(data stored in SCRATCH zone)

SWISSPROT: LCL3_PENRW

ID   LCL3_PENRW              Reviewed;         292 AA.
AC   B6H1W0;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   10-APR-2019, entry version 53.
DE   RecName: Full=Probable endonuclease lcl3;
DE            EC=3.1.-.-;
GN   Name=lcl3; ORFNames=Pc13g03230;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion. Membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LCL3 family. {ECO:0000305}.
DR   EMBL; AM920428; CAP91392.1; -; Genomic_DNA.
DR   RefSeq; XP_002558761.1; XM_002558715.1.
DR   SMR; B6H1W0; -.
DR   EnsemblFungi; CAP91392; CAP91392; PCH_Pc13g03230.
DR   GeneID; 8313423; -.
DR   KEGG; pcs:Pc13g03230; -.
DR   eggNOG; ENOG410IJ6S; Eukaryota.
DR   eggNOG; COG1525; LUCA.
DR   HOGENOM; HOG000212133; -.
DR   OMA; DNFHLFH; -.
DR   OrthoDB; 1333771at2759; -.
DR   BioCyc; PCHR:PC13G03230-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.90; -; 1.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR   Pfam; PF00565; SNase; 1.
DR   SMART; SM00318; SNc; 1.
DR   PROSITE; PS50830; TNASE_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6H1W0.
DR   SWISS-2DPAGE; B6H1W0.
KW   Calcium; Complete proteome; Endonuclease; Hydrolase; Membrane;
KW   Metal-binding; Mitochondrion; Nuclease; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    292       Probable endonuclease lcl3.
FT                                /FTId=PRO_0000408673.
FT   TRANSMEM     45     61       Helical. {ECO:0000255}.
FT   DOMAIN       83    250       TNase-like. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00272}.
FT   ACT_SITE    134    134       {ECO:0000255|PROSITE-ProRule:PRU00272}.
FT   ACT_SITE    142    142       {ECO:0000255|PROSITE-ProRule:PRU00272}.
FT   ACT_SITE    182    182       {ECO:0000255|PROSITE-ProRule:PRU00272}.
FT   METAL       139    139       Calcium. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00272}.
SQ   SEQUENCE   292 AA;  33637 MW;  4D0B9F6EDABE1D00 CRC64;
     MRWPPWSSES TNDEQKQTPS SWLSSAANKP SSILDWTAFT ELRTIIPTVV LTSGILIAVR
     FHRRYLRRIP DAPSISSSYL RRRSIFGQVT SVGDGDNFRI FHTPGGRMAG WGWLPWKKVP
     TVKKDLKDKT IHIRLAGVDA PELAHFGRPE QPFARDAHTW LTSYLSNRRV RALVHRQDQY
     SRVVASVFVR RAFDFPPFRR RDVSYEMLKR GLATVYEAKI GSEFGGDKME KKYRKAEWWA
     KKRARGLWKD YRRVGSGWES PREYKNRMGM GDPLPIEKGN GKGNGKGKIG QK
//

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