(data stored in SCRATCH zone)

SWISSPROT: YRKA_BACSU

ID   YRKA_BACSU              Reviewed;         434 AA.
AC   P54428; O07087;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   11-DEC-2019, entry version 131.
DE   RecName: Full=UPF0053 protein YrkA;
GN   Name=yrkA; OrderedLocusNames=BSU26610;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9308178; DOI=10.1099/00221287-143-9-2939;
RA   Sorokin A., Bolotin A., Purnelle B., Hilbert H., Lauber J.,
RA   Duesterhoeft A., Ehrlich S.D.;
RT   "Sequence of the Bacillus subtilis genome region in the vicinity of the lev
RT   operon reveals two new extracytoplasmic function RNA polymerase sigma
RT   factors SigV and SigZ.";
RL   Microbiology 143:2939-2943(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 218-434.
RC   STRAIN=168 / JH642;
RX   PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA   Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA   Kobayashi Y.;
RT   "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT   Bacillus subtilis genome containing the skin element and many sporulation
RT   genes.";
RL   Microbiology 142:3103-3111(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 261-434.
RC   STRAIN=168 / BD170;
RX   PubMed=7608059; DOI=10.1128/jb.177.14.3904-3910.1995;
RA   Ahmed M., Lyass L., Markham P.N., Taylor S.S., Vazquez-Laslop N.,
RA   Neyfakh A.A.;
RT   "Two highly similar multidrug transporters of Bacillus subtilis whose
RT   expression is differentially regulated.";
RL   J. Bacteriol. 177:3904-3910(1995).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
DR   EMBL; U93876; AAB80911.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14602.1; -; Genomic_DNA.
DR   EMBL; D84432; BAA12353.1; -; Genomic_DNA.
DR   EMBL; L32599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; G69975; G69975.
DR   RefSeq; NP_390538.1; NC_000964.3.
DR   RefSeq; WP_003246022.1; NZ_JNCM01000036.1.
DR   SMR; P54428; -.
DR   STRING; 224308.BSU26610; -.
DR   TCDB; 1.A.112.2.2; the cyclin m mg2+ exporter (cnnm) family.
DR   PaxDb; P54428; -.
DR   PRIDE; P54428; -.
DR   DNASU; 937634; -.
DR   EnsemblBacteria; CAB14602; CAB14602; BSU26610.
DR   GeneID; 937634; -.
DR   KEGG; bsu:BSU26610; -.
DR   PATRIC; fig|224308.179.peg.2891; -.
DR   eggNOG; ENOG4105C37; Bacteria.
DR   eggNOG; COG1253; LUCA.
DR   HOGENOM; HOG000062295; -.
DR   InParanoid; P54428; -.
DR   OMA; YSMMEMA; -.
DR   PhylomeDB; P54428; -.
DR   BioCyc; BSUB:BSU26610-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   Pfam; PF01595; DUF21; 1.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   3: Inferred from homology;
DR   PRODOM; P54428.
DR   SWISS-2DPAGE; P54428.
KW   CBS domain; Cell membrane; Membrane; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..434
FT                   /note="UPF0053 protein YrkA"
FT                   /id="PRO_0000088373"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..201
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT   DOMAIN          220..282
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          289..346
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   CONFLICT        218..225
FT                   /note="EIMIPRRE -> VDLQVNGS (in Ref. 3)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        270
FT                   /note="L -> W (in Ref. 4)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        276
FT                   /note="T -> P (in Ref. 4)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        307
FT                   /note="V -> G (in Ref. 4)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        310
FT                   /note="Q -> R (in Ref. 4)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   434 AA;  48985 MW;  F63296CB37043B3D CRC64;
     MTTINLIIFT LLIVLTAFFV ATEFAIVKIR SSKIDQLILE GKKGAISAKK VITHLDEYLS
     ACQLGITVTA LGIGWVGEST FEVILHPLFA HFHVSETVSH VLILVIAFVM ATFLHVVVGE
     LAPKTLAIQK AETITLLTAK PIIWFYRILF PFIWFLNGSA RFIVGLFGLK PASEHELAHS
     EEELRILLSE SYKSGEINQN ELKYVNNIFE FDERIAKEIM IPRREIVAIS SEDSYETIVK
     IIKTESYTRY PVLNGDKDSI IGFINAKEFL SAYIDTDQKI KEDFKLENHI NPVIHVIESV
     PIHDVLVKMQ KERTHIAILV DEYGGTSGLV TAEDILEEIV GEIRDEFDKD EVPNIRKVND
     NHYILDSKVL IEDVNDLLGT TLASDEVDTI GGWFMTQQID AAVGSVIEAD GYIFKVHETV
     GRHINYLEIV RKKE
//

If you have problems or comments...

PBIL Back to PBIL home page