(data stored in SCRATCH zone)

SWISSPROT: B8IT22_METNO

ID   B8IT22_METNO            Unreviewed;       737 AA.
AC   B8IT22;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   05-JUL-2017, entry version 55.
DE   SubName: Full=(P)ppGpp synthetase I, SpoT/RelA {ECO:0000313|EMBL:ACL55084.1};
DE            EC=2.7.6.5 {ECO:0000313|EMBL:ACL55084.1};
GN   OrderedLocusNames=Mnod_0033 {ECO:0000313|EMBL:ACL55084.1};
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL55084.1, ECO:0000313|Proteomes:UP000008207};
RN   [1] {ECO:0000313|EMBL:ACL55084.1, ECO:0000313|Proteomes:UP000008207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC   {ECO:0000313|Proteomes:UP000008207};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium nodulans ORS
RT   2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5-'
CC       diphosphate) is a mediator of the stringent response that
CC       coordinates a variety of cellular activities in response to
CC       changes in nutritional abundance. {ECO:0000256|RuleBase:RU003847}.
CC   -!- SIMILARITY: Belongs to the relA/spoT family.
CC       {ECO:0000256|RuleBase:RU003847}.
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DR   EMBL; CP001349; ACL55084.1; -; Genomic_DNA.
DR   RefSeq; WP_012634323.1; NC_011894.1.
DR   ProteinModelPortal; B8IT22; -.
DR   STRING; 460265.Mnod_0033; -.
DR   EnsemblBacteria; ACL55084; ACL55084; Mnod_0033.
DR   KEGG; mno:Mnod_0033; -.
DR   eggNOG; ENOG4105CWR; Bacteria.
DR   eggNOG; COG0317; LUCA.
DR   HOGENOM; HOG000018299; -.
DR   KO; K00951; -.
DR   OMA; HYYSIYQ; -.
DR   OrthoDB; POG091H01YD; -.
DR   Proteomes; UP000008207; Chromosome.
DR   GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   CDD; cd01668; TGS_RelA_SpoT; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR012675; Beta-grasp_dom.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR004811; RelA/Spo_fam.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR033655; TGS_RelA.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF81271; SSF81271; 1.
DR   TIGRFAMs; TIGR00691; spoT_relA; 1.
DR   PROSITE; PS51671; ACT; 1.
PE   3: Inferred from homology;
DR   PRODOM; B8IT22.
DR   SWISS-2DPAGE; B8IT22.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008207};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008207};
KW   Transferase {ECO:0000313|EMBL:ACL55084.1}.
FT   DOMAIN      663    737       ACT. {ECO:0000259|PROSITE:PS51671}.
SQ   SEQUENCE   737 AA;  82037 MW;  DE0AC346D7F88330 CRC64;
     MMRQYELVER VKAYNPAADE AMLNRAYVYA MRAHGSQMRA SGDLFFAHPL EVAAILTELR
     VDDATIVAAV LHDTVEDTAA TLEEINRTFT PEIGTLVDGL TKIKRLDLVS KQAAQGENFR
     KLLLAIAADV RVLLVKLADR LHNMRTLHHM PPEKRVRIAQ ETLDIYAPLA GRMGMQELRE
     ELEDLSFRNL KPDVYATISK RLDDLTTKSE SLVESIERDL VQRLAAKGIT AQVRGRQKRP
     YSIWSKMERK SVAFEQLSDI FGFRVVVDSV DTCYRALGVV HTTWPMVPGR YKDYISTPKQ
     NDYRSIHTTV IGPKSQRVEL QIRTAEMDEV AEYGIAAHAL YKDGSPHLAT ESGAYQWLRR
     TIELLAEGDS PEEFLEHTKL ELFQDQVFCF TPKGRLIALP RGATPIDFAY AVHTELGNAA
     VGAKINGRIA PLLTELQNGD EVEIVRADGQ TPPAAWESLV VTGKARAAIR RATRSAVRRQ
     YAGLGRQILD RAFERAGKNF SDEKLRGALP RLARTSAEDV FAAVGRGEMF SGDVVKAVYP
     DYKDERRSQS AATGPKPHVN GAGRLSLDKD QTVRLTWPGK GRGEEDEGAI PIRGLDRDLP
     VRFAPEGGAV PGDRIVGILT PGEGVTIYPI QSPALAAFDN EPDRWLDVRW DVDGGSNQRF
     PARIALQSIN EPGSFAQIAQ VIADHDGNID NISMKRRSQD FTDVLIDLSV WDLKHLNAIV
     SELRAKRVVS RVERVNG
//

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