(data stored in ACNUC7421 zone)

SWISSPROT: B2HSK3_MYCMM

ID   B2HSK3_MYCMM            Unreviewed;       257 AA.
AC   B2HSK3;
DT   10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT   10-JUN-2008, sequence version 1.
DT   30-AUG-2017, entry version 54.
DE   SubName: Full=Enoyl-CoA hydratase, EchA5 {ECO:0000313|EMBL:ACC39461.1};
GN   Name=echA5 {ECO:0000313|EMBL:ACC39461.1};
GN   OrderedLocusNames=MMAR_1004 {ECO:0000313|EMBL:ACC39461.1};
OS   Mycobacterium marinum (strain ATCC BAA-535 / M).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC39461.1, ECO:0000313|Proteomes:UP000001190};
RN   [1] {ECO:0000313|EMBL:ACC39461.1, ECO:0000313|Proteomes:UP000001190}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX   PubMed=18403782; DOI=10.1101/gr.075069.107;
RA   Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA   Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T.,
RA   Churcher C., Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N.,
RA   Jagels K., Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA   Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L.,
RA   Brosch R., Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT   "Insights from the complete genome sequence of Mycobacterium marinum
RT   on the evolution of Mycobacterium tuberculosis.";
RL   Genome Res. 18:729-741(2008).
RN   [2] {ECO:0000213|PDB:3QKA}
RP   X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 2-256.
RX   PubMed=25613812; DOI=10.1016/j.tube.2014.12.003;
RA   Baugh L., Phan I., Begley D.W., Clifton M.C., Armour B., Dranow D.M.,
RA   Taylor B.M., Muruthi M.M., Abendroth J., Fairman J.W., Fox D.,
RA   Dieterich S.H., Staker B.L., Gardberg A.S., Choi R., Hewitt S.N.,
RA   Napuli A.J., Myers J., Barrett L.K., Zhang Y., Ferrell M., Mundt E.,
RA   Thompkins K., Tran N., Lyons-Abbott S., Abramov A., Sekar A.,
RA   Serbzhinskiy D., Lorimer D., Buchko G.W., Stacy R., Stewart L.J.,
RA   Edwards T.E., Van Voorhis W.C., Myler P.J.;
RT   "Increasing the structural coverage of tuberculosis drug targets.";
RL   Tuberculosis 95:142-148(2015).
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
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DR   EMBL; CP000854; ACC39461.1; -; Genomic_DNA.
DR   RefSeq; WP_012392916.1; NC_010612.1.
DR   PDB; 3QKA; X-ray; 2.15 A; A/B/C/D/E/F=2-256.
DR   PDBsum; 3QKA; -.
DR   ProteinModelPortal; B2HSK3; -.
DR   SMR; B2HSK3; -.
DR   STRING; 216594.MMAR_1004; -.
DR   EnsemblBacteria; ACC39461; ACC39461; MMAR_1004.
DR   KEGG; mmi:MMAR_1004; -.
DR   eggNOG; ENOG4105E6Z; Bacteria.
DR   eggNOG; COG1024; LUCA.
DR   HOGENOM; HOG000027939; -.
DR   KO; K01692; -.
DR   OMA; TFCAGFD; -.
DR   OrthoDB; POG091H01K6; -.
DR   Proteomes; UP000001190; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom.
DR   InterPro; IPR001753; Crotonase_core_superfam.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   1: Evidence at protein level;
DR   PRODOM; B2HSK3.
DR   SWISS-2DPAGE; B2HSK3.
KW   3D-structure {ECO:0000213|PDB:3QKA};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001190};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001190}.
SQ   SEQUENCE   257 AA;  26684 MW;  F7D59D49F1F78F54 CRC64;
     MSDLVQVERN GPVTTVIINR PQARNAVNGP TAAALYSAFA EFDRDESASV AVLCGNGGTF
     CAGADLKAFG TAEANAVHRT GPGPMGPSRM MLSKPVIAAV SGYAVAGGLE LALWCDLRVA
     EQDAVFGVFC RRWGVPLIDG GTVRLPRLIG HSRAMDMILT GRAVQADEAL AIGLANRVVP
     NGQARQAAEE LAAQLAALPQ QCLRSDRLSA LQQWGLPESA ALDLEFASIS RVAAEALEGA
     GRFAAGAGRH GAQASHD
//

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