(data stored in SCRATCH zone)

SWISSPROT: MGSR_BACSU

ID   MGSR_BACSU              Reviewed;         126 AA.
AC   P54503;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   11-DEC-2019, entry version 118.
DE   RecName: Full=Regulatory protein MgsR;
DE   AltName: Full=Modulator of the general stress response;
GN   Name=mgsR; Synonyms=yqgZ; OrderedLocusNames=BSU24770;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RX   PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA   Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA   Kobayashi Y.;
RT   "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT   Bacillus subtilis genome containing the skin element and many sporulation
RT   genes.";
RL   Microbiology 142:3103-3111(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 77.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   INDUCTION.
RX   PubMed=11544224; DOI=10.1128/jb.183.19.5617-5631.2001;
RA   Petersohn A., Brigulla M., Haas S., Hoheisel J.D., Voelker U., Hecker M.;
RT   "Global analysis of the general stress response of Bacillus subtilis.";
RL   J. Bacteriol. 183:5617-5631(2001).
RN   [5]
RP   FUNCTION, INDUCTION, MUTAGENESIS OF CYS-13 AND GLY-55, AND GENE NAME.
RX   PubMed=18643936; DOI=10.1111/j.1365-2958.2008.06332.x;
RA   Reder A., Hoper D., Weinberg C., Gerth U., Fraunholz M., Hecker M.;
RT   "The Spx paralogue MgsR (YqgZ) controls a subregulon within the general
RT   stress response of Bacillus subtilis.";
RL   Mol. Microbiol. 69:1104-1120(2008).
CC   -!- FUNCTION: Regulates transcription of a subregulon within the general
CC       stress response. Exerts positive and negative effects in response to
CC       ethanol stress. {ECO:0000269|PubMed:18643936}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Expression is sigma B-dependent. Induced by ethanol, heat
CC       and salt stress. {ECO:0000269|PubMed:11544224,
CC       ECO:0000269|PubMed:18643936}.
CC   -!- SIMILARITY: Belongs to the ArsC family. {ECO:0000305}.
DR   EMBL; D84432; BAA12529.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14408.2; -; Genomic_DNA.
DR   PIR; C69958; C69958.
DR   RefSeq; NP_390357.2; NC_000964.3.
DR   RefSeq; WP_003230147.1; NZ_JNCM01000036.1.
DR   SMR; P54503; -.
DR   STRING; 224308.BSU24770; -.
DR   PaxDb; P54503; -.
DR   PRIDE; P54503; -.
DR   EnsemblBacteria; CAB14408; CAB14408; BSU24770.
DR   GeneID; 938484; -.
DR   KEGG; bsu:BSU24770; -.
DR   PATRIC; fig|224308.179.peg.2696; -.
DR   eggNOG; COG1393; LUCA.
DR   HOGENOM; HOG000059715; -.
DR   InParanoid; P54503; -.
DR   KO; K00537; -.
DR   OMA; RMFIPRE; -.
DR   PhylomeDB; P54503; -.
DR   BioCyc; BSUB:BSU24770-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.30.10; -; 1.
DR   InterPro; IPR006660; Arsenate_reductase-like.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR006504; Tscrpt_reg_Spx/MgsR.
DR   Pfam; PF03960; ArsC; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR01617; arsC_related; 1.
DR   PROSITE; PS51353; ARSC; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P54503.
DR   SWISS-2DPAGE; P54503.
KW   Activator; Cytoplasm; Reference proteome; Repressor; Stress response;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..126
FT                   /note="Regulatory protein MgsR"
FT                   /id="PRO_0000162583"
FT   MUTAGEN         13
FT                   /note="C->S: Loss of activity."
FT                   /evidence="ECO:0000269|PubMed:18643936"
FT   MUTAGEN         55
FT                   /note="G->R: Loss of activity."
FT                   /evidence="ECO:0000269|PubMed:18643936"
FT   CONFLICT        77
FT                   /note="M -> I (in Ref. 1; BAA12529)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   126 AA;  14842 MW;  AD1556A2B10DE10E CRC64;
     MEQQLTFYSY PSCTSCRKTK HWLKAHQIEF NERHLFRETP TREELKYILS LTTEGIDEIL
     ATRSQTFKNL NLNIEEMTVN EVLELLIEKP KLLRRPILVD NKKLVIGYNP GELLKLSKKK
     TVHQSA
//

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