(data stored in SCRATCH zone)

SWISSPROT: B6H1V8_PENRW

ID   B6H1V8_PENRW            Unreviewed;       501 AA.
AC   B6H1V8;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 48.
DE   RecName: Full=DNA primase large subunit {ECO:0000256|PIRNR:PIRNR009449};
DE            EC=2.7.7.- {ECO:0000256|PIRNR:PIRNR009449};
GN   ORFNames=Pc13g03210 {ECO:0000313|EMBL:CAP91390.1}, PCH_Pc13g03210
GN   {ECO:0000313|EMBL:CAP91390.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91390.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP91390.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: DNA primase is the polymerase that synthesizes small RNA
CC       primers for the Okazaki fragments made during discontinuous DNA
CC       replication. {ECO:0000256|PIRNR:PIRNR009449}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|PIRNR:PIRNR009449};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000256|PIRNR:PIRNR009449};
CC   -!- SIMILARITY: Belongs to the eukaryotic-type primase large subunit
CC       family. {ECO:0000256|PIRNR:PIRNR009449}.
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DR   EMBL; AM920428; CAP91390.1; -; Genomic_DNA.
DR   RefSeq; XP_002558759.1; XM_002558713.1.
DR   STRING; 500485.XP_002558759.1; -.
DR   EnsemblFungi; CAP91390; CAP91390; PCH_Pc13g03210.
DR   GeneID; 8313421; -.
DR   KEGG; pcs:Pc13g03210; -.
DR   eggNOG; KOG2267; Eukaryota.
DR   eggNOG; COG2219; LUCA.
DR   HOGENOM; HOG000212154; -.
DR   KO; K02685; -.
DR   OMA; DCHGCPY; -.
DR   OrthoDB; EOG092C27SX; -.
DR   BioCyc; PCHR:PC13G03210-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003896; F:DNA primase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   CDD; cd07322; PriL_PriS_Eukaryotic; 1.
DR   InterPro; IPR016558; DNA_primase_lsu_euk.
DR   InterPro; IPR007238; DNA_primase_lsu_euk/arc.
DR   Pfam; PF04104; DNA_primase_lrg; 1.
DR   PIRSF; PIRSF009449; DNA_primase_large_subunit; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6H1V8.
DR   SWISS-2DPAGE; B6H1V8.
KW   4Fe-4S {ECO:0000256|PIRNR:PIRNR009449, ECO:0000256|PIRSR:PIRSR009449-
KW   1}; Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   DNA replication {ECO:0000256|PIRNR:PIRNR009449};
KW   DNA-binding {ECO:0000256|PIRNR:PIRNR009449};
KW   DNA-directed RNA polymerase {ECO:0000256|PIRNR:PIRNR009449};
KW   Iron {ECO:0000256|PIRNR:PIRNR009449, ECO:0000256|PIRSR:PIRSR009449-1};
KW   Iron-sulfur {ECO:0000256|PIRNR:PIRNR009449,
KW   ECO:0000256|PIRSR:PIRSR009449-1};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR009449,
KW   ECO:0000256|PIRSR:PIRSR009449-1};
KW   Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR009449};
KW   Primosome {ECO:0000256|PIRNR:PIRNR009449};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW   Transcription {ECO:0000256|PIRNR:PIRNR009449};
KW   Transferase {ECO:0000256|PIRNR:PIRNR009449}.
FT   METAL       308    308       Iron-sulfur (4Fe-4S). {ECO:0000256|PIRSR:
FT                                PIRSR009449-1}.
FT   METAL       391    391       Iron-sulfur (4Fe-4S). {ECO:0000256|PIRSR:
FT                                PIRSR009449-1}.
FT   METAL       408    408       Iron-sulfur (4Fe-4S). {ECO:0000256|PIRSR:
FT                                PIRSR009449-1}.
FT   METAL       449    449       Iron-sulfur (4Fe-4S). {ECO:0000256|PIRSR:
FT                                PIRSR009449-1}.
SQ   SEQUENCE   501 AA;  57871 MW;  444B0025B9FD69D2 CRC64;
     MIRQDAHRID PKRRAVIDPK KRQFATPTYK QQDYAHRLNI YEIPPTAEIT LEQFEQWAID
     RLKILAEIEA CSYRNKSPAE TESYITPLLQ KFLPLSSNTS SPSGAADPRL KNERQKDHYS
     HFILRLAFSA TEDLRRRFAR AETMLFKFRF QKDDTREKRA FIDSLNLDWE PVGDFEKTEI
     AKNLLSSTPG LRGLEDETWY KVDWEKVPEL VERRSIFLKK GKAYVPGREQ LSMIVAEFTA
     RLERALELTS RALPRLDEDD RLTPILNHLS KNFGSAESVY SEGEGYVDGS PITASSIDQL
     AQQHFPLCMK SLHVNLRKNN HLKHFGRLQY TLFLKGIGLS LEECILFWRQ SFKGKTDDEF
     NSQYKYNIRH AYGEVGGDVN RRGKGYTPYS CQKILGDSNP GIGQTHGCPY RHYSVDNLVG
     FLQATGVSDK EVLRGVREDV GKMRYHIACN RVFEATHKNE IKKVKEDGSW SQTDLDTIVH
     PNTYFKRSYL LKQMSKAPKD A
//

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