(data stored in SCRATCH zone)

SWISSPROT: B6H8Z9_PENRW

ID   B6H8Z9_PENRW            Unreviewed;      6064 AA.
AC   B6H8Z9;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   30-AUG-2017, entry version 57.
DE   SubName: Full=Pc16g04690 protein {ECO:0000313|EMBL:CAP93139.1};
GN   ORFNames=Pc16g04690 {ECO:0000313|EMBL:CAP93139.1}, PCH_Pc16g04690
GN   {ECO:0000313|EMBL:CAP93139.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP93139.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP93139.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00258}.
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DR   EMBL; AM920431; CAP93139.1; -; Genomic_DNA.
DR   RefSeq; XP_002560820.1; XM_002560774.1.
DR   ProteinModelPortal; B6H8Z9; -.
DR   STRING; 500485.XP_002560820.1; -.
DR   EnsemblFungi; CAP93139; CAP93139; PCH_Pc16g04690.
DR   GeneID; 8304562; -.
DR   KEGG; pcs:Pc16g04690; -.
DR   eggNOG; ENOG410IQQ3; Eukaryota.
DR   eggNOG; KOG1178; Eukaryota.
DR   eggNOG; COG1020; LUCA.
DR   HOGENOM; HOG000207851; -.
DR   OMA; DIVSWRI; -.
DR   OrthoDB; EOG092C000U; -.
DR   BioCyc; PCHR:PC16G04690-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c16.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 4.
DR   Pfam; PF00668; Condensation; 7.
DR   Pfam; PF00550; PP-binding; 4.
DR   SMART; SM00823; PKS_PP; 3.
DR   SUPFAM; SSF47336; SSF47336; 5.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 3.
DR   PROSITE; PS50075; ACP_DOMAIN; 5.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   4: Predicted;
DR   PRODOM; B6H8Z9.
DR   SWISS-2DPAGE; B6H8Z9.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   DOMAIN      786    854       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     3139   3207       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     4241   4309       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     5337   5405       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     5927   6010       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   COILED     1745   1768       {ECO:0000256|SAM:Coils}.
FT   MOD_RES    3173   3173       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
SQ   SEQUENCE   6064 AA;  670028 MW;  258D6410F2A108D9 CRC64;
     MAQSTKCYLP RFASTVDGPK RPVSMKTRPT AAQHAQLLTA WNEGRLDPIL RATWALLLHY
     YIRSEDICFG YQHLEGDSRS PKSSVQRSTV NISTIRISIN DNDSLKAIVD KVRANSAIRQ
     NNGSPEASEA YLPFNTIFML RTYDPPASPS KPILATAIPD ECQVRLHVKV LRGDISIFLE
     WRKGDMSGEQ MKSIANIFEQ LLAKVLSAEN TAISQLNLFS ENDWQRIRKW NSTTPQLHDR
     CIHEAIHDQM LSGPDREAVC AWDGSLTFAE LDHQASKLAC YLRMQGVGPE IRVALCFDKS
     KWNIVAMLGV MKAGGAFVPL DPSHPTSRLQ GLIQSVEAPV VLCSQHLADK LRPIVKTLIP
     LCADTLDPLS DPTDSVNLAS GVTSQNAAYV LFTSGSTGEP KGTLLEHRAF LSGAMVHGPG
     LRIYRDSRCL QFAAHTFDAS LAETLTPLIH GACVCIPSEE ARLNDIVSTI NEMRVTQACF
     TPSFIGFIEI ESVPGLESLV LAGEAMSQSQ LTTWSKIKLV NGYGPTEASV ASVLNSNVTP
     DTDCKDIGLP IGVRAWLVNP DNHDELVPVG CPGELLLEGP PLARCYVNNP QKTNESFIYD
     PAWTTLDPET GSNRRFYKTG DLARYNSDTG ALNYVGRKDT QVKVHGQRIE LGEIENQLSK
     DSNVTHCSVF FPKTGFSKGR LAAVVSSTGL LAEQSDSDLE PLRLVPASKK AELVPGIRER
     LSARLPTYMV PAVWLCVEAL PLLPSGKLDR KGISTWVAGM ESDPDLQNGT SAAIVDAEAS
     QPANDREEAL AAVYSRVLNI PQNQLNLNES FLALGGDSIA AMTCIGLCKK RGFALSVQEL
     LRSKSIRDLA TRAKTIDHLT TYEEAVDEPF SLSPIQSLHF GVRKEGQGHF NQGILTRLNK
     PVDERTLRKA VETLVSRHSM LRARFTDTGF ATASSQHITR DIKGSYRWRM HTLANMNEVE
     THVADSQSSI NCFSGPLLAV DYFLVKGRPN VLSMTAHHLV VDIVSWRIIL EDLEDIILNP
     EKTGTSDGSL PFQTWCRLQN EHCNTLRAEH KVATDALAVP DFGYWGLKDT QTTYGDVDCA
     SFEIDPAHTN AILLECHKAL GTEPIDLFLA AMLHSFGRAF PDRSLPTIYN EGHGREVWDP
     SIDISHTVGW FTILHPIFVS AYKSDSPIDT LIQVKDLRRR VTDNGRADFT SRVLPAQGNQ
     GSKHPHPFEM SFNYVGQHRD LQRKDGLFQL VDQMAGEAGQ GGGAADFGSD TPRFGLFEIS
     AMVVAGKVRF NFSFNKFMQH QNRIHRWVSE CQELLVTLSE QLPTLEPRLT LSSFPMLSLT
     YPTLDKLLNE KLPAMGIESP DFVEDIYPCS RMQQGILLGR KRDSSYYAVH DTFEIRATGS
     GKPNLDRLVN AWQKVVSHHA MFRTIFVENL TPRDPFCQVV LKSYDATPVF LQSSGEKDVL
     ATFDKEDPKD YSEPEPAYRF SICQTPTGRL FARIEISHAA MDGNSISIIL RDLQLAYAGR
     LEESPQPLFK DYIQYMQDAP NEASISYWRS YLDQAKPCHF PALTDGQQSA KALRSIPVNF
     GALDELQTVC EKRGITLANV FNAAWGLTLR AFCGSDDVSF SYMASLRDVS ADGVQWVVGP
     VINLLICRMK VADDAKLSDV LHQIQNDYME SLPYRHTSLI EIQHALKLSD TNLFNSGVSY
     RRLPSSKDAV SSEIECAEVG SIHDPAEFPV FINIEAMDTT ARIDLNYWTT NLSDSQAANV
     ANTYLRCLEN VVSNIDCEIR QLNNLSEDNR AQIMAWNSKT HKPFEKCAHH VVQEMAKKRS
     DALAVTAWDG NLTYSKLDQF SSRLAGYLVT FGVGPGTLIP ICFEKSIWNI VSTLAIMKAG
     GGCIPVDTPE SLAAVENWIV DNAVQVALAS PEKAHVLEDA VPYVIPVSES LLEYLADEDL
     NPVAQSSDVA YVAMTAGTSG PAKSVVLDHS TVMTRAEAFA TTMAIADVSR TLQFAPHTSD
     AFIVEAFATF MWGGCICIPA DIDPLNLAAC INALHVNVAS ITPTAASFFS PKDVPGLRSI
     ALGGEVVPQS VLDHWKTDDL QLQVLYGTCE SSAASFHVFC SQEEHEAALI GKSTSCVSWV
     VDPSNHENLV PIGSVGELAL EGPVIASGYL DDQSVETSDF FENAPWLSGQ RGGRKHRLFK
     TGDLVRYKSD GSLVFVGRKN DKSQSALASE LIQTQTRIDT FLEKKKCVVE SVQLQRGDMK
     TNALVAFVVF SDTIPVTYGD RVLQSATPGM KDAMSSLHAS LSTSLPGSKV PSFYIPISSL
     PLTVSGKLNR QALKFETQAL SSSALEAFDI KHWNGSKTGN RAARQASLSG PNIAFWKEYL
     ADVEPCIFPA LSHEASANAR SIRTLNKQSA NIHAFSRLSG LPVETLFQFA WAVVLRWYTG
     SDDVCFGYSA AASETKSEAD GVSTCRFLVQ NEQKLQETLQ KAKRDCETSA LNVAPLDAVK
     HQLGLDNTTL FNTSLIYRTA SNLPKGSTRE PSTSSAYKIL VEAEVSHSYA EIHFTYSSDT
     LSSFQVSHVM DMFDQVLDDL IAHNLRDRTI GDVNVLPERS VRRIRDWNAA SPPRVEKCAD
     ELIQQQALLH PRAEAVCSWD KNFTYGQLEI VSSRLARHLS SLGVKPEAFV VLCFEKSAWA
     VVAQLAVLKA GGAFVSIDPS HPDSRLKMLI DEIGTNLVLC SSSVHTKVSK LCTKSFAVCQ
     TSISQLPDSP LALPGARPTP NNAAYAIFTS GTTGKPKATV VEHTALSTTA IAMIDGLHMN
     STTRALQFSN YTFDVSILEI MMILMTGGCV CIPSEDERMN NLGGAIRRME ATYISAPPAI
     VNTLEPKNVP SLKVIITGGE KMPANHIDRW ADRCVINAYG PSEATVVATV GVKVDWDGNR
     VNDDPTSIGT SPNCRVWIVD PNNSNRLLPV GAVGELILEG SNIARGYLAN EEKTKASFFE
     NPVWNRHSGL QGVFKRNDRM YRTGDLVRYN SDGSLAFISR KDTQIKFNGQ RIELEEIEQQ
     CIRCLPEDSQ VAVDVVVPEE RTIAKGLAAF FTVHDPDSNG GSNDQFAPTV PGADPLLLPI
     SMSNMDAIQK LKGSLPELLP QSMMPRLFFP IRNLPFTSSG KIDRRRLRAM VQTLSKDTLK
     SYITLTTSDR REISSATGLE IKLVALVEKT LELEAGSVTV DDSFFGLGGD SLSAMNLVGA
     AQAEGIALTV SGIFNSPILV DMAKSCVVSD GPAEVKKEDI KAFSLLPSGV YLENLMDEVT
     DSCEVSKDLI SDIYPCSAVQ EGLLTLSIKH NGAYVAQPSF RLAAGIDVGK FKQAWQQTVS
     DLEILRTRIV HTEAMNFAQV VLKDGPISWV EAESFDSLPN DFLHLPKQNG AALTGYAMVH
     PRGSSDSYFV WSVHHALYDG WSIPLVFRKV EENYFSSQPK RAGTPYSLFI DYLAKKDMEE
     SDAFWKSYLT DLSSTPFPHN KNAVPDAMRA GNTQYHNMKL SRTRNSVDFT IPVLMRAAWA
     IVIATHTASG DVCFGETLSG RNIDLPGVAD IAGPVLTTVP TRVQVDNAMS TMQYLQKIHQ
     STTEMIPHLH SGLQRIRQLN KDTSEGCNFQ NLLVIQPGDG ELDNKIWIDE KRETSEDFFT
     HPLVVECGIT KTSISFTVHH DELVISGWHT KRLTEQFAHV LQQLIALPKN STSKLEDLEV
     VSPEDKAEIG TWNERIPLTV ERTVQDFIRE KSEETPNAQA VCAWDGDITY REFWNLASGF
     ANYLVSRGVG PEVFVPVCLD KSAWAMVTLI SILIAGGGYV PLDPSHPTSR HEEILADVGA
     NMILCTPNYT NRYSRVVKTV IPISKETIKA YGALKSSSRR RTDVKPTNMA YALFTSGSTG
     RAKGIIVEHR NVVSSIMAFA PWVRMDETSR VFQFASLTFD AAVMETLAIL MLGGTICVPS
     EDDRLNDVAG AIRRLNVTWT FLTPSIASII EPSSVPSLKH LVCGGEKMSN EVITKWANSV
     HLMNGYGPTE TCVFAVIDNA VATNRDPGRI GYGIPSTLTW IVDPDNHDRL TPLGAVGELA
     LEGAPLAREY LKNPEKNAEA FTSDPAWIKD FTPAIPGPRR IYKTGDLCYY NPDGSIQYIS
     RKDHQVKLHG QRMELGEIEH RLSEDALTRH AVVVLPKNGP LKQRLVTVMS LNSVAADTKL
     ISDKPCELVD ENELERHAYN ELVEVQKNLE NQLPIYMVPQ TWALIKKLPM LVSGKLDRKK
     ITAWVEDIDD ASYERIMADY DRIKRGKIEE KPQEKEEKHG SLSIIREIFA QVLNISLQKV
     NVDRSFVSLG GDSITGMAVI SRARKQGLVV TLHDILQSRS LKELAQTASS KAPVSQREEK
     SGDGFALSPV QRLYFQSSDS FKGAARFNQS MTVRIARRCE GEVLKRAVKA VIGQHAMFRA
     RFSTSSDGTW QQKTAAVGSL QIPDRTFSNS TSQEVDESFQ FRVHSVADIR GMVPKIAESQ
     NCLDPLNGPI LAADLFNLRT GGQVLFLVAH HLCIDMVSWR IVLQDLEELV VSGSLSLDKA
     LSFQSWCAMQ TERAKIQDAT ISLPFTPEKP SLLYWGMQGS PNVYGDIKME SFMLSEDTTK
     FILDGCHSVF RTDTVDILLS AIIYSFGRTF TDRRVPTIYN EGHGREAWEA DIDLSRTVGW
     FTTMAPLLVD SEARALNDII KRVKDTRRKI ADNGRPYFAK NLLQDQGSDF PVPLEILFNY
     LGKMQQLERA DSLFHHHGSV FDSSDFAVAG DMGPQTARFA LFEVSAIVIK ERLNVAFTYN
     NKMQHQGSIR RWILQCKQTL DKDILTLKTA TPEPTLSDYP LLPINYHGLQ MLTASTFRKA
     GIRNKDDVED IYPCSPMQEG LLLSQLRDPN AYMFHTVFEI KDGKSGKVDA EGVARAWQAL
     VDRHPVLRTI FVDSNYTGGS FDQLVLKNLS DNILRVQCQD SQVEEKLAAI SLRDRNAMRQ
     AKLSHQLTVC KTNTGRVILK LEMNHAIIDG GSVDVLLRDL TLAYERKIAE GSGPLFSDYI
     KLIRTQSHSD ALSHWKEYLG GVHPCHLAPS AVFEAKRELK GVKMNFQRFP ELLKFCERSS
     VTLANLTLSA WAIVLRQFVG SDDVCFGYLS AGRDAPVDGI QDMVGIFINM LCCRVQFSDQ
     QTLTDVSKSV QDDYIRCIPH QSCSLASIQH ELGWQGQSLF NTTLSIQNHS VAGGPKDKGL
     SFDLQHAHDP SEYAVTVNVE IARGQEGILL RYWNDIVSDE EAQSLADTIA KVFTGFIESP
     AATLSQSTFA SEAEPESVDW DRSQTTLADK AKSTGEAIDS SAMQKIIDDR VHEIIGQMLR
     EGKLTVPPIR TEGLSSYGGH TDTIADSPYQ LGIQGADDSG VCSATSRSSE DGMSVDVERK
     LWNLWSTALG LSPNVVRHQD SFFKLGGDSI TAMKMVSAAR EEGLVLTVAD VFNNPVFEDM
     LTTVRAANVT QQMLNADLKS GGHKEVDSDL LNITPTTLGP SPSTESLEVL KPSCVDDAAV
     QRGICPKVGV FKGGIADVLP VTDFQAMSLT ATLFKSRWML NYFYLEGNGP LDLRRLRESC
     LKVVAAFDIL RTVFVCFHDQ FFQVVLRKIR PSIFVYETDR ALDEFTMTLQ QRDREYGPRE
     GEQYVQFYVV KKKNSDQHRI MIRLSHTQYD GVCLPKIMAA IKHGYEGTPL PPVTPFAGYL
     RQLPGTITPD HYRHWTDLLK GSHMTQVVRR RGTSMFQNVG AFTEIHRKIE ISPTALGNVT
     IATVMQAAWA LALAKLSAQS DVIFGLTISG RNATVPGIES TVGPCVNVIP VRVKFDEKWT
     GVDLFRYLQD QQVSNMPFES LGFREIIKQC TDWPDWTYFT TSVFHQNVDY EGNMQLDNNK
     YRMGGVGVND NLADLTMVSR PSGERGLDVT LGYSEKGPVM PSFASKVLDM ACEIAQSLVA
     NPTASLPSAS MLRSLPPQTI DDQPRPTDEH FLSAHLKSRS IAELLVHSDI LSRSWHQVLP
     SRTTTGPVDP EADKPTHQSA FQLDSSFFDL GGDVFNLAQL TWLLEQEGLK VRLEDLIEHP
     SFLGQMAVLA LHNAKHQEDM PTELLATGAA PPDPVARIEK KKTWSKAMTI ARKLTGRNTV
     TSRA
//

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