(data stored in SCRATCH zone)

SWISSPROT: B6H2A3_PENRW

ID   B6H2A3_PENRW            Unreviewed;       602 AA.
AC   B6H2A3;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   05-JUL-2017, entry version 60.
DE   RecName: Full=Malic enzyme {ECO:0000256|RuleBase:RU003426};
GN   ORFNames=Pc13g04510 {ECO:0000313|EMBL:CAP91520.1}, PCH_Pc13g04510
GN   {ECO:0000313|EMBL:CAP91520.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91520.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP91520.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|RuleBase:RU003426}.
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DR   EMBL; AM920428; CAP91520.1; -; Genomic_DNA.
DR   RefSeq; XP_002558886.1; XM_002558840.1.
DR   ProteinModelPortal; B6H2A3; -.
DR   STRING; 500485.XP_002558886.1; -.
DR   EnsemblFungi; CAP91520; CAP91520; PCH_Pc13g04510.
DR   GeneID; 8312322; -.
DR   KEGG; pcs:Pc13g04510; -.
DR   eggNOG; KOG1257; Eukaryota.
DR   eggNOG; COG0281; LUCA.
DR   HOGENOM; HOG000042486; -.
DR   KO; K00029; -.
DR   OMA; FRYPEPE; -.
DR   OrthoDB; EOG092C16UJ; -.
DR   BioCyc; PCHR:PC13G04510-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR015884; Malic_enzyme_CS.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00331; MALIC_ENZYMES; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6H2A3.
DR   SWISS-2DPAGE; B6H2A3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3,
KW   ECO:0000256|RuleBase:RU003426};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003426};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   DOMAIN       86    264       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      274    534       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE    109    109       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE    180    180       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       251    251       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       252    252       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       273    273       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   602 AA;  66792 MW;  744205E3A5891971 CRC64;
     MARYPLLPTQ QNRTVHATPA PFVNHTSPAD ANYDTANPSY IRKYLRTYGL TPPRAEGYET
     QKARCLAQLG LKSTPIEKFL YLSTLRKNNV HLFYRLVTDH LRELTPLIYT PVVGEACQKW
     SEIYQQPEGM YLSWEDRGNL ASVIANWPES NVEITCITDG SRILGLGDLG INGMGIPIGK
     LALYTACAGI RPEATLPLTL DLGTGNKALR EDPLYMGSRR DKVSPEEERE FLDELMAALT
     ERWPGIVIQF EDFKNPFPAL ERYRDMYTCF NDDIQGTGAV ILGGVINAVK RSGLPCKDHR
     AVFFGAGSAG VGVARQIVEF FMREGMTEDE ARNCFYLVDT KGLVTADRGD KLADHKVYFA
     RRDNNGEQYK TLDEVVDHVK PSILMGLSTM GGVFTPEILR KMADWNTAPL IFPLSNPSSK
     SECDFETAIA NTDGRCLFAS GSPFPNCTFT NSAGETRTYY PGQGNNMYVF PGIGLGSILS
     KAVRVTDSMI YASGEALSAA LNGEELERGL LYPDITRIRE VSVVVTRKVM RAAQEDKVDR
     EIALRSLSDV ELDNWIKARM YDPHTEVRAL EREVGHLLSS LGTISPPMTA SGSPTEEKNA
     KL
//

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