(data stored in SCRATCH zone)

SWISSPROT: B3L717_PLAKH

ID   B3L717_PLAKH            Unreviewed;      3029 AA.
AC   B3L717;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   11-DEC-2019, entry version 63.
DE   SubName: Full=Guanylyl cyclase, putative {ECO:0000313|EMBL:CAQ40690.1};
DE            EC=4.6.1.2 {ECO:0000313|EMBL:CAQ40690.1};
GN   ORFNames=PKH_111030 {ECO:0000313|EMBL:CAQ40690.1};
OS   Plasmodium knowlesi (strain H).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=5851 {ECO:0000313|EMBL:CAQ40690.1, ECO:0000313|Proteomes:UP000031513};
RN   [1] {ECO:0000313|EMBL:CAQ40690.1, ECO:0000313|Proteomes:UP000031513}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H {ECO:0000313|EMBL:CAQ40690.1,
RC   ECO:0000313|Proteomes:UP000031513};
RA   Pain A., Boehme U., Berry A.E., Mungall K., Finn R., Jackson A.P.,
RA   Mourier T., Mistry J., Pasini E.M., Aslett M., Balasubrammaniam S.,
RA   Borgwardt K., Brooks K., Carret C., Carver T.J., Cherevach I.,
RA   Chillingworth T., Clarke T.G., Galinski M.R., Hall N., Harper D.,
RA   Harris D., Hauser H., Ivens A., Janssen C.S., Keane T., Larke N., Lapp S.,
RA   Marti M., Moule S., Meyer I.M., Ormond D., Peters N., Sanders M.,
RA   Sanders S., Sergeant T.J., Simmonds M., Smith F., Squares R., Thurston S.,
RA   Tivey A.R., Walker D., White B., Zuiderwijk E., Churcher C., Quail M.A.,
RA   Cowman A.F., Turner C.M.R., Rajandream M.A., Kocken C.H.M., Thomas A.W.,
RA   Newbold C.I., Barrell B.G., Berriman M.;
RT   "The genome of Plasmodium knowlesi strain H, a zoonotic malaria parasite
RT   with host range from monkey to man.";
RL   Nature 455:799-803(2008).
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DR   EMBL; AM910993; CAQ40690.1; -; Genomic_DNA.
DR   RefSeq; XP_002261285.1; XM_002261249.1.
DR   EnsemblProtists; CAQ40690; CAQ40690; PKH_111030.
DR   GeneID; 7321791; -.
DR   KEGG; pkn:PKH_111030; -.
DR   EuPathDB; PlasmoDB:PKNH_1110800; -.
DR   HOGENOM; HOG000281712; -.
DR   InParanoid; B3L717; -.
DR   KO; K01769; -.
DR   OMA; HHNNNKY; -.
DR   Proteomes; UP000031513; Chromosome 11.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR032630; P_typ_ATPase_c.
DR   Pfam; PF00211; Guanylate_cyc; 2.
DR   Pfam; PF16212; PhoLip_ATPase_C; 1.
DR   SMART; SM00044; CYCc; 2.
DR   SUPFAM; SSF55073; SSF55073; 2.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   SUPFAM; SSF81653; SSF81653; 1.
DR   SUPFAM; SSF81665; SSF81665; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE   4: Predicted;
DR   PRODOM; B3L717.
DR   SWISS-2DPAGE; B3L717.
KW   Coiled coil {ECO:0000256|SAM:Coils}; Lyase {ECO:0000313|EMBL:CAQ40690.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031513};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        62..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        96..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        299..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        342..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1031..1050
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1062..1085
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1106..1130
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1136..1155
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1167..1190
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1210..1226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1349..1371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1383..1404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1411..1430
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1450..1477
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1514..1534
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2642..2660
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2672..2693
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2713..2734
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2746..2767
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2773..2791
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        2798..2817
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1597..1766
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   DOMAIN          2870..3004
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          1862..1887
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2061..2083
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2161..2190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2281..2328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2348..2385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2402..2447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2462..2495
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2534..2563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          605..625
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        2061..2075
FT                   /note="Basic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2170..2190
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2281..2306
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2356..2371
FT                   /note="Basic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2470..2495
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3029 AA;  354081 MW;  176616660FEAEC31 CRC64;
     MKSTKRMKTQ ALTLMHLDGK RKYIGTGNNI YRKVVINPTS EDDLQKFCRN YFRIYNFSLY
     NFIRRLISLD AVVVYSLFLT VYVFSEISQG ITKKFIFMDT AISMFLNIAI LVVTETLYEL
     KHLKDIKDAN SQCYLRIVPK MSHFEKVTTK DIKVGDIIRV FQGDEFPADA VILYVKNNLN
     AMVDSFKIDG LFRKSIKYPV DKYKIDRDYL KMLSEINGFI RCELPNKNIF CFQGNFKLDK
     HPRSLMLSYE NFALQSSILK GAEYIDAVVV YTGADTKKNL NIPQKTEESR TFCIKMNNVV
     YYLIFMYLFF VLLSIIIKLT FYPTREFHQS TNDTFLTILE DFIGLYILVL PIMIYSEKSL
     IYIIQSLKIE NNLRLKEGPN DEKPKVFNKN KNDALGAVDL LATARNGILV KKKEVFVSCA
     VNNVVYAKYD FVHSRGEFRL PTLNILDGER RNVAELLNLD ERIFKDPESV LFPSRDLGLF
     LRIFQNRMAP IYNPFVDDLS MVLREKYRSY LKEEILNKNV KLTPFVKSKL NGGYNQFYEN
     FKNNYNCKEV IEDARRGEDQ TNKIEEFVLG ICGCNRVIIY NEKCLDMGMR EYKSENYNDA
     YGKYEKENTN EIENEKNEKN TEEADEENFH TIEYEDICLY NIVKNIGYHV YCYKNRLFFY
     NLKNQCQEYH LICFHDFLKS NKFSMCILKD IKELDKGILY VRGYDFNILP YLSLAKNDIS
     KIKKIIKLYT MNYLKVIMIC KKTIKNEDIG KYLLLKSIRN SNNSRLSLRL YDLMKIFLLN
     DLEVVGMIGL KNDLKEGVED AFLDLAKFDI RSWIFTNEYS KNTYLTALEC NLIASNSNLF
     VINFFNPQEN EGGEGMQNMD NMDSGNSINS VNSANKVQKE ERADNMDNMA NALFNNFTLS
     LDKLNSTSYA IVINDASIKN IMRNAHAMKM FLSIAMRATV VLFCKMDNET KGKIIKKVLS
     LTTPRLTILG VGSTLNDAYL LKNTTISVCL SLNEQINVLY SISDYVLQEF RYIIDLLILG
     RLNKISLSRS FLWIIYLKIT IVSLYFFHNF DNFFSGSSTS SILYTQTTFA VFHYLLIIAF
     SAYEIDLPYK FIRRVPYIYQ FARRKYILNN TIIILTILEA MLISFISYYI MRVHVFPLIT
     HRTFTFHIFI LNFFITSEKI LLLSRTWHLY FFTLAILIIC FLFIYVNVYT LIDCLKIGKC
     ELSLFHTEDS YFWLSLLPIL YINFFIDKAA KFINNRIYPD IADYFRENIL KRDHKGSSKD
     STTEGNISAN VKDMTHGPLN IKGNVNLKKF IPTPKQYSIR DNNTYHSRTK KTKFIYETFR
     KVIGINIKYR NQQLNLEYKT YEKRNKLKLR TIGIVLFAIF FIMFFAQAVI SKCTNSIKFS
     LKTLTYFLIL YYFFATVWMV FIRLRNRSNS TLFFFIGKLV LIFGFIFELY ENVSNDIINM
     LVAYSFTVSY IFFLSFKILE GIIICTLVLV LTCWVYYEKN KTLGSMCAKF CEDPYLSLLH
     LQEVNISCLC KQQIVTFIIC MLSFSFICLS MKYYEIYYLK KKFLFRYKQK VNLTKQIEIL
     HTMLPSFLVE YLLISDPKAD GIMVGKNISG EDRGIISVIF CDIDDFQSMV STLQPHALVE
     TLDNLYLYFD KCIKYFNCIK IETVFESYLA ASGLSEKQND CVHKIKYDTR CAIKLAIAQL
     SAKYYISYKV LDRERNNVGS DNLRHSSSYT LPVLSGEDAH YDKYTQKNIS LRIGIHTGKA
     ISGVIGSVKP QYSLFGDTVN TASRMKSTAL TDHIHVSYDT YKYLEDDTSL VWKERKMFIK
     GKGEMRTYLL VDILDHVKKI EENSEVGLSS STLFGKTDDM VEGEHIDKGV VDGAHVDKDI
     VEGGTEKLHP KKKKKQKERR YREDPQQINA QSRLIEEILD VYERESDSSK KNNWYYYNKA
     DNASDSMKSN DIPTSSRIFN YRKSKYLSMD KLKLADTVRP NNLYDFESPV SLRKEIVGGK
     KESDEFFTSP YVEDKHQMEG IKKKRRSKAI LRKDSSDFMN QFDTPNGVLK KYIKERRNYQ
     RKFYAPHFYL GDLLKRSNEF KKGEKKKRAK KEKQGDRRKA THEEGVSYNF VNGSFSSNRE
     YSTESEFYLY DDKLRESKGY INFDDLFTKI YRKKRNILQG DIQHIPKQGF LFPRNIATKG
     KKKKKKKLRT KEELQQNDVH NGESKSGMRR QFFHHSKHKA ERKEEDIATK SCNDSSCEEV
     RNAFLRPRGR RRWEEGKLGR GYIHGAPLTR RARSCLLTMR DDPFFEVKKW KGIKNVKRKN
     LEQMDRMDRM SDGEQEEKDR TGWQKRKRSR GVASSGGDIT QNRQVQKRRH KFLREEVLLG
     IAMGSNVPPL EKEERTKRKK KKKKSSKNGT RVKQRRHQES HPTKLYENDL LKKKEVNFDR
     VEQASHKESS AVQIGSGVGE NAHKETLPGG RNHPTAESGK VEKSKLKKKK MVQKKISFYS
     LKDERSLSSG GPGGESSCAL KSNETNSGPN VEPQSSAKKE YFFTYSPAVK KKRGVLMKVN
     QAFRKYFKSM DMSERGIPAG HGRPEELTRG EASLPSRGPQ TSEELMKTSI TVSNKNVNFA
     HKFDNYNKNK LLKKLTSTLE GGKKKVSIFN RFYYKFNDEE LEEEYTRGYY REIINIDLTK
     KLIIIFIISE MIISLCNVIE LSYYNRKKVK DFVVIIWLIR CIYLFIITFI WLLLKIKLKE
     YKKNSSKMMW TVFILNIFLS SWCIIIMDLS CIHYSNIVGN SSTRSLFFMK DATELIVCMQ
     LIFIKNMLFK HKFFFFVFFF VFLIYSFSKL FEIHLCEIRI CSSILLILFI NILYFWYTEY
     LDRTQFLVKR KRNRMEKTSH DFLTRILPRQ VLEEYQNDNL QLTYSHEKIA FLFADIVGFT
     RWSKTVPPKD VLKLLQKLIS KIDKDTIKLG LYKLFTIGDA YVATSQPNSS ITDEREAVDG
     ILNIFKLAKL ILHNINTIKI QFNKHDFNMR IGLHYGSCVG GIIGSVRIRY DMWGLDVLIA
     NKIESNGIPG EIICSEHFKS FFLEHEPQA
//

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