(data stored in SCRATCH zone)

SWISSPROT: B7UKV1_ECO27

ID   B7UKV1_ECO27            Unreviewed;       648 AA.
AC   B7UKV1;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 71.
DE   SubName: Full=Fused N-acetyl glucosamine specific PTS enzyme: IIC, IIB, and IIA components {ECO:0000313|EMBL:CAS08109.1};
GN   Name=nagE {ECO:0000313|EMBL:CAS08109.1};
GN   OrderedLocusNames=E2348C_0561 {ECO:0000313|EMBL:CAS08109.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS08109.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS08109.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
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DR   EMBL; FM180568; CAS08109.1; -; Genomic_DNA.
DR   RefSeq; WP_001023115.1; NC_011601.1.
DR   EnsemblBacteria; CAS08109; CAS08109; E2348C_0561.
DR   KEGG; ecg:E2348C_0561; -.
DR   HOGENOM; HOG000250993; -.
DR   KO; K02802; -.
DR   KO; K02803; -.
DR   KO; K02804; -.
DR   OMA; YNRFSHV; -.
DR   BioCyc; ECOL574521:E2348C_RS02975-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019866; C:organelle inner membrane; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015572; F:N-acetylglucosamine transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR   CDD; cd00212; PTS_IIB_glc; 1.
DR   Gene3D; 2.70.70.10; -; 1.
DR   Gene3D; 3.30.1360.60; -; 1.
DR   InterPro; IPR011055; Dup_hybrid_motif.
DR   InterPro; IPR036878; Glu_permease_IIB.
DR   InterPro; IPR018113; PTrfase_EIIB_Cys.
DR   InterPro; IPR001127; PTS_EIIA_1_perm.
DR   InterPro; IPR003352; PTS_EIIC.
DR   InterPro; IPR013013; PTS_EIIC_1.
DR   InterPro; IPR001996; PTS_IIB_1.
DR   InterPro; IPR010974; PTS_IIBC_nag.
DR   Pfam; PF00358; PTS_EIIA_1; 1.
DR   Pfam; PF00367; PTS_EIIB; 1.
DR   Pfam; PF02378; PTS_EIIC; 1.
DR   SUPFAM; SSF51261; SSF51261; 1.
DR   SUPFAM; SSF55604; SSF55604; 1.
DR   TIGRFAMs; TIGR00826; EIIB_glc; 1.
DR   TIGRFAMs; TIGR00830; PTBA; 1.
DR   TIGRFAMs; TIGR01998; PTS-II-BC-nag; 1.
DR   PROSITE; PS51093; PTS_EIIA_TYPE_1; 1.
DR   PROSITE; PS00371; PTS_EIIA_TYPE_1_HIS; 1.
DR   PROSITE; PS51098; PTS_EIIB_TYPE_1; 1.
DR   PROSITE; PS01035; PTS_EIIB_TYPE_1_CYS; 1.
DR   PROSITE; PS51103; PTS_EIIC_TYPE_1; 1.
PE   4: Predicted;
DR   PRODOM; B7UKV1.
DR   SWISS-2DPAGE; B7UKV1.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00467886};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   Kinase {ECO:0000256|SAAS:SAAS00737055};
KW   Membrane {ECO:0000256|SAAS:SAAS00468091, ECO:0000256|SAM:Phobius};
KW   Phosphotransferase system {ECO:0000256|SAAS:SAAS00467990};
KW   Sugar transport {ECO:0000256|SAAS:SAAS00103093};
KW   Transferase {ECO:0000256|SAAS:SAAS00472891};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00467970,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00468233,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00468113}.
FT   TRANSMEM     38     61       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     68     88       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     94    112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    132    153       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    165    185       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    192    212       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    232    252       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    259    276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    282    306       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    337    359       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    371       PTS EIIC type-1. {ECO:0000259|PROSITE:
FT                                PS51103}.
FT   DOMAIN      390    472       PTS EIIB type-1. {ECO:0000259|PROSITE:
FT                                PS51098}.
FT   DOMAIN      517    621       PTS EIIA type-1. {ECO:0000259|PROSITE:
FT                                PS51093}.
FT   ACT_SITE    412    412       Phosphocysteine intermediate; for EIIB
FT                                activity. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00421}.
SQ   SEQUENCE   648 AA;  68330 MW;  1AE701C917A23186 CRC64;
     MNILGFFQRL GRALQLPIAV LPVAALLLRF GQPDLLNVAF IAQAGGAIFD NLALIFAIGV
     ASSWSKDSAG AAALAGAVGY FVLTKAMVTI NPEINMGVLA GIITGLVGGA AYNRWSDIKL
     PDFLSFFGGK RFVPIATGFF CLVLAAIFGY VWPPVQHAIH AGGEWIVSAG ALGSGIFGFI
     NRLLIPTGLH QVLNTIAWFQ IGEFTNAAGT VFHGDINRFY AGDGTAGMFM SGFFPIMMFG
     LPGAALAMYF AAPKERRPMV GGMLLSVAVT AFLTGVTEPL EFLFMFLAPL LYLLHALLTG
     ISLFVATLLG IHAGFSFSAG AIDYALMYNL PAASQNVWML LVMGVVFFAI YFVVFSLVIR
     MFNLKTPGRE DKEDEIVTEE ANSNTEEGLN QLATNYIAAV GGTDNLKAID ACITRLRLTV
     VDSARVNDAM CKRLGASGVV KLNKQTIQVI VGAKAESIGD AMKKVVARGP VAAASAEATP
     ATAAPVAKPQ AVPNAVSIAE LVSPITGDVV ALDQVPDEAF ASKAVGDGVA VKPTDKIVVS
     PAAGTIVKIF NTNHAFCLET EKGAEIVVHM GIDTVALEGK GFKRLVEEGA QVSAGQPILE
     MDLDYLNANA RSMISPVVCS NIDDFSGLII KAQGHVVAGQ TPLYEIKK
//

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