(data stored in SCRATCH zone)

SWISSPROT: YQCF_BACSU

ID   YQCF_BACSU              Reviewed;         192 AA.
AC   P45941;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   11-DEC-2019, entry version 91.
DE   RecName: Full=Antitoxin YqcF;
GN   Name=yqcF; OrderedLocusNames=BSU25870;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RX   PubMed=7704261; DOI=10.1099/13500872-141-2-323;
RA   Takemaru K., Mizuno M., Sato T., Takeuchi M., Kobayashi Y.;
RT   "Complete nucleotide sequence of a skin element excised by DNA
RT   rearrangement during sporulation in Bacillus subtilis.";
RL   Microbiology 141:323-327(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RX   PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA   Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA   Kobayashi Y.;
RT   "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT   Bacillus subtilis genome containing the skin element and many sporulation
RT   genes.";
RL   Microbiology 142:3103-3111(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=7489895; DOI=10.1016/0378-1119(95)00636-k;
RA   Medigue C., Moszer I., Viari A., Danchin A.;
RT   "Analysis of a Bacillus subtilis genome fragment using a co-operative
RT   computer system prototype.";
RL   Gene 165:GC37-GC51(1995).
RN   [5]
RP   FUNCTION AS AN ANTITOXIN, AND EXPRESSION IN E.COLI.
RX   PubMed=22200572; DOI=10.1016/j.febslet.2011.12.020;
RA   Holberger L.E., Garza-Sanchez F., Lamoureux J., Low D.A., Hayes C.S.;
RT   "A novel family of toxin/antitoxin proteins in Bacillus species.";
RL   FEBS Lett. 586:132-136(2012).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Neutralizes the RNase activity of cognate toxin YqcG, as well as its
CC       ability to inhibit growth upon expression in E.coli. Does not have
CC       antitoxin activity on other toxins with the LXG toxin domain.
CC       {ECO:0000269|PubMed:22200572}.
CC   -!- SUBUNIT: Probably interacts with cognate toxin YqcG but not with other
CC       non-cognate toxins. The interaction inhibits the toxic activity of YqcG
CC       (Probable). {ECO:0000305}.
DR   EMBL; D32216; BAA06963.1; -; Genomic_DNA.
DR   EMBL; D84432; BAA12427.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14528.1; -; Genomic_DNA.
DR   PIR; E69949; E69949.
DR   RefSeq; NP_390464.1; NC_000964.3.
DR   RefSeq; WP_009967790.1; NZ_JNCM01000036.1.
DR   STRING; 224308.BSU25870; -.
DR   PaxDb; P45941; -.
DR   PRIDE; P45941; -.
DR   EnsemblBacteria; CAB14528; CAB14528; BSU25870.
DR   GeneID; 937785; -.
DR   KEGG; bsu:BSU25870; -.
DR   PATRIC; fig|224308.179.peg.2811; -.
DR   eggNOG; ENOG41064HX; Bacteria.
DR   eggNOG; ENOG41121YC; LUCA.
DR   HOGENOM; HOG000026322; -.
DR   InParanoid; P45941; -.
DR   KO; K21492; -.
DR   OMA; GSDVMGK; -.
DR   BioCyc; BSUB:BSU25870-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   InterPro; IPR020941; SUFU-like_domain.
DR   Pfam; PF05076; SUFU; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P45941.
DR   SWISS-2DPAGE; P45941.
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..192
FT                   /note="Antitoxin YqcF"
FT                   /id="PRO_0000049776"
SQ   SEQUENCE   192 AA;  21476 MW;  56210B4C7405BBB8 CRC64;
     MGVTQENKVI ARTVLGAFGG KPKVTKYWDD NKNSSIDILS VSDQPQEGIT SYSTLGLSDH
     SINYEVNGTP LRIEIVAAME SASDIYANVL STCAFNIINS NFTCAPGVIF KNVISMYDQE
     TDMKHIMFVP PFLWEEDLEL LEFSNKNVTW LMALPISEGE LQVAEKHGSD YLQDLLESKQ
     IDIFDIKRES VV
//

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