(data stored in SCRATCH zone)

SWISSPROT: B6HE41_PENRW

ID   B6HE41_PENRW            Unreviewed;       379 AA.
AC   B6HE41;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   05-JUL-2017, entry version 54.
DE   SubName: Full=Pc20g04710 protein {ECO:0000313|EMBL:CAP85800.1};
GN   ORFNames=Pc20g04710 {ECO:0000313|EMBL:CAP85800.1}, PCH_Pc20g04710
GN   {ECO:0000313|EMBL:CAP85800.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP85800.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP85800.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- SIMILARITY: Belongs to the asparaginase 1 family.
CC       {ECO:0000256|RuleBase:RU004456}.
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DR   EMBL; AM920435; CAP85800.1; -; Genomic_DNA.
DR   RefSeq; XP_002563013.1; XM_002562967.1.
DR   ProteinModelPortal; B6HE41; -.
DR   STRING; 500485.XP_002563013.1; -.
DR   EnsemblFungi; CAP85800; CAP85800; PCH_Pc20g04710.
DR   GeneID; 8314568; -.
DR   KEGG; pcs:Pc20g04710; -.
DR   eggNOG; KOG0503; Eukaryota.
DR   eggNOG; COG0252; LUCA.
DR   HOGENOM; HOG000044165; -.
DR   KO; K01424; -.
DR   OMA; VRKNHTS; -.
DR   OrthoDB; EOG092C3Z6Q; -.
DR   BioCyc; PCHR:PC20G04710-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c20.
DR   GO; GO:0004067; F:asparaginase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006528; P:asparagine metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1170; -; 1.
DR   Gene3D; 3.40.50.40; -; 1.
DR   InterPro; IPR004550; AsnASE_II.
DR   InterPro; IPR006034; Asparaginase/glutaminase-like.
DR   InterPro; IPR020827; Asparaginase/glutaminase_AS1.
DR   InterPro; IPR027475; Asparaginase/glutaminase_AS2.
DR   InterPro; IPR027473; L-asparaginase_C.
DR   InterPro; IPR027474; L-asparaginase_N.
DR   Pfam; PF00710; Asparaginase; 1.
DR   PIRSF; PIRSF001220; L-ASNase_gatD; 1.
DR   PRINTS; PR00139; ASNGLNASE.
DR   SMART; SM00870; Asparaginase; 1.
DR   SUPFAM; SSF53774; SSF53774; 1.
DR   TIGRFAMs; TIGR00520; asnASE_II; 1.
DR   PROSITE; PS00144; ASN_GLN_ASE_1; 1.
DR   PROSITE; PS00917; ASN_GLN_ASE_2; 1.
DR   PROSITE; PS51732; ASN_GLN_ASE_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6HE41.
DR   SWISS-2DPAGE; B6HE41.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    379       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002845609.
FT   DOMAIN       49    240       Asparaginase. {ECO:0000259|Pfam:PF00710}.
FT   REGION      139    140       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR001220-2}.
FT   ACT_SITE     58     58       Acyl-ester intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR604550-50}.
FT   ACT_SITE     58     58       O-isoaspartyl threonine intermediate.
FT                                {ECO:0000256|PIRSR:PIRSR001220-1}.
FT   BINDING     105    105       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR001220-2}.
SQ   SEQUENCE   379 AA;  39815 MW;  6F9D521EAD6FB6CE CRC64;
     MGFSLQALTV SALAITSYAS PLIHSRATNT SYTNSNGLTF NHFNGSLPNV TILATGGTIA
     GTSDDKTATA GYESGALGIN TLLSKIPEIF NVANIAAVQA HNVNSGDISS SLLLNLTHTL
     QATVCDDPTM SGAVITHGTD TLEESAFFID ATVNCGKPIV FVGSMRPATA ISADGPMNLV
     QGVTVAADND SRDRGALVVL NDRIVSALFA TKTHANTMDT FKAYEQGNLG FIVSNKPYFY
     YPAVQANVKH VVDVSNVDSV PRVDILYAYE DMQVDSLYSA MKNGAKGIVV AGEGAGGVAT
     DFGSAINDIV KKHNIPVVLS HRTVNGEVPT ADFTGEDAQT KIASGLFNPQ QARILLGLLL
     AEKKGLKEIR EVFLKATVA
//

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