(data stored in SCRATCH zone)

SWISSPROT: B7UIC0_ECO27

ID   B7UIC0_ECO27            Unreviewed;       551 AA.
AC   B7UIC0;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 56.
DE   RecName: Full=HTH-type transcriptional regulator SgrR {ECO:0000256|HAMAP-Rule:MF_01449};
GN   Name=sgrR {ECO:0000256|HAMAP-Rule:MF_01449,
GN   ECO:0000313|EMBL:CAS07623.1};
GN   OrderedLocusNames=E2348C_0075 {ECO:0000313|EMBL:CAS07623.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS07623.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS07623.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- FUNCTION: Activates the small RNA gene sgrS under glucose-
CC       phosphate stress conditions as well as yfdZ. Represses its own
CC       transcription under both stress and non-stress conditions. Might
CC       act as a sensor of the intracellular accumulation of
CC       phosphoglucose by binding these molecules in its C-terminal
CC       solute-binding domain. {ECO:0000256|HAMAP-Rule:MF_01449}.
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DR   EMBL; FM180568; CAS07623.1; -; Genomic_DNA.
DR   RefSeq; WP_001339533.1; NC_011601.1.
DR   EnsemblBacteria; CAS07623; CAS07623; E2348C_0075.
DR   KEGG; ecg:E2348C_0075; -.
DR   HOGENOM; HOG000271136; -.
DR   KO; K11925; -.
DR   OMA; WLTWQAE; -.
DR   BioCyc; ECOL574521:E2348C_RS00385-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01449; HTH_type_SgrR; 1.
DR   InterPro; IPR039424; SBP_5.
DR   InterPro; IPR000914; SBP_5_dom.
DR   InterPro; IPR025370; SgrR_HTH_N.
DR   InterPro; IPR023767; Tscrpt_reg_SgrR.
DR   PANTHER; PTHR30290; PTHR30290; 1.
DR   Pfam; PF00496; SBP_bac_5; 1.
DR   Pfam; PF12793; SgrR_N; 1.
PE   3: Inferred from homology;
DR   PRODOM; B7UIC0.
DR   SWISS-2DPAGE; B7UIC0.
KW   Activator {ECO:0000256|HAMAP-Rule:MF_01449};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01449,
KW   ECO:0000313|EMBL:CAS07623.1};
KW   Repressor {ECO:0000256|HAMAP-Rule:MF_01449};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_01449};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01449}.
FT   DOMAIN        5    118       SgrR_N. {ECO:0000259|Pfam:PF12793}.
FT   DOMAIN      165    306       SBP_bac_5. {ECO:0000259|Pfam:PF00496}.
FT   REGION      163    492       Solute-binding. {ECO:0000256|HAMAP-Rule:
FT                                MF_01449}.
SQ   SEQUENCE   551 AA;  64007 MW;  2CC2EF2654CC6284 CRC64;
     MPSARLQQQF IRLWQCCEGK SQDTTLNELA ALLSCSRRHM RTLLNTMQDR GWLTWEAEVG
     RGKRSRLTFL YTGLALQQQR AEDLLEQDRI DQLVQLVGDK AAVRQMLVSH LGRSFRQGRH
     ILRVLYYRPL RNLLPGSALR RSETHIARQI FSSLTRINEE NGELEADIAH HWQQISPLHW
     RFFLRPGVHF HHGRELEMDD VIASLKRINT LPLYSHIADI VSPTPWTLDI HLTQPDRWLP
     LLLGQVPAMI LPREWETLSN FASHPIGTGP YAVIRNSSNQ LKIQAFDDFF GYRALIDEVN
     VWVLPEIADE PAGGLMLKGP QGEEKEIESR LEEGCYYLLF DSRTHRGANQ QVRDWVSYVL
     SPTNLVYFAE EQYQQLWFPA YGLLPRWHHA RPTHCEKPAG LENLTLTFYQ DHIEHRVIAG
     IMQQILASHQ VTLKIKEISY DQWHEGEIES DIWLNSANFT LPLDFSLFAH LCEVPLLQHC
     IPIDWQADAA RWRNGEMNLA NWCQQLVASK AMVPLIHHWL IIQGQRSMRG LRMNTLGWFD
     FKSAWFAPPD P
//

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