(data stored in ACNUC31108 zone)

SWISSPROT: B1WAT5_XENTR

ID   B1WAT5_XENTR            Unreviewed;       253 AA.
AC   B1WAT5;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   08-MAY-2019, entry version 76.
DE   RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
GN   Name=cd151 {ECO:0000313|EMBL:AAI61493.1,
GN   ECO:0000313|Ensembl:ENSXETP00000041276,
GN   ECO:0000313|Xenbase:XB-GENE-480009};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI61493.1};
RN   [1] {ECO:0000313|EMBL:AAI61493.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Whole embryo {ECO:0000313|EMBL:AAI61493.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000041276}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000041276};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [3] {ECO:0000313|Ensembl:ENSXETP00000041276}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361218};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361218}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000256|RuleBase:RU361218, ECO:0000256|SAAS:SAAS01169470}.
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DR   EMBL; AAMC01052796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC161493; AAI61493.1; -; mRNA.
DR   RefSeq; NP_001116919.1; NM_001123447.1.
DR   STRING; 8364.ENSXETP00000041276; -.
DR   Ensembl; ENSXETT00000041276; ENSXETP00000041276; ENSXETG00000019035.
DR   GeneID; 100144686; -.
DR   KEGG; xtr:100144686; -.
DR   CTD; 977; -.
DR   Xenbase; XB-GENE-480009; cd151.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00940000157760; -.
DR   HOGENOM; HOG000230651; -.
DR   KO; K06537; -.
DR   OMA; QXGGCIT; -.
DR   OrthoDB; 1051357at2759; -.
DR   TreeFam; TF352892; -.
DR   Reactome; R-XTR-2022090; Assembly of collagen fibrils and other multimeric structures.
DR   Reactome; R-XTR-446107; Type I hemidesmosome assembly.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000019035; Expressed in 13 organ(s), highest expression level in embryo.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; B1WAT5.
DR   SWISS-2DPAGE; B1WAT5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Membrane {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00429796};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Transmembrane {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00028015};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00429788}.
FT   TRANSMEM     21     43       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM     55     80       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM     92    115       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM    220    245       Helical. {ECO:0000256|RuleBase:RU361218}.
SQ   SEQUENCE   253 AA;  28532 MW;  ED291B618466DD90 CRC64;
     MSEYNEKKET CGTICLKYLL FTFNFFFWLA GLAVMAVGIW TLIQKSDYIS LLPSNTYAAT
     AYILVIAGAI VMITGILGCC ATFKERKSLL KVYFILLLCI FILEVLAGIL AYIYYQQLNA
     ELKQSLKQTM TTKYKQPGEE KVTNAVDKLQ QEFKCCGSNN SEDWRDSIWI NSPEAEKRLV
     PDSCCKTVTQ RCGIRDHPSN IYKTEGGCIT KLETFIRAHL LIIGAVGIGI ACVQLFGMIF
     TCCLYRSLKS EPY
//

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