(data stored in SCRATCH zone)

SWISSPROT: B6HGF8_PENRW

ID   B6HGF8_PENRW            Unreviewed;       939 AA.
AC   B6HGF8;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   05-JUL-2017, entry version 53.
DE   SubName: Full=Pc20g03600 protein {ECO:0000313|EMBL:CAP85689.1};
GN   ORFNames=Pc20g03600 {ECO:0000313|EMBL:CAP85689.1}, PCH_Pc20g03600
GN   {ECO:0000313|EMBL:CAP85689.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP85689.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP85689.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
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DR   EMBL; AM920435; CAP85689.1; -; Genomic_DNA.
DR   RefSeq; XP_002562911.1; XM_002562865.1.
DR   STRING; 500485.XP_002562911.1; -.
DR   EnsemblFungi; CAP85689; CAP85689; PCH_Pc20g03600.
DR   GeneID; 8309965; -.
DR   KEGG; pcs:Pc20g03600; -.
DR   eggNOG; KOG4230; Eukaryota.
DR   eggNOG; COG0190; LUCA.
DR   eggNOG; COG2759; LUCA.
DR   HOGENOM; HOG000040280; -.
DR   KO; K00288; -.
DR   OMA; GTNYIPD; -.
DR   OrthoDB; EOG092C0B4M; -.
DR   BioCyc; PCHR:PC20G03600-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c20.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:InterPro.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   CDD; cd00477; FTHFS; 1.
DR   HAMAP; MF_01543; FTHFS; 1.
DR   HAMAP; MF_01576; THF_DHG_CYH; 1.
DR   InterPro; IPR000559; Formate_THF_ligase.
DR   InterPro; IPR020628; Formate_THF_ligase_CS.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000672; THF_DH/CycHdrlase.
DR   InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR   InterPro; IPR020867; THF_DH/CycHdrlase_CS.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   Pfam; PF01268; FTHFS; 1.
DR   Pfam; PF00763; THF_DHG_CYH; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   PRINTS; PR00085; THFDHDRGNASE.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00721; FTHFS_1; 1.
DR   PROSITE; PS00722; FTHFS_2; 1.
DR   PROSITE; PS00767; THF_DHG_CYH_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6HGF8.
DR   SWISS-2DPAGE; B6HGF8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   DOMAIN        6    122       THF_DHG_CYH. {ECO:0000259|Pfam:PF00763}.
FT   DOMAIN      127    289       THF_DHG_CYH_C. {ECO:0000259|Pfam:
FT                                PF02882}.
SQ   SEQUENCE   939 AA;  100561 MW;  BE98D8D65EAE0543 CRC64;
     MAAAKIDGTA IAKSIRQGLK SEIEQIQVNN PRFKPNLVIF QVGSRSDSST YVRMKLKAAQ
     EANIICTLIN VPESSTELEL IQEITKANYD PAIHGILVQL PLPSHMSEHA ITSTVADEKD
     VDGFGAINIG ELAKRGGRPL FTPCTPLAVM ELLKASGVDP AGKEAVVLGR SDIVGSPVSY
     LLKNADATVT VCHSKTPDIA RVVKTADIVV AAIGQTELVK GDWLKPGAVV IDVGINYKPD
     ATKKSGERLV GDVDFESASQ VASQITPVPG GVGPMTVAML LKNVVHSAKG YFEKQKDRHV
     TPLPLRLQTP VPSDIAISRA QYPKPITQIA TEVGIAPHEL EPYGHTKAKI NLSVLDRLAH
     RRNGRYILVA GITPTPLGEG KSTTTLGLTQ ALGAHLNRIS FANVRQPSQG PTFGIKGGAA
     GGGYSQVIPM DEFNLHLTGD IHAITAANNL LAAAIETRMF HESTQKDAAL YKRLVPASKG
     KREFKPIMFR RLKKLGIEKT NPDDLTEEEI TRFARLDIDP ETITWRRVLD VNDRHLRGIT
     VGQADTEKGL SRETGFDISV ASECMAILAL SNDLEDMRER LGRMVVATSR NGDPVTCDDI
     GAGGALAALM KDAIKPNMMQ SLEGTPVMVH AGPFANISIG ASSAIADKLA LKLAGTEPDE
     DHEAKTGFVV TEAGFDFTMG GERFFNIKCR SSGLVPDTVV IVATVRALKV HGGGPEIKPG
     APLQEVYRTE NVDVLRQGCV NLRKHIANAK QYGVPVVVAI NKFETDTDAE IAVIREEAIA
     AGAEDAVPAN HWAEGGAGAV DLAKAVMTAS SKEKHFQLLY GLDGTIQERI ERIGQAMYGA
     EKVEFSELAQ KKVDTYTKQG FSNLPICIAK TQYSLSHDPA LKGAPTGFTV PIRDVRLAVG
     AGYLYALAAD IQTIPGLPTA PGYLNVDIDT ETGDIDGLF
//

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