(data stored in ACNUC1104 zone)

SWISSPROT: B2HRG9_MYCMM

ID   B2HRG9_MYCMM            Unreviewed;       626 AA.
AC   B2HRG9;
DT   10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT   10-JUN-2008, sequence version 1.
DT   10-APR-2019, entry version 62.
DE   SubName: Full=Drug-transport integral membrane protein {ECO:0000313|EMBL:ACC42600.1};
GN   OrderedLocusNames=MMAR_4192 {ECO:0000313|EMBL:ACC42600.1};
OS   Mycobacterium marinum (strain ATCC BAA-535 / M).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC42600.1, ECO:0000313|Proteomes:UP000001190};
RN   [1] {ECO:0000313|EMBL:ACC42600.1, ECO:0000313|Proteomes:UP000001190}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX   PubMed=18403782; DOI=10.1101/gr.075069.107;
RA   Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA   Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T.,
RA   Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N.,
RA   Jagels K., Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA   Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L.,
RA   Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT   "Insights from the complete genome sequence of Mycobacterium marinum
RT   on the evolution of Mycobacterium tuberculosis.";
RL   Genome Res. 18:729-741(2008).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS00769108}.
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DR   EMBL; CP000854; ACC42600.1; -; Genomic_DNA.
DR   RefSeq; WP_012395765.1; NC_010612.1.
DR   STRING; 216594.MMAR_4192; -.
DR   EnsemblBacteria; ACC42600; ACC42600; MMAR_4192.
DR   KEGG; mmi:MMAR_4192; -.
DR   eggNOG; ENOG4105C0R; Bacteria.
DR   eggNOG; ENOG410XNN3; LUCA.
DR   HOGENOM; HOG000239124; -.
DR   OMA; SWLCGIS; -.
DR   OrthoDB; 1108236at2; -.
DR   BioCyc; MMAR216594:GJOB-4167-MONOMER; -.
DR   Proteomes; UP000001190; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; B2HRG9.
DR   SWISS-2DPAGE; B2HRG9.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00769078};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001190};
KW   Membrane {ECO:0000256|SAAS:SAAS00769060, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001190};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00769091,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00769070,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00769034}.
FT   TRANSMEM     20     41       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     53     74       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     86    113       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    144    168       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    174    194       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    206    222       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    234    252       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    273    296       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    308    329       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    336    355       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    367    389       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    410    428       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    466    484       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       20    488       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   626 AA;  66232 MW;  44AE6992470F4E74 CRC64;
     MTAVTSRVLD NGYSGNPWNA LSAMMIGFFM IMLDSTIVSI ANPTIMAELH IGYADVVWVT
     SAYLLGYAVV LLVAGRLGDR FGPKNLYLIG LSVFTAASMW CGLAGTAAML IAARTVQGIG
     AGLLTPQTLS TITRIFPATR RGAALSLWGA AAGVASLVGP LIGGVLVSGL GWEWIFFVNI
     PIGLAGLVVA YLLVPDLPVH AQRFDLIGVG LSGAGMFLLV FGLQEGQAAD WAPWIWAVLV
     AGVGFMAMFV YWQALNHRAP LISLAIFRDW EFSLCNIGVG ITAFATTAPM LPLTFYAQSV
     CGLSPARAAV LIAPVALASG VLAPVVGMLV DRSHPLPVLG FGFSALAISM TWLSIEMVPE
     TPVWRLVLPF AAMGAGMAFV WSPLAATATR NLPAHLAGAG SGVYNATRQL GAVLGSASMA
     AFMTWRITAE MPPGFDADRG FSGGDGGLQL PEVVRTPFSA AMSQSMLLPA FIAVFGIIAA
     LFLVRSRTAP VRAHDRASHA DDDHVDRGDY GYGDYGEQDD FGEQDDYDDY VEFVLRPEPA
     VGTHRHTEIR RPLSGASGNG PAVAGRGQQP HSARFEKWRD DAADGHAAPI EHNGARVDAR
     RRFRPVADFL PAPDQDDAAG SGHSLP
//

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