(data stored in SCRATCH zone)

SWISSPROT: FUR_BACSU

ID   FUR_BACSU               Reviewed;         149 AA.
AC   P54574;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   11-DEC-2019, entry version 113.
DE   RecName: Full=Ferric uptake regulation protein;
DE            Short=Ferric uptake regulator;
GN   Name=fur; Synonyms=yqkL; OrderedLocusNames=BSU23520;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RX   PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA   Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA   Kobayashi Y.;
RT   "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT   Bacillus subtilis genome containing the skin element and many sporulation
RT   genes.";
RL   Microbiology 142:3103-3111(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   SEQUENCE REVISION TO 103 AND 111.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   CHARACTERIZATION.
RX   PubMed=9701813; DOI=10.1046/j.1365-2958.1998.00921.x;
RA   Bsat N., Herbig A., Casillas-Martinez L., Setlow P., Helmann J.D.;
RT   "Bacillus subtilis contains multiple Fur homologues: identification of the
RT   iron uptake (Fur) and peroxide regulon (PerR) repressors.";
RL   Mol. Microbiol. 29:189-198(1998).
CC   -!- FUNCTION: Iron uptake repressor. Acts on the transcription of ferri-
CC       siderophore uptake genes.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Fur family. {ECO:0000305}.
DR   EMBL; D84432; BAA12648.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14284.2; -; Genomic_DNA.
DR   PIR; E69967; E69967.
DR   RefSeq; NP_390233.2; NC_000964.3.
DR   RefSeq; WP_003223972.1; NZ_JNCM01000036.1.
DR   SMR; P54574; -.
DR   STRING; 224308.BSU23520; -.
DR   PaxDb; P54574; -.
DR   PRIDE; P54574; -.
DR   EnsemblBacteria; CAB14284; CAB14284; BSU23520.
DR   GeneID; 938727; -.
DR   KEGG; bsu:BSU23520; -.
DR   PATRIC; fig|224308.179.peg.2564; -.
DR   eggNOG; ENOG4105I3K; Bacteria.
DR   eggNOG; COG0735; LUCA.
DR   HOGENOM; HOG000014143; -.
DR   InParanoid; P54574; -.
DR   KO; K03711; -.
DR   OMA; CDPRIQS; -.
DR   PhylomeDB; P54574; -.
DR   BioCyc; BSUB:BSU23520-MONOMER; -.
DR   PRO; PR:P54574; -.
DR   Proteomes; UP000001570; Chromosome.
DR   CollecTF; EXPREG_00000b40; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0032993; C:protein-DNA complex; IDA:CollecTF.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0001217; F:DNA-binding transcription repressor activity; IDA:CollecTF.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:CollecTF.
DR   GO; GO:0044212; F:transcription regulatory region DNA binding; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:CollecTF.
DR   GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:CollecTF.
DR   GO; GO:1900376; P:regulation of secondary metabolite biosynthetic process; IBA:GO_Central.
DR   CDD; cd07153; Fur_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR002481; FUR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR33202; PTHR33202; 1.
DR   Pfam; PF01475; FUR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P54574.
DR   SWISS-2DPAGE; P54574.
KW   Cytoplasm; DNA-binding; Iron; Metal-binding; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..149
FT                   /note="Ferric uptake regulation protein"
FT                   /id="PRO_0000095589"
FT   REGION          6..91
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          92..147
FT                   /note="Dimerization"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        93..97
FT                   /note="His-rich"
FT   METAL           37
FT                   /note="Zinc"
FT                   /evidence="ECO:0000250"
FT   METAL           85
FT                   /note="Zinc"
FT                   /evidence="ECO:0000250"
FT   METAL           93
FT                   /note="Iron"
FT                   /evidence="ECO:0000250"
FT   METAL           95
FT                   /note="Iron"
FT                   /evidence="ECO:0000250"
FT   METAL           97
FT                   /note="Zinc"
FT                   /evidence="ECO:0000250"
FT   METAL           108
FT                   /note="Zinc"
FT                   /evidence="ECO:0000250"
FT   METAL           115
FT                   /note="Iron"
FT                   /evidence="ECO:0000250"
FT   METAL           132
FT                   /note="Iron"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        103
FT                   /note="C -> F (in Ref. 1; BAA12648)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        111
FT                   /note="E -> G (in Ref. 1; BAA12648)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   149 AA;  17428 MW;  F6ACD6F0F397744D CRC64;
     MENRIDRIKK QLHSSSYKLT PQREATVRVL LENEEDHLSA EDVYLLVKEK SPEIGLATVY
     RTLELLTELK VVDKINFGDG VSRYDLRKEG AAHFHHHLVC MECGAVDEIE EDLLEDVEEI
     IERDWKFKIK DHRLTFHGIC HRCNGKETE
//

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