(data stored in SCRATCH zone)

SWISSPROT: B7UJA3_ECO27

ID   B7UJA3_ECO27            Unreviewed;       267 AA.
AC   B7UJA3;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 50.
DE   SubName: Full=2,5-diketo-D-gluconate reductase B {ECO:0000313|EMBL:CAS07755.1};
GN   Name=dkgB {ECO:0000313|EMBL:CAS07755.1};
GN   OrderedLocusNames=E2348C_0207 {ECO:0000313|EMBL:CAS07755.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS07755.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS07755.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
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DR   EMBL; FM180568; CAS07755.1; -; Genomic_DNA.
DR   RefSeq; WP_000997014.1; NC_011601.1.
DR   EnsemblBacteria; CAS07755; CAS07755; E2348C_0207.
DR   KEGG; ecg:E2348C_0207; -.
DR   HOGENOM; HOG000250272; -.
DR   KO; K06222; -.
DR   OMA; KIWTENL; -.
DR   BioCyc; ECOL574521:E2348C_RS01095-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd06660; Aldo_ket_red; 1.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR020471; Aldo/keto_reductase.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; PTHR43827; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   4: Predicted;
DR   PRODOM; B7UJA3.
DR   SWISS-2DPAGE; B7UJA3.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205}.
FT   DOMAIN        8    250       Aldo_ket_red. {ECO:0000259|Pfam:PF00248}.
FT   COILED      225    245       {ECO:0000256|SAM:Coils}.
FT   ACT_SITE     39     39       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000097-1}.
FT   BINDING      97     97       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000097-2}.
FT   SITE         64     64       Lowers pKa of active site Tyr.
FT                                {ECO:0000256|PIRSR:PIRSR000097-3}.
SQ   SEQUENCE   267 AA;  29480 MW;  F861F2B06E34EFD5 CRC64;
     MAIPAFGLGT FRLKDDVVIS SVKTALELDY RAIDTAQIYD NEAAVGQAIA ESGVPRHELY
     ITTKIWIENL NKAKLIPSLK ESLQKLRTDY VDLTLIHWPS PNDEVSVEEF MQALLEAKKE
     GLTREIGISN FTIPLMEKAI AAVGAENIAT NQIELSPYLQ NRKVVAWAKQ HGIHITSYMT
     LAYGNALKDK VIARIAAKHN ATPAQVILAW AMGEGYSVIP SSTKRENLES NLKAQNLQLD
     AEDKKAIAAL DCNDRLVSPE GLAPEWD
//

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