(data stored in SCRATCH zone)

SWISSPROT: GCH1L_BACSU

ID   GCH1L_BACSU             Reviewed;         373 AA.
AC   P54472; O32024;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 2.
DT   11-DEC-2019, entry version 112.
DE   RecName: Full=GTP cyclohydrolase 1 type 2 homolog;
GN   Name=yqfO; OrderedLocusNames=BSU25170;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RX   PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA   Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA   Kobayashi Y.;
RT   "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT   Bacillus subtilis genome containing the skin element and many sporulation
RT   genes.";
RL   Microbiology 142:3103-3111(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- SUBUNIT: Homohexamer. {ECO:0000250|UniProtKB:P0AFP6}.
CC   -!- SIMILARITY: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA12492.1; Type=Frameshift; Evidence={ECO:0000305};
DR   EMBL; D84432; BAA12492.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AL009126; CAB14447.1; -; Genomic_DNA.
DR   PIR; A69954; A69954.
DR   RefSeq; NP_390396.1; NC_000964.3.
DR   RefSeq; WP_004399125.1; NZ_JNCM01000036.1.
DR   SMR; P54472; -.
DR   STRING; 224308.BSU25170; -.
DR   jPOST; P54472; -.
DR   PaxDb; P54472; -.
DR   PRIDE; P54472; -.
DR   EnsemblBacteria; CAB14447; CAB14447; BSU25170.
DR   GeneID; 937901; -.
DR   KEGG; bsu:BSU25170; -.
DR   PATRIC; fig|224308.179.peg.2736; -.
DR   eggNOG; ENOG4105EGD; Bacteria.
DR   eggNOG; COG0327; LUCA.
DR   eggNOG; COG3323; LUCA.
DR   HOGENOM; HOG000014257; -.
DR   InParanoid; P54472; -.
DR   OMA; HWATEWP; -.
DR   PhylomeDB; P54472; -.
DR   BioCyc; BSUB:BSU25170-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.120; -; 1.
DR   InterPro; IPR002678; GTP_cyclohydrolase_I/Nif3.
DR   InterPro; IPR036069; GTP_cyclohydrolase_I/Nif3_sf.
DR   InterPro; IPR017221; GTP_cyclohydrolase_I_bac.
DR   InterPro; IPR015867; N-reg_PII/ATP_PRibTrfase_C.
DR   PANTHER; PTHR13799; PTHR13799; 1.
DR   Pfam; PF01784; NIF3; 1.
DR   PIRSF; PIRSF037489; UCP037489_NIF3_YqfO; 1.
DR   SUPFAM; SSF102705; SSF102705; 1.
DR   TIGRFAMs; TIGR00486; YbgI_SA1388; 1.
PE   3: Inferred from homology;
DR   PRODOM; P54472.
DR   SWISS-2DPAGE; P54472.
KW   Metal-binding; Reference proteome.
FT   CHAIN           1..373
FT                   /note="GTP cyclohydrolase 1 type 2 homolog"
FT                   /id="PRO_0000147295"
FT   METAL           68
FT                   /note="Divalent metal cation 1"
FT                   /evidence="ECO:0000250|UniProtKB:P0AFP6"
FT   METAL           69
FT                   /note="Divalent metal cation 2"
FT                   /evidence="ECO:0000250|UniProtKB:P0AFP6"
FT   METAL           107
FT                   /note="Divalent metal cation 1"
FT                   /evidence="ECO:0000250|UniProtKB:P0AFP6"
FT   METAL           333
FT                   /note="Divalent metal cation 2"
FT                   /evidence="ECO:0000250|UniProtKB:P0AFP6"
FT   METAL           336
FT                   /note="Divalent metal cation 1"
FT                   /evidence="ECO:0000250|UniProtKB:P0AFP6"
FT   METAL           336
FT                   /note="Divalent metal cation 2"
FT                   /evidence="ECO:0000250|UniProtKB:P0AFP6"
FT   CONFLICT        265..266
FT                   /note="KD -> FC (in Ref. 1; BAA12492)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   373 AA;  40920 MW;  E2320C1268D8BE9B CRC64;
     MAKSVNGQQI IQLFEQFSPK AYAVEGDKIG LQIGTLNKPI KNVMVTLDVL ESVIDEAIEK
     EVDLIIAHHP PIFRSLKHIS TDQPAGRLIE KCLKHDIAVY AAHTNLDVAD GGVNDLLAEA
     LELSETEVLA PTYTDPLKKL AVYVPKEYEE QVRAALGNAG AGHIGEYSHC AFSSEGIGSF
     KPLDGAKPFI GEVGELELVH EVRLETVFPK SVEKAVINAM IKSHPYEEVA YDIYPVEQTP
     AEKGLGRVGT LKNEMTLKEF ALFVKDKLDV NGVRMVGDAD SMVKKVAVLG GDGNKYIHHA
     KRKGADVYVT GDLYFHVAHD AMMLGLNVVD PGHYAEKIMK EGVTRKLTSM CNDKKFGVNI
     FVSETDTNPF TFL
//

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