(data stored in SCRATCH zone)

SWISSPROT: B6HG21_PENRW

ID   B6HG21_PENRW            Unreviewed;       504 AA.
AC   B6HG21;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 60.
DE   RecName: Full=Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|RuleBase:RU362120};
DE            EC=1.1.1.49 {ECO:0000256|RuleBase:RU362120};
GN   ORFNames=Pc20g03330 {ECO:0000313|EMBL:CAP85662.1}, PCH_Pc20g03330
GN   {ECO:0000313|EMBL:CAP85662.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP85662.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP85662.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: Catalyzes the rate-limiting step of the oxidative
CC       pentose-phosphate pathway, which represents a route for the
CC       dissimilation of carbohydrates besides glycolysis.
CC       {ECO:0000256|RuleBase:RU362120}.
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-
CC       glucono-1,5-lactone + NADPH. {ECO:0000256|RuleBase:RU362120}.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 1/3. {ECO:0000256|RuleBase:RU362120}.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU362120}.
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DR   EMBL; AM920435; CAP85662.1; -; Genomic_DNA.
DR   RefSeq; XP_002562885.1; XM_002562839.1.
DR   STRING; 500485.XP_002562885.1; -.
DR   EnsemblFungi; CAP85662; CAP85662; PCH_Pc20g03330.
DR   GeneID; 8317561; -.
DR   KEGG; pcs:Pc20g03330; -.
DR   eggNOG; KOG0563; Eukaryota.
DR   eggNOG; COG0364; LUCA.
DR   HOGENOM; HOG000046192; -.
DR   KO; K00036; -.
DR   OMA; VEICVYE; -.
DR   OrthoDB; EOG092C2MOH; -.
DR   BioCyc; PCHR:PC20G03330-MONOMER; -.
DR   UniPathway; UPA00115; UER00408.
DR   Proteomes; UP000000724; Contig Pc00c20.
DR   GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00966; G6PD; 1.
DR   InterPro; IPR001282; G6P_DH.
DR   InterPro; IPR019796; G6P_DH_AS.
DR   InterPro; IPR022675; G6P_DH_C.
DR   InterPro; IPR022674; G6P_DH_NAD-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   PANTHER; PTHR23429; PTHR23429; 1.
DR   Pfam; PF02781; G6PD_C; 1.
DR   Pfam; PF00479; G6PD_N; 1.
DR   PIRSF; PIRSF000110; G6PD; 1.
DR   PRINTS; PR00079; G6PDHDRGNASE.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00871; zwf; 1.
DR   PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6HG21.
DR   SWISS-2DPAGE; B6HG21.
KW   Carbohydrate metabolism {ECO:0000256|RuleBase:RU362120};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Glucose metabolism {ECO:0000256|RuleBase:RU362120};
KW   NADP {ECO:0000256|RuleBase:RU362120};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU362120};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   DOMAIN       17    196       G6PD_N. {ECO:0000259|Pfam:PF00479}.
FT   DOMAIN      198    486       G6PD_C. {ECO:0000259|Pfam:PF02781}.
SQ   SEQUENCE   504 AA;  58306 MW;  71DA543FFA92F43F CRC64;
     MDMAFSTIEL KDDTIIVVLG ASGDLAKKKT FPALFGLFRN KFLPKDIRIV GYARTKMDTD
     EYLKRVRSYI KVPTKEIEDQ LDQFCKMCTY VSGQYDQDDS FINLNKHLEE IENNRQSKEQ
     NRVFYMALPP SVFTTVSDQL KRNCYPKSGL ARIIVEKPFG KDLQSSRDLQ KALEPNWKEE
     EIFRIDHYLG KEMVKNILIL RFGNEFFNAT WNRRHIDNVQ ITFKEPFGTE GRGGYFDEFG
     IIRDVMQNHL LQVLTLLAME RPISFSSEDI RDEKVRVLRA MDAIEPKNVI IGQYGRSLDG
     SKPGYLEDDT VPKESRCPTF CAMVAYIKNE RWDGVPFILK AGKALNEQKT EVRIQFKDVT
     SGIFKDIPRN ELVIRVQPNE SVYIKMNSKL PGLSMQTVVT ELDLTYRRRF SDLKIPEAYE
     SLILDAFKGD HSNFVRDDEL DASWRIFTPL LHYLDDNKEI IPMEYPYGSR GPAVLDDFTA
     SYGYKFSDAA GYQWPVTTSA PNRL
//

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