(data stored in SCRATCH zone)

SWISSPROT: B7UKR0_ECO27

ID   B7UKR0_ECO27            Unreviewed;       352 AA.
AC   B7UKR0;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   10-APR-2019, entry version 55.
DE   RecName: Full=[Citrate [pro-3S]-lyase] ligase {ECO:0000256|PIRNR:PIRNR005751};
DE            EC=6.2.1.22 {ECO:0000256|PIRNR:PIRNR005751};
GN   Name=citC {ECO:0000313|EMBL:CAS08067.1};
GN   OrderedLocusNames=E2348C_0519 {ECO:0000313|EMBL:CAS08067.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS08067.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS08067.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- FUNCTION: Acetylation of prosthetic group (2-(5''-phosphoribosyl)-
CC       3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.
CC       {ECO:0000256|PIRNR:PIRNR005751}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetate + ATP + holo-[citrate lyase ACP] = acetyl-
CC         [citrate lyase ACP] + AMP + diphosphate; Xref=Rhea:RHEA:23788,
CC         Rhea:RHEA-COMP:10158, Rhea:RHEA-COMP:13710, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:82683,
CC         ChEBI:CHEBI:137976, ChEBI:CHEBI:456215; EC=6.2.1.22;
CC         Evidence={ECO:0000256|PIRNR:PIRNR005751};
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; FM180568; CAS08067.1; -; Genomic_DNA.
DR   RefSeq; WP_000467711.1; NC_011601.1.
DR   EnsemblBacteria; CAS08067; CAS08067; E2348C_0519.
DR   KEGG; ecg:E2348C_0519; -.
DR   HOGENOM; HOG000117934; -.
DR   KO; K01910; -.
DR   OMA; GHQYLVE; -.
DR   BioCyc; ECOL574521:E2348C_RS02725-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0008771; F:[citrate (pro-3S)-lyase] ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009058; P:biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd02169; Citrate_lyase_ligase; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR005216; Citrate_lyase_ligase.
DR   InterPro; IPR013166; Citrate_lyase_ligase_C.
DR   InterPro; IPR004821; Cyt_trans-like.
DR   InterPro; IPR000182; GNAT_dom.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR40599; PTHR40599; 1.
DR   Pfam; PF08218; Citrate_ly_lig; 1.
DR   PIRSF; PIRSF005751; Acet_citr_lig; 1.
DR   SMART; SM00764; Citrate_ly_lig; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   TIGRFAMs; TIGR00124; cit_ly_ligase; 1.
DR   TIGRFAMs; TIGR00125; cyt_tran_rel; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   4: Predicted;
DR   PRODOM; B7UKR0.
DR   SWISS-2DPAGE; B7UKR0.
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR005751};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   Ligase {ECO:0000256|PIRNR:PIRNR005751};
KW   Lyase {ECO:0000313|EMBL:CAS08067.1};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR005751}.
FT   DOMAIN        1    128       N-acetyltransferase.
FT                                {ECO:0000259|PROSITE:PS51186}.
SQ   SEQUENCE   352 AA;  40076 MW;  99E5AF1CDEFE8156 CRC64;
     MFGNDIFTRV KRSENKKMAE IAQFLHENDL SVDTTVEVFI TVTRDEKLIA CGGIAGNIIK
     CVAISESVRG EGLALTLATE LINLAYERHS THLFIYTKTE YEALFRQCGF STLTSVPGVM
     VLMENSATRL KRYAESLKKF RHPGNKIGCI VMNANPFTNG HRYLIQQAAA QCDWLHLFLV
     KEDSSRFPYE DRLNLVLKGT ADIPRLTVHR GSEYIISRAT FPCYFIKEQS VINHCYTEID
     LKIFRQYLAP ALGVTHRFVG TEPFCRVTAQ YNQDMRYWLE TPTISAPPIE LVEIERLRYQ
     EMPISASRVR QLLAKNDLTA IAPLVPAVTL HYLQNLLEHS RQDAAARQKT PA
//

If you have problems or comments...

PBIL Back to PBIL home page