(data stored in SCRATCH zone)

SWISSPROT: YQEH_BACSU

ID   YQEH_BACSU              Reviewed;         366 AA.
AC   P54453;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   11-DEC-2019, entry version 113.
DE   RecName: Full=Uncharacterized protein YqeH;
GN   Name=yqeH; OrderedLocusNames=BSU25670;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RX   PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA   Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA   Kobayashi Y.;
RT   "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT   Bacillus subtilis genome containing the skin element and many sporulation
RT   genes.";
RL   Microbiology 142:3103-3111(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   GTP- AND GDP-BINDING, PROTEIN LEVELS, AND DISRUPTION PHENOTYPE.
RC   STRAIN=CRK6000;
RX   PubMed=12427945; DOI=10.1099/00221287-148-11-3539;
RA   Morimoto T., Loh P.C., Hirai T., Asai K., Kobayashi K., Moriya S.,
RA   Ogasawara N.;
RT   "Six GTP-binding proteins of the Era/Obg family are essential for cell
RT   growth in Bacillus subtilis.";
RL   Microbiology 148:3539-3552(2002).
CC   -!- FUNCTION: Binds GTP and GDP.
CC   -!- DISRUPTION PHENOTYPE: Essential for growth, it cannot be disrupted. In
CC       depletion experiments cells become 1.5 to 2-fold longer and nucleoid
CC       distribution is dispersed. The number of replication origins increases,
CC       suggesting an increase in chromosome replication.
CC       {ECO:0000269|PubMed:12427945}.
CC   -!- MISCELLANEOUS: Estimated to be present at 2000 copies per cell.
CC   -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01058}.
DR   EMBL; D84432; BAA12444.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14509.1; -; Genomic_DNA.
DR   PIR; D69951; D69951.
DR   RefSeq; NP_390445.1; NC_000964.3.
DR   RefSeq; WP_003229966.1; NZ_JNCM01000036.1.
DR   SMR; P54453; -.
DR   STRING; 224308.BSU25670; -.
DR   PaxDb; P54453; -.
DR   PRIDE; P54453; -.
DR   EnsemblBacteria; CAB14509; CAB14509; BSU25670.
DR   GeneID; 937822; -.
DR   KEGG; bsu:BSU25670; -.
DR   PATRIC; fig|224308.179.peg.2790; -.
DR   eggNOG; ENOG4105CQW; Bacteria.
DR   eggNOG; COG1161; LUCA.
DR   HOGENOM; HOG000016390; -.
DR   InParanoid; P54453; -.
DR   KO; K06948; -.
DR   OMA; HYNEVQD; -.
DR   PhylomeDB; P54453; -.
DR   BioCyc; BSUB:BSU25670-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0032297; P:negative regulation of DNA-dependent DNA replication initiation; IDA:CACAO.
DR   InterPro; IPR030378; G_CP_dom.
DR   InterPro; IPR019988; GTP-bd_ribosome_bgen_YqeH.
DR   InterPro; IPR006073; GTP_binding_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03597; GTPase_YqeH; 1.
DR   PROSITE; PS51721; G_CP; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P54453.
DR   SWISS-2DPAGE; P54453.
KW   GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..366
FT                   /note="Uncharacterized protein YqeH"
FT                   /id="PRO_0000049785"
FT   DOMAIN          59..222
FT                   /note="CP-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
SQ   SEQUENCE   366 AA;  40999 MW;  6B2D47FA2FEEBA10 CRC64;
     MEKVVCIGCG VTIQTEDKTG LGYAPPASLT KENVICQRCF RLKNYNEIQD VSLTDDDFLN
     ILHGIGETDS LVVKIVDIFD FNGSWINGLQ RLVGGNPILL VGNKADILPK SLKRERLIQW
     MKREAKELGL KPVDVFLVSA GRGQGIREVI DAIEHYRNGK DVYVVGCTNV GKSTFINRII
     KEVSGEEDII TTSQFPGTTL DAIEIPLDDG SSLYDTPGII NNHQMAHYVN KKDLKILSPK
     KELKPRTFQL NDQQTLYFGG LARFDYVSGE RSPFICYMPN ELMIHRTKLE NADALYEKHA
     GELLTPPGKD EMDEFPELVA HTFTIKDKKT DIVFSGLGWV TVHDADKKVT AYAPKGVHVF
     VRRSLI
//

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