(data stored in SCRATCH zone)

SWISSPROT: B1VRZ6_STRGG

ID   B1VRZ6_STRGG            Unreviewed;       539 AA.
AC   B1VRZ6;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   08-MAY-2019, entry version 78.
DE   SubName: Full=Putative two-component system sensor kinase {ECO:0000313|EMBL:BAG17564.1};
GN   OrderedLocusNames=SGR_735 {ECO:0000313|EMBL:BAG17564.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17564.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17564.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; AP009493; BAG17564.1; -; Genomic_DNA.
DR   RefSeq; WP_012378024.1; NC_010572.1.
DR   STRING; 455632.SGR_735; -.
DR   EnsemblBacteria; BAG17564; BAG17564; SGR_735.
DR   GeneID; 6215521; -.
DR   KEGG; sgr:SGR_735; -.
DR   PATRIC; fig|455632.4.peg.723; -.
DR   eggNOG; ENOG4105BZU; Bacteria.
DR   eggNOG; ENOG410XNMH; LUCA.
DR   HOGENOM; HOG000048503; -.
DR   OMA; DQYIAFA; -.
DR   OrthoDB; 1755994at2; -.
DR   BioCyc; SGRI455632:G1G2X-734-MONOMER; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR007891; CHASE3.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF05227; CHASE3; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; B1VRZ6.
DR   SWISS-2DPAGE; B1VRZ6.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:BAG17564.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     20     43       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    198    217       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      219    271       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      300    515       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   COILED      256    283       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   539 AA;  59116 MW;  F44296A2643EA48E CRC64;
     MTKQPAPGGF AARLSVQNWV HLILGGFIVV VCACLVIGGL VMARISDRTT ELVDRIQPAR
     SASFQLQNAL LDQETGIRGF ALTGDDSFLE PYEAGKAAEQ ERLAQVRRLV GSGGRYADDL
     DAIAAAAEQW RRSKAEPLIA TVREQGPSEA ATSARLQRSK ADFDQLRQAY GAQQGHLAEA
     RDRARADLGS ARTTRDQVMI ALVTVFVLTV AALSLLLHRV VGVPLTRLRT ASDRVRSGAF
     GTRIEINGPS DVQAVARTVE DMRRRLADEL SEAQSREALL AEQTDELRRS NSELEQFAYV
     ASHDLQEPLR KVASFCQLLE KRYGKELDDR GKQYIAFAVD GAKRMQVLIN DLLTFSRVGR
     VQEGWKPVDL DRSLDRALGN LAVAIEESGT VIERPESLPE LLGDATALTM VWQNLVGNAV
     KFRREGVPCR ISVTCVQEGE DWHLTVSDNG IGIAPEFADK VFVIFQRLHA RDEYDGTGIG
     LALCRKIIEF HGGRIWLEPE PGEGTRFHFT LPVAPEAPTH TAAELLAPAL LTSQPGDPS
//

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