARS
     ELVIDTAAPR LVLATSATSA VLPDTVDVVL LDGAGQEAAL PAAGLPAPPR GRDAAYVLYT
     SGSTGLPKGV VVEHHSLAAL LAHHRDRLMG PAEAANNGLP LRVAHTAAMT FDASLDPLLW
     MIAGHELHLV DDTTRRDPEA LTALLHERAI DVVETTPSYL EQLRACGLFA PGRPRPRVLA
     LGGEAIPPPL WRELAGLSDV TVWNLYGPTE TTVDSVMGRV LPGVRPHLGH PVTGARVLDR
     RLRPVAPGVT GELYVSGPGV ARGYEGRSAA TAERFLPDPH GVPGSRMYRT GDLVRRVEGR
     LEYLGRADGQ IKIRGFRVET GEVASALDAH EDIARSAVAV RSDAGSGEAQ LVGWVVPAGH
     RDLSPRELRS FVARRLPAHM VPSLIVPVDS LPLTAHGKVD FSALPSAAPA GSPEETGRAP
     RSAPEEILCA LFAESLGHEQ VSPDDDFFEL GGHSLLATRL VGRIRSAFGV ELPVRALFES
     TTPAGLTERL AKAGGSARPA LRRTRHTEQP PLSPAQERLW FLHQLDPRAA AYHMAFTVRL
     TGALDQNALR SALGDVLTRH ESLRTVIEPA GGRPCQRILA PGDARPELPL VTVVDETHLG
     GALREAAAEP FDLERDVPLR PVLFRSAADR HTLLVTVHHI AADGWSMGPL AQDLAGAYAA
     RTAGRAPSWN PLPVQYADYT RWQRDLLGDF TDPTSTASAQ LAYWEDRLSA APEETALTAD
     RPRPASPSGL GGTVAVRVPE ETMAGVARLA KSTASSTFMV LHAALAALLH RMGGDSDVLI
     GTPVAGRTDE ALDPLVGFFV NTLALRTDLG GNPDFTELLS RVRETDLAAY AHQELPFERL
     VEAVRPTRSL SRHPIFQVML TLNNHRPPRL DLPGLQARLE AVDTGGAKFD LSFSFTERAS
     ATGDGSCLDG TLEYSRDLFD ADTAVRIAER FALLLADAVG DPGTAIGDLP LVGAEEQRRL
     LAIGESRGPS MADPTLFTTV LDRFAATVAS ARSGDIAVTA PDGSLSFTEL DARSERIAEV
     LLQAGAGQRD PVAVLLPRSA DSIAALLGVL KAGAVYVPVD GSLPQGRIDA VLADAHPHTV
     LTADGTHDLA RGHGRRLNLY SPECAATLSD GPAPVREQKR PGPGEPAYLL HTSGSTGRPK
     GVLVGHGSLA RLLEHHRRRV FAPAVRAAGK PQLNIALTAA LSFDAAWDPV LWMIDGHRLH
     VLDDLTRRDP EALVHAARVH GFDVLESTPT HVRQLLDAGL FSEDGPAPSV IALGGEAVPA
     ALWDDLRSQP GLTAWNFYGP TEATVDTLTA DLRAADRPVL GSPVDGTSVR LLDDRLRPVP
     VGVAGELYLA GDSLALGYQG QPAETATRFV PDPHGPSGAR MYRTGDRAVR RSDDALEFVG
     RADGQVKVRG FRVEPEGVAA VLTEHADAAQ AAVVAHGEGP GGSRLAAYIV LTERSAAPAR
     TAPKGPADAS RSEADRLNAI REYAAARLPA YMVPSGWVAL DAIPLTPNGK LDRAALPAPR
     ADAGNGRSPR NPREDVLCTL FAETLELERV LIDDDFFELG GHSLLAAGLI RRIRDALGVD
     VSIRSLFEAP TVAALAERIG AGVQDNPLAT LLPLRTRGTL PPLFCVHPAG GLAWAYAGLL
     PHLENDRPLY GLQTPNLDGT RPFPDSIEAM AAVYVAELRA VQPHGPYHLF GWSFGGNVVQ
     EVAVQLQEAG EEVALLTILD AFPLAPLDDL DRASRDTVFR ALLSNMGVGQ EALAGDGPVE
     AGDVRDQFRA NGSPLGALEP ATIDAMVDNF AGQARLMRRY TPRVFHGPAL FFTAAEGRPA
     DTFDLSLWNP YITGPIENHD VACAHAQMMQ PAAREQIGTT VTAVLTAYQH TERGDLS
//

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