(data stored in SCRATCH zone)

SWISSPROT: STUA_PENRW

ID   STUA_PENRW              Reviewed;         818 AA.
AC   B6H2G9;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 50.
DE   RecName: Full=Cell pattern formation-associated protein stuA {ECO:0000305};
DE   AltName: Full=Stunted protein A {ECO:0000250|UniProtKB:P36011};
GN   Name=stuA {ECO:0000303|PubMed:21148688}; ORFNames=Pc13g04920;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=21148688; DOI=10.1128/AEM.01557-10;
RA   Sigl C., Haas H., Specht T., Pfaller K., Kuernsteiner H., Zadra I.;
RT   "Among developmental regulators, StuA but not BrlA is essential for
RT   penicillin V production in Penicillium chrysogenum.";
RL   Appl. Environ. Microbiol. 77:972-982(2011).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=11810244; DOI=10.1007/s00438-001-0591-z;
RA   Banuelos O., Casqueiro J., Steidl S., Gutierrez S., Brakhage A.,
RA   Martin J.F.;
RT   "Subcellular localization of the homocitrate synthase in Penicillium
RT   chrysogenum.";
RL   Mol. Genet. Genomics 266:711-719(2002).
CC   -!- FUNCTION: Transcription factor that regulates asexual reproduction
CC       (PubMed:21148688). Binds the StuA-response elements (StRE) with
CC       the consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters
CC       of target genes (By similarity). Controls the expression of the
CC       penicillin gene cluster (PubMed:21148688).
CC       {ECO:0000250|UniProtKB:P36011, ECO:0000269|PubMed:21148688}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11810244}.
CC   -!- DISRUPTION PHENOTYPE: Blocks conidiation and causes aberrant
CC       hyphal morphology (PubMed:21148688). Decreases expression of
CC       developmental regulators brlA and abaA (PubMed:21148688).
CC       {ECO:0000269|PubMed:21148688}.
CC   -!- SIMILARITY: Belongs to the EFG1/PHD1/stuA family. {ECO:0000305}.
DR   EMBL; AM920428; CAP91561.1; -; Genomic_DNA.
DR   RefSeq; XP_002558927.1; XM_002558881.1.
DR   SMR; B6H2G9; -.
DR   STRING; 500485.XP_002558927.1; -.
DR   EnsemblFungi; CAP91561; CAP91561; PCH_Pc13g04920.
DR   GeneID; 8312363; -.
DR   KEGG; pcs:Pc13g04920; -.
DR   eggNOG; ENOG410IG5V; Eukaryota.
DR   eggNOG; ENOG410XQ28; LUCA.
DR   HOGENOM; HOG000213682; -.
DR   KO; K12763; -.
DR   OMA; LLYHPTN; -.
DR   OrthoDB; EOG092C2R9Z; -.
DR   BioCyc; PCHR:PC13G04920-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.260.10; -; 1.
DR   InterPro; IPR018004; KilA_N/APSES_HTH.
DR   InterPro; IPR003163; Tscrpt_reg_HTH_APSES-type.
DR   SMART; SM01252; KilA-N; 1.
DR   SUPFAM; SSF54616; SSF54616; 1.
DR   PROSITE; PS51299; HTH_APSES; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6H2G9.
DR   SWISS-2DPAGE; B6H2G9.
KW   Complete proteome; Conidiation; DNA-binding; Nucleus;
KW   Reference proteome; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    818       Cell pattern formation-associated protein
FT                                stuA.
FT                                /FTId=PRO_0000435981.
FT   DOMAIN      320    426       HTH APSES-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00630}.
FT   DNA_BIND    354    375       H-T-H motif. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00630}.
FT   REGION      765    788       Nuclear localization domain.
FT                                {ECO:0000250|UniProtKB:P36011}.
SQ   SEQUENCE   818 AA;  87533 MW;  793FB1910A4FD45A CRC64;
     MCSTIVNDLD DYCASLNSSF SKSLYCASHD GRHLRRPLLA SSLYSKPFIR ATEKLELPSI
     SQVHTRGPAD IPWYNPHAAE RPLLPGDKLP ALSLPTATQG LSRTAYPDPS VTNSTNSSAR
     TSLSSASVPV NEPRSPPSSA DLSGTQGRLS LDSSAPTEYS LPPSVNEGYY PSPTSLGSMN
     QTQPYMDVHS HMSSAQSYAP QGATAGAMSQ YQYHGQPPVM QPASSYAPAA YPQYGYPTGV
     TSPPTGHPPS SMGGQMPAQL LPLPGKLQSQ NVIEDYSDRY QVSNHAVAPP SGYGNSTGAP
     LQGFVFDGTG QVAPPGAKPR VTATLWEDEG SLCYQVEAKG VCVARREDNH MINGTKLLNV
     AGMTRGRRDG ILKSEKLRHV VKIGPMHLKG VWIPFERALE FANKEKITDL LYPLFVHNIG
     GLLYHPANQT RTNMVVQESQ QRRLEGPPPG PQRTPSGSQQ GPIHHHHPSL QTPMSSHMSQ
     GPMNGQPGSR PGLERANTFP TPPASASSMM NQGSSYEWGG QVPHTQPLSI DTTLSNQRSM
     PTTPATTPPG NNMQGLPAYQ GQGYDSSKPY YSAAPQTHAQ YAPHTPLTQS GMSSYGQPLA
     GGYMKSEMAP PNPRPGVSEP ETSERDSNRY SQSNGPGETV AEHDQEYMQD HNAGYNSNRG
     SYTYTTNPSV SSLTGEHSQL TPEMTSSPSQ QNGSGRMTPR TGAGPPPHWA SGYNTPPRPA
     ATTLYNAVSD TRGTPANGAS DPYSMASTTA PVYPTGNGSL SAGSKRMRED DDIRAESTAE
     YETSKRRKTI TDATLGGPVG GPPILQPMKP SGVMARHR
//

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