(data stored in SCRATCH zone)

SWISSPROT: B4SJ43_STRM5

ID   B4SJ43_STRM5            Unreviewed;       312 AA.
AC   B4SJ43;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   08-MAY-2019, entry version 61.
DE   RecName: Full=dTDP-4-dehydrorhamnose reductase {ECO:0000256|RuleBase:RU364082};
DE            EC=1.1.1.133 {ECO:0000256|RuleBase:RU364082};
GN   OrderedLocusNames=Smal_0506 {ECO:0000313|EMBL:ACF50211.1};
OS   Stenotrophomonas maltophilia (strain R551-3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Stenotrophomonas;
OC   Stenotrophomonas maltophilia group.
OX   NCBI_TaxID=391008 {ECO:0000313|EMBL:ACF50211.1, ECO:0000313|Proteomes:UP000001867};
RN   [1] {ECO:0000313|EMBL:ACF50211.1, ECO:0000313|Proteomes:UP000001867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R551-3 {ECO:0000313|EMBL:ACF50211.1,
RC   ECO:0000313|Proteomes:UP000001867};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L.,
RA   Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Taghavi S., Monchy S., Newman L., Vangronsveld J.,
RA   van der Lelie D., Richardson P.;
RT   "Complete sequence of Stenotrophomonas maltophilia R551-3.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-
CC       hexulose to yield dTDP-L-rhamnose.
CC       {ECO:0000256|RuleBase:RU364082}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-
CC         rhamnose + H(+) + NADPH; Xref=Rhea:RHEA:21796,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57510, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:62830; EC=1.1.1.133;
CC         Evidence={ECO:0000256|RuleBase:RU364082};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU364082};
CC       Note=Binds 1 Mg(2+) ion per monomer.
CC       {ECO:0000256|RuleBase:RU364082};
CC   -!- PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.
CC       {ECO:0000256|RuleBase:RU364082}.
CC   -!- SIMILARITY: Belongs to the dTDP-4-dehydrorhamnose reductase
CC       family. {ECO:0000256|RuleBase:RU364082}.
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DR   EMBL; CP001111; ACF50211.1; -; Genomic_DNA.
DR   RefSeq; WP_012509983.1; NC_011071.1.
DR   STRING; 391008.Smal_0506; -.
DR   EnsemblBacteria; ACF50211; ACF50211; Smal_0506.
DR   KEGG; smt:Smal_0506; -.
DR   eggNOG; ENOG4105DBZ; Bacteria.
DR   eggNOG; COG1091; LUCA.
DR   HOGENOM; HOG000227712; -.
DR   KO; K00067; -.
DR   OMA; YHYSNEG; -.
DR   OrthoDB; 1076083at2; -.
DR   BioCyc; SMAL391008:SMAL_RS02590-MONOMER; -.
DR   UniPathway; UPA00124; -.
DR   Proteomes; UP000001867; Chromosome.
DR   GO; GO:0008831; F:dTDP-4-dehydrorhamnose reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019305; P:dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005913; dTDP_dehydrorham_reduct.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR029903; RmlD-like-bd.
DR   PANTHER; PTHR10491; PTHR10491; 1.
DR   Pfam; PF04321; RmlD_sub_bind; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01214; rmlD; 1.
PE   3: Inferred from homology;
DR   PRODOM; B4SJ43.
DR   SWISS-2DPAGE; B4SJ43.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001867};
KW   NADP {ECO:0000256|RuleBase:RU364082};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU364082,
KW   ECO:0000313|EMBL:ACF50211.1}.
FT   DOMAIN        1    296       RmlD_sub_bind. {ECO:0000259|Pfam:
FT                                PF04321}.
SQ   SEQUENCE   312 AA;  33291 MW;  D4F9C392449B88AE CRC64;
     MTVLVLGGNG QVGQELLRAL VPLGKVVTTT RSGILPDGSV CETADFDQPD SLPALLDRLQ
     PSVVVNAAAY TAVDRAEREV DAAFAVNAEA PGVIARWCAA HDVPFVHYST DYVFDGQGTA
     PYREDEPTAP LGVYGISKRD GEDAVRAAGG RHLIFRTAWV YASHGANFLR TMLRVGAERD
     ALRVVADQIG TPTPAALIAD VTAQALQHPG QLSGTWHLTA SGQTSWYGFA EAIFAEALAT
     GVLAKVPAVE AIPSSEYPTP AKRPAWSVLD NRKLQQDLGT ALPDWHEGLA IVMNEIKRLR
     DESAGGRASW TN
//

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