(data stored in SCRATCH zone)

SWISSPROT: B2UH72_RALPJ

ID   B2UH72_RALPJ            Unreviewed;       317 AA.
AC   B2UH72;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   08-MAY-2019, entry version 78.
DE   RecName: Full=Proline iminopeptidase {ECO:0000256|PIRNR:PIRNR006431, ECO:0000256|RuleBase:RU003421};
DE            Short=PIP {ECO:0000256|PIRNR:PIRNR006431};
DE            EC=3.4.11.5 {ECO:0000256|PIRNR:PIRNR006431, ECO:0000256|RuleBase:RU003421};
DE   AltName: Full=Prolyl aminopeptidase {ECO:0000256|PIRNR:PIRNR006431};
GN   OrderedLocusNames=Rpic_3807 {ECO:0000313|EMBL:ACD28923.1};
OS   Ralstonia pickettii (strain 12J).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=402626 {ECO:0000313|EMBL:ACD28923.1, ECO:0000313|Proteomes:UP000002566};
RN   [1] {ECO:0000313|Proteomes:UP000002566}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12J {ECO:0000313|Proteomes:UP000002566};
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T.,
RA   Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Marsh T., Richardson P.;
RT   "Complete sequence of chromosome 2 of Ralstonia pickettii 12J.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of N-terminal proline from a peptide.;
CC         EC=3.4.11.5; Evidence={ECO:0000256|PIRNR:PIRNR006431,
CC         ECO:0000256|RuleBase:RU003421};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006431}.
CC   -!- SIMILARITY: Belongs to the peptidase S33 family.
CC       {ECO:0000256|PIRNR:PIRNR006431, ECO:0000256|RuleBase:RU003421}.
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DR   EMBL; CP001069; ACD28923.1; -; Genomic_DNA.
DR   RefSeq; WP_012429969.1; NC_010678.1.
DR   STRING; 402626.Rpic_3807; -.
DR   ESTHER; ralpj-b2uh72; Proline_iminopeptidase.
DR   MEROPS; S33.001; -.
DR   EnsemblBacteria; ACD28923; ACD28923; Rpic_3807.
DR   GeneID; 6284898; -.
DR   KEGG; rpi:Rpic_3807; -.
DR   PATRIC; fig|402626.5.peg.50; -.
DR   eggNOG; ENOG4105EGK; Bacteria.
DR   eggNOG; ENOG410XPKQ; LUCA.
DR   HOGENOM; HOG000171480; -.
DR   KO; K01259; -.
DR   OMA; PDKWERF; -.
DR   OrthoDB; 665798at2; -.
DR   BioCyc; RPIC402626:GH94-3817-MONOMER; -.
DR   Proteomes; UP000002566; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR002410; Peptidase_S33.
DR   InterPro; IPR005944; Pro_iminopeptidase.
DR   PANTHER; PTHR43722; PTHR43722; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PIRSF; PIRSF006431; Pept_S33; 1.
DR   PRINTS; PR00111; ABHYDROLASE.
DR   PRINTS; PR00793; PROAMNOPTASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   TIGRFAMs; TIGR01249; pro_imino_pep_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; B2UH72.
DR   SWISS-2DPAGE; B2UH72.
KW   Aminopeptidase {ECO:0000256|PIRNR:PIRNR006431,
KW   ECO:0000256|RuleBase:RU003421, ECO:0000313|EMBL:ACD28923.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002566};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR006431};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR006431,
KW   ECO:0000256|RuleBase:RU003421, ECO:0000313|EMBL:ACD28923.1};
KW   Protease {ECO:0000256|PIRNR:PIRNR006431,
KW   ECO:0000256|RuleBase:RU003421};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002566}.
FT   DOMAIN       41    296       AB hydrolase-1. {ECO:0000259|Pfam:
FT                                PF00561}.
FT   ACT_SITE    113    113       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006431-1}.
FT   ACT_SITE    268    268       {ECO:0000256|PIRSR:PIRSR006431-1}.
FT   ACT_SITE    296    296       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006431-1}.
SQ   SEQUENCE   317 AA;  35702 MW;  219C7B6D079B4CF9 CRC64;
     MSELRTLYPP IEPYETGMLD VGDGHTIYYE RVGTPGAKPA VFLHGGPGGG ISPDHRRVFD
     PARYDVMLFD QRGCGRSTPY AGLEANTTWH LVADIERLRA MVGAERWLVF GGSWGSTLAL
     AYAQKSPERV SELVLRGVYT VTQAELRWYY QYGVSEMFPE KWARFQAPIP EAERGDMIAA
     YRKVLTGEDR ARQIEAARAW SVWEGETITL LPDPGNSAKH ADDHFALAFA RLENHYFTHQ
     CWLEEGQLLR EAQRLAGIPG VIVHGRYDMP CPVRYAYALH QAWPDADFYL IEGAGHAWTE
     PGILDQLVAA TDRFADR
//

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