(data stored in SCRATCH zone)

SWISSPROT: B7UJM0_ECO27

ID   B7UJM0_ECO27            Unreviewed;      1047 AA.
AC   B7UJM0;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 60.
DE   RecName: Full=Nuclease SbcCD subunit C {ECO:0000256|RuleBase:RU363070};
GN   Name=sbcC {ECO:0000256|RuleBase:RU363070,
GN   ECO:0000313|EMBL:CAS07880.1};
GN   OrderedLocusNames=E2348C_0332 {ECO:0000313|EMBL:CAS07880.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS07880.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS07880.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- FUNCTION: SbcCD cleaves DNA hairpin structures. These structures
CC       can inhibit DNA replication and are intermediates in certain DNA
CC       recombination reactions. The complex acts as a 3'->5' double
CC       strand exonuclease that can open hairpins. It also has a 5'
CC       single-strand endonuclease activity.
CC       {ECO:0000256|RuleBase:RU363070}.
CC   -!- SUBUNIT: Heterodimer of SbcC and SbcD.
CC       {ECO:0000256|RuleBase:RU363070}.
CC   -!- SIMILARITY: Belongs to the SMC family. SbcC subfamily.
CC       {ECO:0000256|RuleBase:RU363070}.
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DR   EMBL; FM180568; CAS07880.1; -; Genomic_DNA.
DR   RefSeq; WP_000698870.1; NC_011601.1.
DR   EnsemblBacteria; CAS07880; CAS07880; E2348C_0332.
DR   KEGG; ecg:E2348C_0332; -.
DR   HOGENOM; HOG000280831; -.
DR   KO; K03546; -.
DR   OMA; LRCAIYR; -.
DR   BioCyc; ECOL574521:E2348C_RS01750-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004592; SbcC_gammaproteobac_type.
DR   SUPFAM; SSF52540; SSF52540; 3.
DR   TIGRFAMs; TIGR00618; sbcc; 1.
PE   3: Inferred from homology;
DR   PRODOM; B7UJM0.
DR   SWISS-2DPAGE; B7UJM0.
KW   Coiled coil {ECO:0000256|RuleBase:RU363070};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   DNA recombination {ECO:0000256|RuleBase:RU363070};
KW   DNA replication {ECO:0000256|RuleBase:RU363070};
KW   Endonuclease {ECO:0000256|RuleBase:RU363070};
KW   Exonuclease {ECO:0000256|RuleBase:RU363070,
KW   ECO:0000313|EMBL:CAS07880.1};
KW   Hydrolase {ECO:0000256|RuleBase:RU363070};
KW   Nuclease {ECO:0000256|RuleBase:RU363070}.
FT   COILED      238    276       {ECO:0000256|RuleBase:RU363070}.
FT   COILED      539    580       {ECO:0000256|RuleBase:RU363070}.
FT   COILED      618    645       {ECO:0000256|RuleBase:RU363070}.
FT   COILED      772    806       {ECO:0000256|RuleBase:RU363070}.
SQ   SEQUENCE   1047 AA;  118480 MW;  B9C4530CFF4F00C1 CRC64;
     MKILSLRLKN LNSLKGEWKI DFTREPFASN GLFAITGPTG AGKTTLLDAI CLALYHETPR
     LSNVSQSQND LMTRDTAECL AEVEFEVKGE AYRAFWSQNR ARNQPDGNLQ VPRVELARCA
     DGKILADKVK DKLELTATLT GLDYGRFTRS MLLSQGQFAA FLNAKPKERA ELLEELTGTE
     IYGQISAMVF EQHKSARTEL EKLQAQASGV ALLTPEQVQS LTASLQVLTD EEKQLITAQQ
     QEQQSLNWLT RLDELQQEAS RRQQALQQAL AEEEKAQPQL AALSLAQPAR NLRPHWERIA
     EHSTALAHTR QQIEEVNTRL QSTMALRTSI RHHAAKQSAE LQQQQQSLNA WLQEHDRFRQ
     WNNELAGWRA QFSQQTSDRE HLRQWQQQLT HAEQKLNALA AITLTLTADE VASALAQHAE
     QRPLRQRLVA LHGQIVPQQK RLAQLQVAIQ NVTLEQTQRN AALNEMRHRY KEKTQQLADV
     KTICEQEARI KTLEAQRAQL QAGQPCPLCG SSSHPAVEAY QALEPGVNQA RLLTLEKEVK
     KLGEEGAALR GQLDALTKQL QRDENEAQSL RQDEQALTQQ WQAVTASLNI TLQPQDDIQP
     WLDAQDEHER QLRLLSQRHE LQGQIAAHNQ QIIQYQQQIE QRQQQLLTAL AGYALTLPQE
     DEEESWLATR QQEAQSWQQR QNELTALQNR MQQLTPILET LPQSDELPHS EETVALENWR
     QVHEQCLALH SQQQTLQQQD VLAAQSLQKA QAQFDTALQA SVFDDQQAFL AALMDEQTLT
     QLEQLKQNLE NQRRQAQTLV TQTAETLTQH QQHRPGGLSL TVTVEQIQQE LAQTHQKLRE
     NTTSQGEIRQ QLKQDADNRQ QQQTLMQQIA QMTQQVEDWG YLNSLIGSKE GDKFRKFAQG
     LTLDNLVHLA NQQLTRLHGR YLLQRKASEA LEVEVVDTWQ ADAVRDTRTL SGGESFLVSL
     ALALALSDLV SHKTRIDSLF LDEGFGTLDS ETLDTALDAL DALNASGKTI GVISHVEAMK
     ERIPVQIKVK KINGLGYSKL ESAFAVK
//

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