(data stored in SCRATCH zone)

SWISSPROT: B7ULM5_ECO27

ID   B7ULM5_ECO27            Unreviewed;       313 AA.
AC   B7ULM5;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   05-DEC-2018, entry version 57.
DE   RecName: Full=Zinc transporter ZitB {ECO:0000256|HAMAP-Rule:MF_00552};
GN   Name=zitB {ECO:0000256|HAMAP-Rule:MF_00552,
GN   ECO:0000313|EMBL:CAS08177.1};
GN   OrderedLocusNames=E2348C_0629 {ECO:0000313|EMBL:CAS08177.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS08177.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS08177.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- FUNCTION: Involved in zinc efflux across the cytoplasmic membrane,
CC       thus reducing zinc accumulation in the cytoplasm and rendering
CC       bacteria more resistant to zinc. It may contribute to zinc
CC       homeostasis at low concentrations of zinc. {ECO:0000256|HAMAP-
CC       Rule:MF_00552}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_00552}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_00552}.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. SLC30A subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00552}.
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DR   EMBL; FM180568; CAS08177.1; -; Genomic_DNA.
DR   RefSeq; WP_000951278.1; NC_011601.1.
DR   EnsemblBacteria; CAS08177; CAS08177; E2348C_0629.
DR   KEGG; ecg:E2348C_0629; -.
DR   HOGENOM; HOG000079021; -.
DR   KO; K16264; -.
DR   OMA; RTWGWAR; -.
DR   BioCyc; ECOL574521:E2348C_RS03375-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   HAMAP; MF_00552; ZitB; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   InterPro; IPR023500; Zn_transptr_ZitB.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF160240; SSF160240; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   TIGRFAMs; TIGR01297; CDF; 1.
PE   3: Inferred from homology;
DR   PRODOM; B7ULM5.
DR   SWISS-2DPAGE; B7ULM5.
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00552};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_00552};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   Ion transport {ECO:0000256|HAMAP-Rule:MF_00552};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_00552};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_00552};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00552};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_00552};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00552};
KW   Zinc transport {ECO:0000256|HAMAP-Rule:MF_00552}.
FT   TRANSMEM     21     41       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00552}.
FT   TRANSMEM     47     68       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00552}.
FT   TRANSMEM     89    110       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00552}.
FT   TRANSMEM    122    143       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00552}.
FT   TRANSMEM    155    182       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00552}.
SQ   SEQUENCE   313 AA;  34720 MW;  3B3DCB7CEF6E2297 CRC64;
     MAHSHSHTSS HLPEDNNARR LLYAFGVTAG FMLVEVIGGF LSGSLALLAD AGHMLTDTAA
     LLFALLAVQF SRRPPTIRHT FGWLRLTTLA AFVNAIALVV ITILIVWEAI ERFRTPRPVE
     GGMMMAIAVA GLLANILSFW LLHHGSEEKN LNVRAAALHV LGDLLGSVGA IIAALIIIWT
     GWTPADPILS ILVSLLVLRS AWRLLKDSVN ELLEGAPVSL DIAELKRRMC REIPEVRNVH
     HVHVWMVGEK PVMTLHVQVI PPHDHDALLD QIQHYLMDHY QIEHATIQME YQPCHGPDCH
     LNRGVSGHSH HHH
//

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