(data stored in SCRATCH zone)

SWISSPROT: B6H1P9_PENRW

ID   B6H1P9_PENRW            Unreviewed;       476 AA.
AC   B6H1P9;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 48.
DE   RecName: Full=Proline dehydrogenase {ECO:0000256|RuleBase:RU364054};
DE            EC=1.5.5.2 {ECO:0000256|RuleBase:RU364054};
GN   ORFNames=Pc13g01340 {ECO:0000313|EMBL:CAP91203.1}, PCH_Pc13g01340
GN   {ECO:0000313|EMBL:CAP91203.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91203.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP91203.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate.
CC       {ECO:0000256|RuleBase:RU364054}.
CC   -!- CATALYTIC ACTIVITY: L-proline + a quinone = (S)-1-pyrroline-5-
CC       carboxylate + a quinol. {ECO:0000256|RuleBase:RU364054}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|RuleBase:RU364054};
CC   -!- SIMILARITY: Belongs to the proline oxidase family.
CC       {ECO:0000256|RuleBase:RU364054}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AM920428; CAP91203.1; -; Genomic_DNA.
DR   RefSeq; XP_002558579.1; XM_002558533.1.
DR   ProteinModelPortal; B6H1P9; -.
DR   STRING; 500485.XP_002558579.1; -.
DR   EnsemblFungi; CAP91203; CAP91203; PCH_Pc13g01340.
DR   GeneID; 8305638; -.
DR   KEGG; pcs:Pc13g01340; -.
DR   eggNOG; KOG0186; Eukaryota.
DR   eggNOG; COG0506; LUCA.
DR   HOGENOM; HOG000178664; -.
DR   OMA; MGECLAY; -.
DR   OrthoDB; EOG092C1M0J; -.
DR   BioCyc; PCHR:PC13G01340-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0004657; F:proline dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006562; P:proline catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.220; -; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR002872; Proline_DH_dom.
DR   InterPro; IPR015659; Proline_oxidase.
DR   PANTHER; PTHR13914; PTHR13914; 1.
DR   Pfam; PF01619; Pro_dh; 1.
DR   SUPFAM; SSF51730; SSF51730; 2.
PE   3: Inferred from homology;
DR   PRODOM; B6H1P9.
DR   SWISS-2DPAGE; B6H1P9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   FAD {ECO:0000256|RuleBase:RU364054};
KW   Flavoprotein {ECO:0000256|RuleBase:RU364054};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU364054};
KW   Proline metabolism {ECO:0000256|RuleBase:RU364054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   DOMAIN      125    451       Pro_dh. {ECO:0000259|Pfam:PF01619}.
SQ   SEQUENCE   476 AA;  52366 MW;  964A490B6A43D62C CRC64;
     MGTLLPGKPL TALARCTRPT SNVNASMALR FTSTLQAHAQ AKTATSPSLP PLSVLPARVL
     LRSLLVSTIS SKRVLPIPAL SLMSFLSKPN RIWLFDVDRN PVLHGILKTT FYNQFCAGEN
     GAECRSTIRE MKDMGFRGMI LTYAAETVFD HSTQAQSGQG VAALKSENGD VAVEASVHCP
     SIEAWREGTV ETIYMTEAED YIAVKLTGAG AKVTEAFTAG ELPPHQMMDA LHEVCTKAKD
     RKVRILIDAE SQHFQKGISR VAVELMRKYN RDGYAAIYNT YQAYLKNTPA TLANHLALAN
     EDGFTLGLKL VRGAYMATDE RSLIHDTKED TDNAYNMIAQ GALRKNIGEF GDKGARDFPS
     VNLFLASHNK ESVVTAHELH KNRVMSGLPT VPVRFAQLHG MSDEVSFSLL QMNDGDGTPE
     VYKCSTWGGM GECLAYLLRR AIENRDAVLR TDNEYRALKK EVFRRVKSVL SLSPSS
//

If you have problems or comments...

PBIL Back to PBIL home page