(data stored in SCRATCH zone)

SWISSPROT: VPS10_PENRW

ID   VPS10_PENRW             Reviewed;        1489 AA.
AC   B6H711;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   10-MAY-2017, entry version 44.
DE   RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE   AltName: Full=Carboxypeptidase Y receptor;
DE            Short=CPY receptor;
DE   AltName: Full=Sortilin vps10;
DE   AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE   Flags: Precursor;
GN   Name=vps10; ORFNames=Pc16g01030;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC       required for the intracellular sorting and delivery of soluble
CC       vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.
CC       Executes multiple rounds of sorting by cycling between the late
CC       Golgi and a prevacuolar endosome-like compartment (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC       membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC       Prevacuolar compartment membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Note=Cycles between the Golgi
CC       apparatus and the prevacuolar compartment. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC       {ECO:0000305}.
DR   EMBL; AM920431; CAP92773.1; -; Genomic_DNA.
DR   RefSeq; XP_002560521.1; XM_002560475.1.
DR   SMR; B6H711; -.
DR   STRING; 500485.XP_002560521.1; -.
DR   EnsemblFungi; CAP92773; CAP92773; PCH_Pc16g01030.
DR   GeneID; 8315370; -.
DR   KEGG; pcs:Pc16g01030; -.
DR   eggNOG; KOG3511; Eukaryota.
DR   eggNOG; ENOG410Y3W5; LUCA.
DR   HOGENOM; HOG000169063; -.
DR   OMA; KDAHLWE; -.
DR   OrthoDB; EOG092C0D5Y; -.
DR   BioCyc; PCHR:PC16G01030-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c16.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   Pfam; PF15902; Sortilin-Vps10; 2.
DR   Pfam; PF15901; Sortilin_C; 2.
DR   SMART; SM00602; VPS10; 2.
PE   3: Inferred from homology;
DR   PRODOM; B6H711.
DR   SWISS-2DPAGE; B6H711.
KW   Complete proteome; Glycoprotein; Golgi apparatus; Membrane;
KW   Protein transport; Receptor; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24   1489       Vacuolar protein sorting/targeting
FT                                protein 10.
FT                                /FTId=PRO_5000409175.
FT   TOPO_DOM     24   1362       Lumenal. {ECO:0000255}.
FT   TRANSMEM   1363   1383       Helical. {ECO:0000255}.
FT   TOPO_DOM   1384   1410       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM   1411   1431       Helical. {ECO:0000255}.
FT   TOPO_DOM   1432   1489       Lumenal. {ECO:0000255}.
FT   REPEAT       63     72       BNR 1.
FT   REPEAT      387    396       BNR 2.
FT   REPEAT      454    464       BNR 3.
FT   REPEAT      495    505       BNR 4.
FT   REPEAT      738    747       BNR 5.
FT   REPEAT     1118   1128       BNR 6.
FT   REPEAT     1160   1169       BNR 7.
FT   CARBOHYD    306    306       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    331    331       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    684    684       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    862    862       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    925    925       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    982    982       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1272   1272       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   1489 AA;  167525 MW;  50B065ABEBCB4993 CRC64;
     MIPRWLLLTL SLLLVWASHP AAAKGNEPNI VTHELDAPPA DLFYFHGTNT ILYRDRRSLT
     AHVSFDGGEE WETVKGNDGT IEGTVDLIWR HPFDDNRAYI LGENGKHWIT TDQAKSWRPF
     QVDVLPFASM RSFPLEFNGW DPKKVIFMGL DCTILGCLPQ TFYTTDDFET VKPLREMTLQ
     CMWAASRPQF ALDIDMPKST GDRILCVVPG LKGPFEHTRT ERLIYSDSFF KDDAEGTEAK
     LDHGKPLSGV SLQIRSVSKY IVARLQSRGT QEQALYVSDD SNVWHRAEFG KHRIEEDAYT
     ILESTNYSIQ IDVQTTWQDN RMGSLFSSNS NGTYFTQNIE HTNEDLNGLV DFERVTGIHG
     ITIVNTVKNW EEAKKSDSNK KKLISSISFD DGRTFQPLKA DKDELHLHSM TTYAALHEMP
     LPDHRMFSSP APGLVMGVGN TGGHLEDYSK GDLYVSDNAG LTWRRALKGP HRYEFGDQGG
     VITAVLDSSQ TDKVQFSIDH GKEWESISLG QKIRPLFLVS TPDSTSLKFL LVGTSSDDTT
     KTLMFFIDFD GLHERECGSG DLEEWTARLN EKGEPDCLMG QKQFFQRRKA NADCFIKKEF
     AISGPEFQLC KCSAEDFECD YNFVRSEDRK ECVPAVPLTP PAGKCKDPSD KYMGPSGWRL
     IPGNACIREG GEDLEREIER SCSNVTGPPL ITDGKPRAGK PQTISAKWTN YFYLERQASN
     NGVDETIMML TDKYELHVSR DHGRNWKQIH PDEKFIEMVQ HPYFSDTAFF LTDGKRVYYT
     INHGDSFHFF DAPSVPNKEY IRKLAFHEKF QDSLIWIGHK DCEGKNCRSQ AYVTDKRGAS
     WEPMLIGIAD GGCNFGYQEG RNNSEKLVIC EQYKDEEKNN NRQLVISDDY FSTMEVKFEN
     IARSATKNGF EVVAWYEGDQ KEYLNASVSV DGRTYANAHF PFNIKVPQYT VLPSSPHALF
     LLVMVNGGGE RSFGSLVKSN SNGTYFVQSL EGLNVNDRGY TDYDELQGLE GVAIANVVSN
     REEVLNKGAA KKLRTMITHN DGGQWMLLAP PSKDVDGKNF DCSVTEGKGT EKCALHFHGY
     TERRDYRDTL YSGSAIGLML ALGNVGEHLT SASEADTYLT RDGGISWTQV KKGQYMWEFG
     AAGSVIVLVS DRKATKVVHY TLDEGMSWHE FQFAEKELVI DDISTVPSDT SKKFLLWGID
     GGKRVIVTLD FSGIWSRDCN DDESDYYNWA PTHPFQEENC IFGHVEEYHR KKPAAECWNA
     WREPHIHSIG RNCTCTRADF ECDYNYEIQT DGSCGLVPGL QPQDHVAQCS QDPDKVEYWE
     PTGYRRIPQT TCEGGLLLDQ DVSKPCPNKE EEYQKKHGIS GTGLFFAIVT PIAVAVAVGW
     YAYTHWDGKF GQIRLGDSGG SQSWLSRDSM LVAVPVALIA GIVAVAQSLP LLVKSLARSS
     SGLFGRRGMQ RPYATRGSFA ARRGDYSSVV DDEDELLGAD DFDDEEDQA
//

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