(data stored in SCRATCH zone)

SWISSPROT: B6H1P1_PENRW

ID   B6H1P1_PENRW            Unreviewed;       403 AA.
AC   B6H1P1;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 52.
DE   RecName: Full=Protein DOM34 homolog {ECO:0000256|RuleBase:RU362019};
DE            EC=3.1.-.- {ECO:0000256|RuleBase:RU362019};
GN   ORFNames=Pc13g01540 {ECO:0000313|EMBL:CAP91223.1}, PCH_Pc13g01540
GN   {ECO:0000313|EMBL:CAP91223.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91223.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP91223.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: May function in recognizing stalled ribosomes and
CC       triggering endonucleolytic cleavage of the mRNA, a mechanism to
CC       release non-functional ribosomes and degrade damaged mRNAs.
CC       {ECO:0000256|RuleBase:RU362019}.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|RuleBase:RU362019};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU362019}.
CC   -!- SIMILARITY: Belongs to the eukaryotic release factor 1 family.
CC       Pelota subfamily. {ECO:0000256|RuleBase:RU362019}.
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DR   EMBL; AM920428; CAP91223.1; -; Genomic_DNA.
DR   RefSeq; XP_002558599.1; XM_002558553.1.
DR   STRING; 500485.XP_002558599.1; -.
DR   EnsemblFungi; CAP91223; CAP91223; PCH_Pc13g01540.
DR   GeneID; 8307762; -.
DR   KEGG; pcs:Pc13g01540; -.
DR   eggNOG; KOG2869; Eukaryota.
DR   eggNOG; COG1537; LUCA.
DR   HOGENOM; HOG000184162; -.
DR   KO; K06965; -.
DR   OMA; SDNLFRC; -.
DR   OrthoDB; EOG092C2P04; -.
DR   BioCyc; PCHR:PC13G01540-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070966; P:nuclear-transcribed mRNA catabolic process, no-go decay; IEA:InterPro.
DR   GO; GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IEA:InterPro.
DR   GO; GO:0071025; P:RNA surveillance; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR005140; eRF1_1_Pelota.
DR   InterPro; IPR005141; eRF1_2.
DR   InterPro; IPR005142; eRF1_3.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004405; Transl-rel_pelota.
DR   PANTHER; PTHR10853; PTHR10853; 1.
DR   Pfam; PF03463; eRF1_1; 1.
DR   Pfam; PF03464; eRF1_2; 1.
DR   Pfam; PF03465; eRF1_3; 1.
DR   SMART; SM01194; eRF1_1; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   TIGRFAMs; TIGR00111; pelota; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6H1P1.
DR   SWISS-2DPAGE; B6H1P1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Cytoplasm {ECO:0000256|RuleBase:RU362019};
KW   Endonuclease {ECO:0000256|RuleBase:RU362019};
KW   Hydrolase {ECO:0000256|RuleBase:RU362019};
KW   Metal-binding {ECO:0000256|RuleBase:RU362019};
KW   Nuclease {ECO:0000256|RuleBase:RU362019};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   DOMAIN        1    138       eRF1_1. {ECO:0000259|SMART:SM01194}.
SQ   SEQUENCE   403 AA;  44294 MW;  6155AC5F23389C11 CRC64;
     MRCIKNKIEH NGSGAVTLCP EEPEDMWHAY NLIRPDDILR ASAIRRVTTV QDTGSTSSAR
     VHLNLVIRVK NLDFDPQSSQ LHVSGQIINE TPHTKIGQFH TLDLELNRNF TLEKEIGAGG
     EGVGWDSIAI ESLKDAVDEG GKRRAEAVAV VMQEGLAHIC FIGQFQTILK QKIEMSVPRK
     RQGGGDHDKG MNKFFKVTLE TLIRQMEFNT SLTSGANNEA VRPVLLASPG FVASGFQKYI
     QSEASTTTPG LKRLLPSLVV VHSASGYTNS LSEVLQSPAV KRLLADTKYA RETKLMDDFL
     EQLRKETNKA TYGPREVEDA VEQGAVGRGG GVLIVSNRLF RSQDVAERKR WVALVDRVRD
     VEGGDVRILS SDHESGKRLE GLGGIAALLT FPVIEPDLDS DAE
//

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