(data stored in SCRATCH zone)

SWISSPROT: B6H269_PENRW

ID   B6H269_PENRW            Unreviewed;       644 AA.
AC   B6H269;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 54.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00900};
DE            EC=2.1.1.43 {ECO:0000256|PROSITE-ProRule:PRU00900};
GN   ORFNames=Pc13g04130 {ECO:0000313|EMBL:CAP91482.1}, PCH_Pc13g04130
GN   {ECO:0000313|EMBL:CAP91482.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91482.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP91482.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|PROSITE-ProRule:PRU00900}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. Suvar4-20 subfamily. {ECO:0000256|PROSITE-
CC       ProRule:PRU00900}.
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DR   EMBL; AM920428; CAP91482.1; -; Genomic_DNA.
DR   RefSeq; XP_002558849.1; XM_002558803.1.
DR   STRING; 500485.XP_002558849.1; -.
DR   EnsemblFungi; CAP91482; CAP91482; PCH_Pc13g04130.
DR   GeneID; 8304058; -.
DR   KEGG; pcs:Pc13g04130; -.
DR   eggNOG; KOG2589; Eukaryota.
DR   eggNOG; ENOG410XPH8; LUCA.
DR   HOGENOM; HOG000214006; -.
DR   KO; K11429; -.
DR   OMA; FMGPARF; -.
DR   OrthoDB; EOG092C4LF0; -.
DR   BioCyc; PCHR:PC13G04130-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:UniProtKB-UniRule.
DR   InterPro; IPR025783; Hist-Lys_N-MeTrfase_SET9.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51567; SAM_MT43_SUVAR420_1; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6H269.
DR   SWISS-2DPAGE; B6H269.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00900};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU00900};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU00900}.
FT   DOMAIN      121    235       SET. {ECO:0000259|PROSITE:PS50280}.
SQ   SEQUENCE   644 AA;  72931 MW;  4639C7FF1663B11C CRC64;
     MPPKRARKSS PAAERRERLT LAKLASYDDV ATDALVDHAY FWTTTRKNRT KYSPARGIHD
     DDVGRILLED VIVDKDIPKA ERKLLELPGL KKYMTNLRSP REKEWFRRHL RKYIQMYLPD
     CPFEVTTTNR YIITQHEAAI CARRFIKKGE EIKHLSGTLV SMTHEEELDL GLTRKDFSIV
     MSSRRRAPSF FLGPARFANH DCDANGSLTT RGNEGMSVLA MRDIHEGEEI TVSYGEDYFG
     IDNCECLCHT CEIAVRNGWS SHVDTETNSK ESSPASEVTA TEDTPAENSN VSRKRRRSSD
     MEEPDSSSTL SCSTPRKRAK FQRQVSKLRE EISVSELTGE SGSAPPRGSD STPIQDTVLI
     SNALLAETAP QVVARRGDLN GTNGTNSTIP TDCESLSSTA DQSHRSSTST TPTTEDDIEP
     QIKTEDTTLQ PSESKALNGK DHPDASPEGQ HITTHPMDID PEEGLSDLSN STKLDDDKVV
     DKPKKRKPRT KRRFIVDSVE TESQVARFPG DYTKTPRLLA QKYDRWVECQ TCDTWFLQSN
     SYLTRRECPR CERHSKLYGF QWPSTDKGPD GEERVMDHRT IHRFLSPDAQ SRICRRDRGV
     SFGITPTPEL SDTNTPETET SDVTESRRDA RATRRRTREL RMTM
//

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