(data stored in SCRATCH zone)

SWISSPROT: B6HD70_PENRW

ID   B6HD70_PENRW            Unreviewed;       209 AA.
AC   B6HD70;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 51.
DE   RecName: Full=5-formyltetrahydrofolate cyclo-ligase {ECO:0000256|RuleBase:RU361279};
DE            EC=6.3.3.2 {ECO:0000256|RuleBase:RU361279};
GN   ORFNames=Pc20g01330 {ECO:0000313|EMBL:CAP85462.1}, PCH_Pc20g01330
GN   {ECO:0000313|EMBL:CAP85462.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP85462.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP85462.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- CATALYTIC ACTIVITY: ATP + 5-formyltetrahydrofolate = ADP +
CC       phosphate + 5,10-methenyltetrahydrofolate.
CC       {ECO:0000256|RuleBase:RU361279}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU361279};
CC   -!- SIMILARITY: Belongs to the 5-formyltetrahydrofolate cyclo-ligase
CC       family. {ECO:0000256|RuleBase:RU361279}.
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DR   EMBL; AM920435; CAP85462.1; -; Genomic_DNA.
DR   RefSeq; XP_002562692.1; XM_002562646.1.
DR   ProteinModelPortal; B6HD70; -.
DR   STRING; 500485.XP_002562692.1; -.
DR   EnsemblFungi; CAP85462; CAP85462; PCH_Pc20g01330.
DR   GeneID; 8312270; -.
DR   KEGG; pcs:Pc20g01330; -.
DR   eggNOG; KOG3093; Eukaryota.
DR   eggNOG; COG0212; LUCA.
DR   HOGENOM; HOG000007299; -.
DR   KO; K01934; -.
DR   OMA; STIYPCQ; -.
DR   OrthoDB; EOG092C4TVL; -.
DR   BioCyc; PCHR:PC20G01330-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c20.
DR   GO; GO:0030272; F:5-formyltetrahydrofolate cyclo-ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR002698; FTHF_cligase.
DR   PANTHER; PTHR23407:SF8; PTHR23407:SF8; 1.
DR   Pfam; PF01812; 5-FTHF_cyc-lig; 1.
DR   PIRSF; PIRSF006806; FTHF_cligase; 1.
DR   TIGRFAMs; TIGR02727; MTHFS_bact; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6HD70.
DR   SWISS-2DPAGE; B6HD70.
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR006806-1,
KW   ECO:0000256|RuleBase:RU361279};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Magnesium {ECO:0000256|RuleBase:RU361279};
KW   Metal-binding {ECO:0000256|RuleBase:RU361279};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR006806-1,
KW   ECO:0000256|RuleBase:RU361279};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   NP_BIND       7     11       ATP. {ECO:0000256|PIRSR:PIRSR006806-1}.
FT   NP_BIND     146    154       ATP. {ECO:0000256|PIRSR:PIRSR006806-1}.
FT   BINDING      53     53       Substrate; via carbonyl oxygen.
FT                                {ECO:0000256|PIRSR:PIRSR006806-1}.
FT   BINDING      59     59       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR006806-1}.
SQ   SEQUENCE   209 AA;  23157 MW;  448314E98BDBD0AD CRC64;
     MAFQAAKRDL RKRMRSTLQG LSATSISQQS SAATTTFLSL PEYQTAKSIA VYLSMPSGEL
     STTGIVKDAL QRGKNVYIPY IHTQGKTSIM DMFALGSVSE FESLQRDKWG IPSLLSTQIE
     GRPNGLAQGL DLIVMPGMAF DHGFRRLGHG KGYYDHFLTR YSTSTHKMPF LVALSLQEQL
     LAEDIPVVEH DWLVDAIVVG DGQFLNRRA
//

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