(data stored in SCRATCH zone)

SWISSPROT: B6H2B3_PENRW

ID   B6H2B3_PENRW            Unreviewed;       118 AA.
AC   B6H2B3;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 44.
DE   RecName: Full=Tubulin-specific chaperone A {ECO:0000256|RuleBase:RU364030};
GN   ORFNames=Pc13g04590 {ECO:0000313|EMBL:CAP91528.1}, PCH_Pc13g04590
GN   {ECO:0000313|EMBL:CAP91528.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91528.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP91528.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- SUBUNIT: Supercomplex made of cofactors A to E. Cofactors A and D
CC       function by capturing and stabilizing tubulin in a quasi-native
CC       conformation. Cofactor E binds to the cofactor D-tubulin complex;
CC       interaction with cofactor C then causes the release of tubulin
CC       polypeptides that are committed to the native state.
CC       {ECO:0000256|RuleBase:RU364030}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|RuleBase:RU364030}.
CC   -!- SIMILARITY: Belongs to the TBCA family.
CC       {ECO:0000256|RuleBase:RU364030}.
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DR   EMBL; AM920428; CAP91528.1; -; Genomic_DNA.
DR   RefSeq; XP_002558894.1; XM_002558848.1.
DR   EnsemblFungi; CAP91528; CAP91528; PCH_Pc13g04590.
DR   GeneID; 8312330; -.
DR   KEGG; pcs:Pc13g04590; -.
DR   eggNOG; ENOG410J2TV; Eukaryota.
DR   eggNOG; ENOG41122E4; LUCA.
DR   HOGENOM; HOG000213817; -.
DR   KO; K17292; -.
DR   OMA; DENREYM; -.
DR   OrthoDB; EOG092C5U07; -.
DR   BioCyc; PCHR:PC13G04590-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0048487; F:beta-tubulin binding; IEA:InterPro.
DR   GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:UniProtKB-UniRule.
DR   GO; GO:0007021; P:tubulin complex assembly; IEA:UniProtKB-UniRule.
DR   InterPro; IPR004226; TBCA.
DR   PANTHER; PTHR21500; PTHR21500; 1.
DR   Pfam; PF02970; TBCA; 1.
DR   ProDom; PD010430; CofA_tubulin_bd; 1.
DR   SUPFAM; SSF46988; SSF46988; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6H2B3.
DR   SWISS-2DPAGE; B6H2B3.
KW   Chaperone {ECO:0000256|RuleBase:RU364030};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Cytoplasm {ECO:0000256|RuleBase:RU364030};
KW   Cytoskeleton {ECO:0000256|RuleBase:RU364030};
KW   Microtubule {ECO:0000256|RuleBase:RU364030};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
SQ   SEQUENCE   118 AA;  13302 MW;  930B0E41DB25C129 CRC64;
     MAPRTQLEIT TSSVIRLVKE EASYHNELQQ QAERIKKLEA DTTDGDENRE YTLKQEHMSL
     EETKKVLPTL KEKIVQTVAN LEALIIEEGK KGSESNVEHI TAAKEAIAQA KTAQREIS
//

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