(data stored in SCRATCH zone)

SWISSPROT: B8IU64_METNO

ID   B8IU64_METNO            Unreviewed;       461 AA.
AC   B8IU64;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   08-MAY-2019, entry version 73.
DE   SubName: Full=Histidine kinase {ECO:0000313|EMBL:ACL55109.1};
GN   OrderedLocusNames=Mnod_0058 {ECO:0000313|EMBL:ACL55109.1};
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL55109.1, ECO:0000313|Proteomes:UP000008207};
RN   [1] {ECO:0000313|EMBL:ACL55109.1, ECO:0000313|Proteomes:UP000008207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC   {ECO:0000313|Proteomes:UP000008207};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium nodulans ORS
RT   2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; CP001349; ACL55109.1; -; Genomic_DNA.
DR   RefSeq; WP_012634348.1; NC_011894.1.
DR   STRING; 460265.Mnod_0058; -.
DR   EnsemblBacteria; ACL55109; ACL55109; Mnod_0058.
DR   KEGG; mno:Mnod_0058; -.
DR   eggNOG; ENOG4105DAU; Bacteria.
DR   eggNOG; COG0642; LUCA.
DR   HOGENOM; HOG000223178; -.
DR   KO; K07649; -.
DR   OMA; NHAMVIH; -.
DR   OrthoDB; 692375at2; -.
DR   BioCyc; MNOD460265:GCZK-58-MONOMER; -.
DR   Proteomes; UP000008207; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR013727; 2CSK_N.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF08521; 2CSK_N; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; B8IU64.
DR   SWISS-2DPAGE; B8IU64.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008207};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:ACL55109.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008207};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM    168    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      188    239       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      247    458       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   461 AA;  48899 MW;  CC4F2ACBA4220989 CRC64;
     MIGRTPSLFL RLVTVLGLVL AVGAALLLGA AWTSARLAAD QAYDRLLVGA ALQIAETIAS
     DGREITVDPP FSAFETLGLA PRDRIFYKVV DPSDGLLTGS PDLAVPVDRA RLGDGPLLLD
     ATHRGEPVRV VVAGRYVPDI PKAGWAAVVV AQTREARNGL AGDLTAKASL LVLTMSALAL
     GAVTVAVRAA LRPLAALERV LAGRGPNDLD PLDLAVPREI HLLVTSINHF MDRLSGHMAI
     MRRFIADAAH QIRTPLAALG AQVDLLSAEG DEARRREQVI RVQERTAELG RLTNQLLNHA
     MVIHRARSIP LAPVDLGAIA RRTLIDAIPL AGTRPIDFGY EGPDEPLPIR GDPIALREAL
     ANLIHNGIKH GAPGRLTVRT RRERDRITVE VVDDGAGIPA AEWRRVREPF QAASGGAIGS
     GLGLAIAAEV TAAHGGEMRF ESRSDEGFAV LLSFPAAEAA P
//

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