(data stored in SCRATCH zone)

SWISSPROT: B7UKG0_ECO27

ID   B7UKG0_ECO27            Unreviewed;       550 AA.
AC   B7UKG0;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 55.
DE   SubName: Full=Bifunctional UDP-sugarhydrolase/5'-nucleotidase {ECO:0000313|EMBL:CAS07963.1};
GN   Name=ushA {ECO:0000313|EMBL:CAS07963.1};
GN   OrderedLocusNames=E2348C_0415 {ECO:0000313|EMBL:CAS07963.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS07963.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS07963.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- SIMILARITY: Belongs to the 5'-nucleotidase family.
CC       {ECO:0000256|RuleBase:RU362119}.
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DR   EMBL; FM180568; CAS07963.1; -; Genomic_DNA.
DR   RefSeq; WP_000771747.1; NC_011601.1.
DR   EnsemblBacteria; CAS07963; CAS07963; E2348C_0415.
DR   KEGG; ecg:E2348C_0415; -.
DR   HOGENOM; HOG000247216; -.
DR   KO; K11751; -.
DR   OMA; KRLFKPY; -.
DR   BioCyc; ECOL574521:E2348C_RS02175-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 3.90.780.10; -; 1.
DR   InterPro; IPR008334; 5'-Nucleotdase_C.
DR   InterPro; IPR036907; 5'-Nucleotdase_C_sf.
DR   InterPro; IPR006146; 5'-Nucleotdase_CS.
DR   InterPro; IPR006179; 5_nucleotidase/apyrase.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PANTHER; PTHR11575; PTHR11575; 1.
DR   Pfam; PF02872; 5_nucleotid_C; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR01607; APYRASEFAMLY.
DR   SUPFAM; SSF55816; SSF55816; 1.
DR   PROSITE; PS00785; 5_NUCLEOTIDASE_1; 1.
DR   PROSITE; PS00786; 5_NUCLEOTIDASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; B7UKG0.
DR   SWISS-2DPAGE; B7UKG0.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   Hydrolase {ECO:0000256|RuleBase:RU362119,
KW   ECO:0000313|EMBL:CAS07963.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362119};
KW   Signal {ECO:0000256|RuleBase:RU362119}.
FT   SIGNAL        1     25       {ECO:0000256|RuleBase:RU362119}.
FT   CHAIN        26    550       {ECO:0000256|RuleBase:RU362119}.
FT                                /FTId=PRO_5005123889.
FT   DOMAIN       35    254       Metallophos. {ECO:0000259|Pfam:PF00149}.
FT   DOMAIN      363    509       5_nucleotid_C. {ECO:0000259|Pfam:
FT                                PF02872}.
SQ   SEQUENCE   550 AA;  60825 MW;  DBA073B6E2CE6AD7 CRC64;
     MKLLQRGVAL ALLTTFTLAS ETALAYEQDK TYKITVLHTN DHHGHFWRNE YGEYGLAAQK
     TLVDGIRKEV AAEGGSVLLL SGGDINTGVP ESDLQDAEPD FRGMNLVGYD AMAIGNHEFD
     NPLTVLRQQE KWAKFPLLSA NIYQKSTGER LFKPWALFKR QDLKIAVIGL TTDDTAKIGN
     PEYFTDIEFR KPADEAKLVI QELQQTEKPD IIIAATHMGH YDNGEHGSNA PGDVEMARAL
     PAGSLAMIVG GHSQDPVCMA AENKKQVDYV PGTPCKPDQQ NGIWIVQAHE WGKYVGRADF
     EFRNGEMKMV NYQLIPVNLK KKVTWEDGKS ERVLYTPEIA ENQQMISLLS PFQNKGKAQL
     EVKIGETNGR LEGDRDKVRF VQTNMGRLIL AAQMDRTGAD FAVMSGGGIR DSIEAGDISY
     KNVLKVQPFG NVVVYADMTG KEVIDYLTAV AQMKPDSGAY PQFANVSFVA KDGKLDDLKI
     KGEPVDPAKT YRMATLNFNA TGGDGYPRLD NKPGYVNTGF IDAEVLKAYI QKSSPLDVSV
     YEPKGEVSWQ
//

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