(data stored in SCRATCH zone)

SWISSPROT: YQEC_BACSU

ID   YQEC_BACSU              Reviewed;         297 AA.
AC   P54448;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   11-DEC-2019, entry version 137.
DE   RecName: Full=Putative 6-phosphogluconate dehydrogenase YqeC;
DE            EC=1.1.1.-;
GN   Name=yqeC; OrderedLocusNames=BSU25730;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RX   PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA   Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA   Kobayashi Y.;
RT   "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT   Bacillus subtilis genome containing the skin element and many sporulation
RT   genes.";
RL   Microbiology 142:3103-3111(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   PROPOSED FUNCTION.
RX   PubMed=15231785; DOI=10.1128/jb.186.14.4528-4534.2004;
RA   Zamboni N., Fischer E., Laudert D., Aymerich S., Hohmann H.P., Sauer U.;
RT   "The Bacillus subtilis yqjI gene encodes the NADP+-dependent 6-P-gluconate
RT   dehydrogenase in the pentose phosphate pathway.";
RL   J. Bacteriol. 186:4528-4534(2004).
CC   -!- FUNCTION: May act as NAD-dependent 6-P-gluconate dehydrogenase.
CC   -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase family.
CC       {ECO:0000305}.
DR   EMBL; D84432; BAA12439.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14514.1; -; Genomic_DNA.
DR   PIR; G69950; G69950.
DR   RefSeq; NP_390450.1; NC_000964.3.
DR   RefSeq; WP_003229961.1; NZ_JNCM01000036.1.
DR   SMR; P54448; -.
DR   STRING; 224308.BSU25730; -.
DR   PaxDb; P54448; -.
DR   PRIDE; P54448; -.
DR   EnsemblBacteria; CAB14514; CAB14514; BSU25730.
DR   GeneID; 937809; -.
DR   KEGG; bsu:BSU25730; -.
DR   PATRIC; fig|224308.179.peg.2798; -.
DR   eggNOG; COG1023; LUCA.
DR   HOGENOM; HOG000255146; -.
DR   InParanoid; P54448; -.
DR   KO; K00033; -.
DR   OMA; NGYALMY; -.
DR   PhylomeDB; P54448; -.
DR   BioCyc; BSUB:BSU25730-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro.
DR   GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR004849; 6DGDH_YqeC.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006114; 6PGDH_C.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR006184; 6PGdom_BS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006183; Pgluconate_DH.
DR   PANTHER; PTHR11811; PTHR11811; 1.
DR   Pfam; PF00393; 6PGD; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PRINTS; PR00076; 6PGDHDRGNASE.
DR   SMART; SM01350; 6PGD; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00872; gnd_rel; 1.
DR   PROSITE; PS00461; 6PGD; 1.
PE   3: Inferred from homology;
DR   PRODOM; P54448.
DR   SWISS-2DPAGE; P54448.
KW   Gluconate utilization; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..297
FT                   /note="Putative 6-phosphogluconate dehydrogenase YqeC"
FT                   /id="PRO_0000090077"
FT   NP_BIND         7..12
FT                   /note="NAD"
FT                   /evidence="ECO:0000250"
FT   REGION          120..122
FT                   /note="Substrate binding"
FT                   /evidence="ECO:0000250"
FT   REGION          173..174
FT                   /note="Substrate binding"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        170
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        177
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         94
FT                   /note="NAD"
FT                   /evidence="ECO:0000250"
FT   BINDING         94
FT                   /note="Substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         178
FT                   /note="Substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         268
FT                   /note="Substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   297 AA;  32769 MW;  83607681471AC73C CRC64;
     MKIGLIGLGK MGINIGKQFI DRNHQVVGYD VNQAAVDELK AYGAEGTTNL KEFISLLHPP
     RILWVMVPHG IVDAVLRDVS PLLSKGDMII EAGNSHYKES IRRYNQMKEA GIHYLDAGTS
     GGMEGARHGA CFMVGGDHEA WEIVEPLFRD TAVENGYLYA GEAGSGHFLK MIHNGIEYGM
     MAAIGEGFEV LENSQFDFDY EKVARVWNHG SVIRSWLMGL TERAFAKDAK LDQIKGIMHS
     SGEGKWTVET ALDLQTATPV IAMSLMMRYR SLTDDTFTGK VVAALRNEFG GHATEKK
//

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