(data stored in SCRATCH zone)

SWISSPROT: B7UI66_ECO27

ID   B7UI66_ECO27            Unreviewed;       388 AA.
AC   B7UI66;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 64.
DE   RecName: Full=Na(+)/H(+) antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
DE   AltName: Full=Sodium/proton antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
GN   Name=nhaA {ECO:0000256|HAMAP-Rule:MF_01844,
GN   ECO:0000313|EMBL:CAS07569.1};
GN   OrderedLocusNames=E2348C_0021 {ECO:0000313|EMBL:CAS07569.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS07569.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS07569.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC       for external protons. {ECO:0000256|HAMAP-Rule:MF_01844,
CC       ECO:0000256|SAAS:SAAS00895465}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01844}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01844}.
CC   -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC       family. {ECO:0000256|HAMAP-Rule:MF_01844,
CC       ECO:0000256|SAAS:SAAS00895449}.
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DR   EMBL; FM180568; CAS07569.1; -; Genomic_DNA.
DR   RefSeq; WP_000681384.1; NC_011601.1.
DR   SMR; B7UI66; -.
DR   EnsemblBacteria; CAS07569; CAS07569; E2348C_0021.
DR   KEGG; ecg:E2348C_0021; -.
DR   HOGENOM; HOG000218489; -.
DR   KO; K03313; -.
DR   OMA; LLMWVND; -.
DR   BioCyc; ECOL574521:E2348C_RS00105-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 1.20.1530.10; -; 1.
DR   HAMAP; MF_01844; NhaA; 1.
DR   InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR   InterPro; IPR004670; NhaA.
DR   PANTHER; PTHR30341; PTHR30341; 1.
DR   Pfam; PF06965; Na_H_antiport_1; 1.
DR   TIGRFAMs; TIGR00773; NhaA; 1.
PE   3: Inferred from homology;
DR   PRODOM; B7UI66.
DR   SWISS-2DPAGE; B7UI66.
KW   Antiport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00895439};
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01844};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00919182};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   Ion transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00895467};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00919187, ECO:0000256|SAM:Phobius};
KW   Sodium {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00895461};
KW   Sodium transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00895442};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00919180, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00919177, ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00895454}.
FT   TOPO_DOM      1     11       Cytoplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM     12     39       Helical. {ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM     31     58       Periplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM     59     79       Helical. {ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM     86     94       Cytoplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM     91    114       Helical. {ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM    117    120       Periplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    126    145       Helical. {ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM    144    149       Cytoplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    154    175       Helical. {ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM    176    181       Periplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    181    200       Helical. {ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM    201    204       Cytoplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    207    238       Helical. {ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM    219    222       Periplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TOPO_DOM    237    246       Cytoplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    258    276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM    272    289       Periplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    288    312       Helical. {ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM    312    326       Cytoplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    324    351       Helical. {ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM    351    356       Periplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    363    380       Helical. {ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM    383    388       Cytoplasmic. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
SQ   SEQUENCE   388 AA;  41370 MW;  FA20932181389E50 CRC64;
     MKHLHRFFSS DASGGIILII AAVLAMIMAN SGATSGWYHD FLETPVQLRV GTLEINKNML
     LWINDALMAV FFLLVGLEVK RELMQGSLAS LRQAAFPVIA AIGGMIVPAL LYLAFNYADP
     ITREGWAIPA ATDIAFALGV LALLGSRVPL ALKIFLMALA IIDDLGAIII IALFYTNDLS
     MASLGVAAVA IAVLAVLNLC GVRRTGVYIL VGVVLWTAVL KSGVHATLAG VIVGFFIPLK
     EKHGRSPAKR LEHVLHPWVA YLILPLFAFA NAGVSLQGVT LEGLTSILPL GIIAGLLIGK
     PLGISLFCWL ALRLKLAHLP EGTTYQQIMA VGILCGIGFT MSIFIASLAF GSVDPELINW
     AKLGILVGSI SSAVIGYSWL RVRLRPSV
//

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