(data stored in SCRATCH zone)

SWISSPROT: B6H714_PENRW

ID   B6H714_PENRW            Unreviewed;       243 AA.
AC   B6H714;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 48.
DE   RecName: Full=Ubiquitin carboxyl-terminal hydrolase {ECO:0000256|RuleBase:RU361215};
DE            EC=3.4.19.12 {ECO:0000256|RuleBase:RU361215};
GN   ORFNames=Pc16g01050 {ECO:0000313|EMBL:CAP92775.1}, PCH_Pc16g01050
GN   {ECO:0000313|EMBL:CAP92775.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP92775.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP92775.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester,
CC       thioester, amide, peptide and isopeptide bonds formed by the C-
CC       terminal Gly of ubiquitin (a 76-residue protein attached to
CC       proteins as an intracellular targeting signal).
CC       {ECO:0000256|RuleBase:RU361215}.
CC   -!- SIMILARITY: Belongs to the peptidase C12 family.
CC       {ECO:0000256|RuleBase:RU361215}.
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DR   EMBL; AM920431; CAP92775.1; -; Genomic_DNA.
DR   RefSeq; XP_002560523.1; XM_002560477.1.
DR   STRING; 500485.XP_002560523.1; -.
DR   EnsemblFungi; CAP92775; CAP92775; PCH_Pc16g01050.
DR   GeneID; 8315372; -.
DR   KEGG; pcs:Pc16g01050; -.
DR   eggNOG; KOG1415; Eukaryota.
DR   eggNOG; ENOG4111HNA; LUCA.
DR   HOGENOM; HOG000182400; -.
DR   KO; K05609; -.
DR   OMA; FISFVKG; -.
DR   OrthoDB; EOG092C4ZXA; -.
DR   BioCyc; PCHR:PC16G01050-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c16.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.532.10; -; 1.
DR   InterPro; IPR001578; Peptidase_C12_UCH.
DR   PANTHER; PTHR10589; PTHR10589; 1.
DR   Pfam; PF01088; Peptidase_C12; 1.
DR   PRINTS; PR00707; UBCTHYDRLASE.
PE   3: Inferred from homology;
DR   PRODOM; B6H714.
DR   SWISS-2DPAGE; B6H714.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Hydrolase {ECO:0000256|RuleBase:RU361215};
KW   Protease {ECO:0000256|RuleBase:RU361215};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW   Thiol protease {ECO:0000256|RuleBase:RU361215};
KW   Ubl conjugation pathway {ECO:0000256|RuleBase:RU361215}.
FT   DOMAIN       15    207       UCH_1. {ECO:0000259|Pfam:PF01088}.
SQ   SEQUENCE   243 AA;  26697 MW;  2F9814A74E3912EC CRC64;
     MFNLGVQVIN GQKTFIPLEN NPEVHTHLCK NLGVSPSLTF HDILSTTPEM LSWIPRPVNA
     LILLCDKPIY LAARSRVEHS IPEYLGSGAD EPVLWMKQTI GHACGLMALL HVVTNLENGK
     YVLAGSELEK IVKRAVGLGP VERARLLYDS RFLEEAHMDA ASEGSSIVPL PQEECGFHFI
     AFVKKDGKVW ELNGGMNGPL LRGELEGDLL GEEGLDMTVR EFLSAADTEV HRGMSIIAVN
     NTM
//

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